セッション詳細

[WS(P)06]Arthritis and Fibrosis

2024年12月3日(火) 16:50 〜 17:35
Poster 6

[WS06-01-O/P]Distinct proliferative and spatial properties of peripheral helper T cells in rheumatoid arthritis synovium

Yuki Masuo1, Akinori Murakami1,2, Rinko Akamine1, Osamu Iri1, Koichi Murata2,3, Takayuki Fujii2,3, Yasuhiro Murakawa4,5, Chikashi Terao6, Yukinori Okada7,8,9, Motomu Hashimoto10, Hideki Ueno1,5, Hiroyuki Yoshitomi1,5 (1.Department of Immunology, Graduate School of Medicine, Kyoto University, 2.Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, 3.Advanced Medicine for Rheumatic Disease, Graduate School of Medicine, Kyoto University, 4.RIKEN-IFOM Joint Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, 5.Institute for the Advanced Study of Human Biology, Kyoto University, 6.Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, 7.Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, 8.Department of Statistical Genetics, Graduate School of Medicine, Osaka University, 9.Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, 10.Department of Clinical Immunology, Graduate School of Medicine, Osaka Metropolitan University)

[WS06-02-O/P]Human synovial Tph cells are involved in synovial inflammation in rheumatoid arthritis via a novel inflammatory humoral factor

Akinori Murakami1,2,3, Rinko Akamine2,3, Yuki Masuo2,3, Osamu Iri2, Yasuhiro Murakawa4,5, Chikashi Terao6, Yukinori Okada7,8,9, Motomu Hashimoto10, Shuichi Matsuda1, Hideki Ueno2,3,5, Hiroyuki Yoshitomi2,3,5 (1.Department of Orthopaedic Surgery, Graduate School of Medicine, Kyoto University, Japan, 2.Department of Immunology, Graduate School of Medicine, Kyoto University, Japan, 3.Kyoto University Immunomonitoring Center, Kyoto University, Japan, 4.RIKEN-IFOM Joint Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, 5.Institute for the Advanced Study of Human Biology, Kyoto University, Japan, 6.Laboratory for Statistical and Translational Genetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, 7.Department of Genome Informatics, Graduate School of Medicine, the University of Tokyo, Japan, 8.Department of Statistical Genetics, Graduate School of Medicine, Osaka University, Japan, 9.Laboratory for Systems Genetics, RIKEN Center for Integrative Medical Sciences, Japan, 10.Department of Clinical Immunology, Graduate School of Medicine, Osaka Metropolitan University, Japan)

[WS06-03-O/P]Expression of CD103 and CD200 define functionally distinct arthritogenic Th17 cells

Yusuke Takeuchi1,2, Daiya Ohara1, Hitomi Watanabe1, Gen Kondoh1, Akio Morinobu2, Keiji Hirota1 (1.Laboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, 2.Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University)

[WS06-04-O/P]GM-CSF-dependent Macrophage Subpopulation Derived from Ly6Chi Monocytes Causes Development and Enhancement of Joint Inflammation in Autoimmune Arthritis

Hiroki Mukoyama1,2, Yusuke Takeuchi1,2, Daiya Ohara1, Yoonha Lee1, Hitomi Watanabe1, Gen Kondoh1, Akio Morinobu2, Keiji Hirota1 (1.Laboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University, Kyoto, Japan., 2.Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University, Kyoto, Japan)

[WS06-05-O/P]The critical involvement of RasGRP4 in synovial resident cells in inflammatory arthritis

Rihan Da, Tetsuya Saito, Natsuka Umezawa, Hiroyuki Baba, Wen Shi Lee, Shinsuke Yasuda (Department of Rheumatology, Tokyo Medical and Dental University)

[WS06-06-O/P]Identification of the oncostatin M-driven macrophage-fibroblast interaction as a drug target in autoimmune arthritis

Rui Ling1, Nam Cong Nhat Huynh1, Masatsugu Komagamine1, Tianshu Shi1, Masayuki Tsukasaki2, Noriko Komatsu1,3, Hiroshi Takayanagi1 (1.Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan., 2.Department of Osteoimmunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo, Tokyo, Japan., 3.Department of Immune Regulation, Medical Research Institute, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.)

[WS06-07-P]Single-cell transcriptomic analysis of arthritis-associated osteoclastogenic macrophages (AtoMs) identifies hypoxia-responsive pathological tissue remodeling and bone destruction.

Tomoya Agemura1,2, Yasuhito Yahara1, Kentaro Fujii1, Masaru Ishii1 (1.Department of Immunology and Cell Biology, Graduate School of Medicine and Frontier Biosciences, Osaka University, 2.JSPS Research Fellowship for Young Scientists)

[WS06-08-P]Dysfunctional Macrophages Exacerbate Autoimmune Arthritis in SKG Mice

Ayae Tanaka1, Takayoshi Owada2, Anna Hasegawa1, Nobuhide Tsuruoka3, Toshibumi Taniguchi4, Hirokuni Hirata2, Kazuhiro Kurasawa1, Kei Ikeda1, Masafumi Arima1 (1.Department of Rheumatology, Dokkyo Medical University School of Medicine, 2.Department of Respiratory Medicine and Clinical Immunology, Dokkyo Medical University Saitama Medical Center, 3.Department of Reproductive Medicine, Graduate School of Medicine, Chiba University, 4.Department of Infectious Diseases, Chiba University Hospital)

[WS06-09-P]The MALAT1/TGF-β signaling pathway is dysregulated in rheumatoid arthritis patients.

