セッション詳細
[WS(O)03]In vivo model and new cancer immunotherapy
2024年12月3日(火) 14:00 〜 15:15
Room C
Organizers: Yuki Kagoya (Keio University), Keiko Udaka (Kochi University)
[WS03-01-O/P]LAG-3 blockade reactivates the CD8+ T cell expansion program to re-expand contracted clones in the tumor
○Munetomo Takahashi1, Mikiya Tsunoda2, Shigeyuki Shichino2, Shumpei Ishikawa1, Kouji Matsushima2, Satoshi Ueha2 (1.Department of Molecular Preventive Medicine, Graduate School of Medicine, The University of Tokyo, 2.Division of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute for Biomedical Sciences, Tokyo University of Science)
[WS03-06-O/P]PQDN improves CD8+ T cell metabolism by mitochondrial tuning resulting in improved cancer immunotherapy
○Huimin Sun1, Yosuke Dotsu1, Daisuke Muraoka1,2, Daisuke Kato4, Naohisa Ogo3, Yudai Sonoda3, Situo Deng1, Kiyoshi Yasui1, Mitsuhiro Yoneda1, Hiromu Kondo4, Akira Asai3, Hiroaki Ikeda1 (1.Department of Oncology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan, 2.Division of Translational Oncoimmunology, Aichi Cancer Research Institute, Nagoya, Japan, 3.Center for Drug Discovery, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan, 4.Department of Pharmaceutical Engineering and Drug Delivery Science, School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka, Japan)
[WS03-08-O/P]Cystatin A enhances CD4+ T cells and M1 macrophages antitumor activity in murine models of pancreatic cancer
○Alessandro Nasti1, Shingo Inagaki2, Tuyen Thuy Bich Ho1, Akihiro Seki3, Keiko Yoshida2, Kosuke Satomura2, Taro Yamashita2,3, Yoshio Sakai2, Shuichi Kaneko1,2,3 (1.Information-Based Medicine Development, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Japan., 2.System biology, Graduate School of Advanced Preventive Medical Sciences, Kanazawa University, Kanazawa, Japan., 3.Department of Gastroenterology, Kanazawa University Hospital, Kanazawa, Japan.)
[WS03-10-O/P]Synergistic Effects of Immune Checkpoint Inhibition Therapy with Lactobacillus Metabolites
○Takumi Iwasawa1,2,3, Suguru Yamauchi4, Tomoaki Ito3,5, Kazunori Kato1,2 (1.Inst. of Life Innova. Stu., Toyo Univ., 2.Grad. Sch Heal. & Sports Sci., Toyo Univ., 3.Shizuoka Med. Res. Center for Disast., Juntendo Univ., 4.Dept. Surg., Johns Hopkins Univ., 5.Dept. Surg., Shizuoka Hospital, Juntendo Univ.)
[WS03-11-O/P]Complete humanization of MHC region in mouse
○Teruhiko Suzuki1, Mana Yamakawa1, Saki An1, Hiroko Yanagisawa1, Yasuhiro Kazuki2,3,4,5, Mitsuo Oshimura2, Eiji Mizutani6, Takahiko Hara1,7,8 (1.Stem Cell Proj., Tokyo Metropol. Inst. Med. Sci., 2.CERC, Tottori Univ., 3.Div. of Chr. Biomed. Eng., Grad. Sch. of Med. Sci., Tottori Univ., 4.Chr. Eng. Group, ExCELLS., 5.Sch. of Life Sci., Facul. of Med., Tottori Univ., 6.Institute of Medicine, University of Tsukuba, 7.Grad. Sch., Tokyo Med. Dent. Univ., 8.Grad. Sch., Tokyo Metropol. Univ.)
[WS03-13-O/P]Anti-tumor effect of a human SIRPα antibody targeting human macrophages in a humanized mouse model
○Tania Afroj1, Satomi Komori1, Ikumi Katano2, Takeshi Takahashi2, Takenori Kotani1, Yoji Murata1, Takashi Matozaki1, Yasuyuki Saito1 (1.Kobe University Graduate School of Medicine, 2.Central Institute for Experimental Animals, Kawasaki, Japan)