セッション詳細
[WS(O)06]Arthritis and Fibrosis
2024年12月3日(火) 14:00 〜 15:15
Room F
Organizers: Kimito Kawahata (St. Marianna University School of Medicine), Haruka Tsuchiya (the University of Tokyo)
[WS06-01-O/P]Distinct proliferative and spatial properties of peripheral helper T cells in rheumatoid arthritis synovium
○Yuki Masuo1, Akinori Murakami1,2, Rinko Akamine1, Osamu Iri1, Koichi Murata2,3, Takayuki Fujii2,3, Yasuhiro Murakawa4,5, Chikashi Terao6, Yukinori Okada7,8,9, Motomu Hashimoto10, Hideki Ueno1,5, Hiroyuki Yoshitomi1,5 (1.Department of Immunology, Graduate School of Medicine, Kyoto University, 2.Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, 3.Advanced Medicine for Rheumatic Disease, Graduate School of Medicine, Kyoto University, 4.RIKEN-IFOM Joint Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, 5.Institute for the Advanced Study of Human Biology, Kyoto University, 6.Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, 7.Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, 8.Department of Statistical Genetics, Graduate School of Medicine, Osaka University, 9.Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, 10.Department of Clinical Immunology, Graduate School of Medicine, Osaka Metropolitan University)
[WS06-02-O/P]Human synovial Tph cells are involved in synovial inflammation in rheumatoid arthritis via a novel inflammatory humoral factor
○Akinori Murakami1,2,3, Rinko Akamine2,3, Yuki Masuo2,3, Osamu Iri2, Yasuhiro Murakawa4,5, Chikashi Terao6, Yukinori Okada7,8,9, Motomu Hashimoto10, Shuichi Matsuda1, Hideki Ueno2,3,5, Hiroyuki Yoshitomi2,3,5 (1.Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Japan, 2.Department of Immunology, Graduate School of Medicine, Kyoto University, Japan, 3.Kyoto University Immunomonitoring Center, Kyoto University, Japan, 4.RIKEN-IFOM Joint Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, 5.Institute for the Advanced Study of Human Biology, Kyoto University, Japan, 6.Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, 7.Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, Japan, 8.Department of Statistical Genetics, Graduate School of Medicine, Osaka University, Japan, 9.Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Japan, 10.Department of Clinical Immunology, Graduate School of Medicine, Osaka Metropolitan University, Japan)
[WS06-03-O/P]Expression of CD103 and CD200 define functionally distinct arthritogenic Th17 cells
○Yusuke Takeuchi1,2, Daiya Ohara1, Hitomi Watanabe1, Gen Kondoh1, Akio Morinobu2, Keiji Hirota1 (1.Laboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, 2.Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University)
[WS06-04-O/P]GM-CSF-dependent Macrophage Subpopulation Derived from Ly6Chi Monocytes Causes Development and Enhancement of Joint Inflammation in Autoimmune Arthritis
○Hiroki Mukoyama1,2, Yusuke Takeuchi1,2, Daiya Ohara1, Yoonha Lee1, Hitomi Watanabe1, Gen Kondoh1, Akio Morinobu2, Keiji Hirota1 (1.Laboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan., 2.Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan)
[WS06-05-O/P]The critical involvement of RasGRP4 in synovial resident cells in inflammatory arthritis
○Rihan Da, Tetsuya Saito, Natsuka Umezawa, Hiroyuki Baba, Wen Shi Lee, Shinsuke Yasuda (Department of Rheumatology, Tokyo Medical and Dental University)
[WS06-06-O/P]Identification of the oncostatin M-driven macrophage-fibroblast interaction as a drug target in autoimmune arthritis
○Rui Ling1, Nam Cong Nhat Huynh1, Masatsugu Komagamine1, Tianshu Shi1, Masayuki Tsukasaki2, Noriko Komatsu1,3, Hiroshi Takayanagi1 (1.Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan., 2.Department of Osteoimmunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan., 3.Department of Immune Regulation, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.)
[WS06-15-O/P]Attenuated Lung Fibrosis in Myeloid-Specific Ezh2 Deficient Mice: Insights from a Systemic Sclerosis Model
○Sita Virakul1, Benjawan Saechue2, Rajit Chompoowong3, Patipark Kueanjinda8, Haruhiko Koseki4, Nattiya Hirankarn5, Wijit Banlunara6, Benchaphorn Limcharoen7, Tanapat Palaga1 (1.Department of Microbiology, Faculty of Science, Chulalongkorn University, Bangkok, Thailand, 2.Faculty of Veterinary Science, Mahasarakham University, Mahasarakham, Thailand, 3.Medical Microbiology, Interdisciplinary Program, Graduate School, Chulalongkorn University, Bangkok, Thailand, 4.Center for Integrative Medical Sciences, RIKEN, Japan, 5.Center of Excellence in Immunology and Immune mediated Disease, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, 6.Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand, 7.Department of Anatomy, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand, 8.Department of Pathology, University of Massachusetts Medical School, MA, USA)
[WS06-18-O/P]rW27 alleviates E. faecalis-promoted, CDAHFD-induced NASH disease in mice by attenuating liver fibrosis
○CHEN XIU JIE1,2,3 (1.Graduate School of Frontier Sciences The University of Tokyo, 2.Institute for Quantitative Biosciences, The University of Tokyo, 3.Laboratory of Immunology and Infection Control, The University of Tokyo)