Misagh Rajabinejad1,2, Hossein Asgarian-Omran2,3 (1.Student Research Committee, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran, 2.Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran, 3.Molecular and Cell-Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran)

[WS06-10-P]Parsing the point of action of anti-rheumatic drugs and the mechanism of treatment-resistant synovitis by synovial single-cell analysis

Risa Yoshihara1, Haruka Tsuchiya1, Yasunori Omata2, Kazuyoshi Ishigaki3, Takahiro Itamiya1,4, Hiroaki Harada1, Hirofumi Shoda1, Kazuhiko Yamamoto3, Sakae Tanaka2, Tomohisa Okamura4, Keishi Fujio1 (1.Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 2.Department of Orthopaedic Surgery, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, 3.Laboratory for Human Immunogenetics, RIKEN Center for Integrative Medical Sciences, 4.Department of Functional Genomics and Immunological Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan)

[WS06-11-P]Analysis of soluble TIM-4 in the serum of patients with collagen diseases

Hisaya Akiba1, Yoshiyuki Abe2, Yoko Tabe3, Naoto Tamura2, Sachiko Miyake1 (1.Department of Immunology, Faculty of Medicine and Graduate School of Medicine, Juntendo University, 2.Department of Internal Medicine and Rheumatology, Faculty of Medicine and Graduate School of Medicine, Juntendo University, 3.Department of Clinical Laboratory Medicine, Faculty of Medicine and Graduate School of Medicine, Juntendo University)

[WS06-12-P]Alteration of CD4+ T cells with aging in arthritis model mice

Shusuke Tanaka, Taihei Nishiyama, Ayako Ohyama, Airi Kondo, Hiromitsu Asashima, Haruka Miki, Yuya Kondo, Hiroto Tsuboi, Isao Matsumoto (Department of Rheumatology, Institute of Medicine, University of Tsukuba)

[WS06-13-P]Computer model of remote inflammation of rheumatoid arthritis

Satoshi Yamada1, Akihiko Yoshimura2, Kaoru Murakami3, Rie Hasebe4, Masaaki Murakami3,4,5 (1.Okayama University of Science, 2.Tokyo University of Science, 3.Hokkaido University, 4.National Institute for Physiological Sciences, 5.National institutes for quantum and radiological science and technology)

[WS06-14-P]Heterogeneity of the Pathogenesis of Spondyloarthritis: Plasmacytoid Dendritic Cells Orient Axial Lesions

Sotaro Nakajima1, Haruka Tsuchiya1, Risa Yoshihara1, Kazuyoshi Ishigaki1,2, Haruka Takahashi1, Tomohisa Okamura3, Kazuhiko Yamamoto4, Hiroko Kanda1,5, Hirofumi Shoda1, Tetsuya Tomita6, Keishi Fujio1 (1.Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., 2.Laboratory for Human Immunogenetics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., 3.Department of Functional Genomics and Immunological Diseases, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., 4.Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan., 5.Immune-Mediated Diseases Therapy Center, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan., 6.Graduate School of Health Sciences, Morinomiya University of Medical Sciences, Osaka, Japan.)

[WS06-15-O/P]Attenuated Lung Fibrosis in Myeloid-Specific Ezh2 Deficient Mice: Insights from a Systemic Sclerosis Model

Sita Virakul1, Benjawan Saechue2, Rajit Chompoowong3, Patipark Kueanjinda8, Haruhiko Koseki4, Nattiya Hirankarn5, Wijit Banlunara6, Benchaphorn Limcharoen7, Tanapat Palaga1 (1.Department of Microbiology, Faculty of Science, Chulalongkorn University, Bangkok, Thailand, 2.Faculty of Veterinary Science, Mahasarakham University, Mahasarakham, Thailand, 3.Medical Microbiology, Interdisciplinary Program, Graduate School, Chulalongkorn University, Bangkok, Thailand, 4.Center for Integrative Medical Sciences, RIKEN, Japan, 5.Center of Excellence in Immunology and Immune mediated Disease, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, 6.Department of Pathology, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand, 7.Department of Anatomy, Faculty of Veterinary Science, Chulalongkorn University, Bangkok, Thailand, 8.Department of Pathology, University of Massachusetts Medical School, MA, USA)

[WS06-16-P]Ear thickness-based evaluation of the disease severity in a murine model of systemic sclerosis

Fatemeh Mirkatouli, Ryoken Yamanaka, Norimasa Yamasaki, Sawako Ogata, Kento Miura, Osamu Kaminuma (Hiroshima university)

[WS06-17-P]TNFα-induced adipose-related protein (TIARP) suppresses the pathogenesis of bleomycin induced pulmonary fibrosis

Yuka Yoshiki1,2, Haruka Miki1, Reona Tanimura1, Ryota Sato1, Ayako Ohyama1, Saori Abe1, Ayako Kitada1, Hiromitsu Asashima1, Yuya Kondo1, Hiroto Tsuboi1, Isao Matsumoto1 (1.Department of Rheumatology, Faculty of Medicine, University of Tsukuba, 2.College of Medical Sciences, School of Medicine and Health Sciences, University of Tsukuba)

[WS06-18-O/P]rW27 alleviates E. faecalis-promoted, CDAHFD-induced NASH disease in mice by attenuating liver fibrosis

CHEN XIU JIE1,2,3 (1.Graduate School of Frontier Sciences The University of Tokyo, 2.Institute for Quantitative Biosciences, The University of Tokyo, 3.Laboratory of Immunology and Infection Control, The University of Tokyo)