[WS(P)03] In vivo model and new cancer immunotherapy

[WS03-07-P] Robust pancreatic tumor suppression by a novel combination treatment with anti-PD-1 immune checkpoint antibody and stroma modifying RNA oligonucleotide STNM01 in mice

^○Juanjuan Ye^1,2, Futoshi Suizu¹, Keiko Yamakawa¹, Yuri Mukai¹, Akira Nishiyama², Hiroyuki Yoneyama³, Takayoshi Tsuchiya⁴, Motohiko Kato⁵, Naohisa Yahagi⁶, Kyuichi Kadota¹ (1.Molecular Oncologic Pathology, Department of Pathology and Host-Defense, Faculty of Medicine, Kagawa University, 2.Pharmacology, Department of Morphological and Functional Medicine, Faculty of Medicine, Kagawa University, Kita-gun, Kagawa, Japan., 3.TME Therapeutics Inc. Minato-ku, Tokyo, Japan., 4.Tokyo Medical University, Shinjuku-ku, Tokyo, Japan., 5.Center for Diagnostic and Therapeutic Endoscopy, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan., 6.Divison of Research and Development for Minimally Invasive Treatment, Cancer Center, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan.)

キーワード：

pancreatic ductal adenocarcinoma、carbohydrate sulfotransferase 15、oligonucleotide、tumor-draining lymph node、myeloid-derived suppressor cells

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