セッション詳細

[WS(P)08]Infection immunity 1

2024年12月3日(火) 16:50 〜 17:35
Poster 8

[WS08-01-O/P]Regnase-4 protects mice against HSV-1 infection by reinforcing type I interferon production

Keiko Yasuda1,2, Junichi Aoki1, Kotaro Tanaka1, Daiya Ohara3, Keiji Hirota3, Osamu Takeuchi1 (1.Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, 2.Department of Immunology, Nagoya City University Graduate School of Medical Sciences, 3.Laboratory of Integrative Biological Science, Institute for Life and Medical Sciences, Kyoto University)

[WS08-02-O/P]Transcription factor FOXO1 critically regulates viral replication and inflammatory reaction during SARS-CoV-2 infection both in in vitro and in vivo models.

Ryutaro Furukawa1, Noriko Ouji-Sageshima1, Masahiro Kitabatake1, Atsushi Hara1, Shigeyuki Shichino2, Satoshi Ueha2, Kouji Matsushima2, Toshihiro Ito1 (1.Department of Immunology, Nara Medical University, 2.Division of Molecular Regulation of Inflammatory and Immune Diseases, Research Institute for Biomedical Sciences, Tokyo University of Science)

[WS08-03-O/P]Immune profiling of less reactogenic mRNA vaccine revealed the pathways associated with adverse reaction

Tomohiro Takano1, Keigo Kumagai2, Hitoshi Iuchi3, Aya Mizuike2,4, Tomoharu Mizukami2, Eita Sasaki1, Koji Kobiyama5, Ken Ishii5, Michiaki Hamada3, Masayoshi Fukasawa2, Takayuki Matsumura1, Yoshimasa Takahashi1 (1.Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases, 2.Department of Biochemistry and Cell Biology, National Institute of Infectious Diseases, 3.Faculty of Science and Engineering, Waseda University, 4.Center for Quality Management Systems, National Institute of Infectious Diseases, 5.The Institute of Medical Science, The University of Tokyo)

[WS08-04-P]The balance of inflammatory and non-inflammatory IgG subclasses at pre-vaccination correlates with the reactogenicity of COVID-19 booster vaccines

Mizuki Fujisawa1, Takayuki Matsumura1, Saya Moriyama1, Yu Adachi1, Ryutaro Kotaki1, Tomohiro Takano1, Masaharu Shinkai2, Yoshimasa Takahashi1 (1.Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases, 2.Tokyo Shinagawa Hospital)

[WS08-05-P]Diminished Neutralization activity against the XBB1.5 Strain Post 6-month COVID-19 mRNA Booster Vaccination: Automated Pseudovirus-Based Neutralization Assay for Large-scale serosurveillance

Chieko Makino Okamura1,2, Tianchen Zhao3,4, Yuta Tani3, Morihito Takita3,4, Chika Yamamoto3,4, Hiroki Yoshimura3,4, Harumichi ishigame1,5, Takaharu Ueno6, Kazu Okuma6, Masatoshi Wakui7, Masaharu Tsubokura3,4, Hidehiro Fukuyama1,2,8,9 (1.Division of Immunology, Near InfraRed Photo-ImmunoTherapy Research Institute, Kansai Medical University, 2.Infectious Diseases Research Unit, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan, 3.General Incorporated Association for Comprehensive Disaster Health Management Research Institute, Tokyo, Japan, 4.Department of Radiation Health Management, Fukushima Medical University School of Medicine, Fukushima, Japan, 5.Laboratory for Tissue Dynamics, RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa, Japan, 6.Department of Microbiology, Kansai Medical University, School of Medicine, Hirakata, Osaka, Japan, 7.Department of Laboratory Medicine, Keio University School of Medicine, Tokyo, Japan, 8.Cell Integrative Science Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Kanagawa, Japan, 9.INSERM EST, Strasbourg, France)

[WS08-06-P]Development of a single-chain variable antibody fragment against a conserved region of the SARS-CoV-2 spike protein

Tingyu Gao, Atsushi Irie, Takahisa Kouwaki, Hiroyuki Oshiumi (Dep Immunol, Grad Sch Med Sci, Kumamoto University)

[WS08-07-O/P]History of infection and vaccination affects the quality of T cell responses in humans

Dongyun Lu1, Celine Chua1, Xinxin Xue1, Naila Shinwari1, Ito Isao2, Takao Hashiguchi3, Ryutaro Kotaki4, Yoshimasa Takahashi4, Hideki Ueno1 (1.Department of Immunology, Graduate School of Medicine, Kyoto University, 2.Department of Respiratory Medicine, Kyoto University Hospital, 3.Institute for Frontier Life and Medical Sciences, Kyoto University, 4.Research Center for Drug and Vaccine Development, National Institute of Infectious Diseases)

[WS08-08-O/P]Differential potency of memory T cells and memory B cells in older adults following COVID-19 mRNA vaccination

Kohei Kometani1, Takaaki Yorimitsu1,2, Norihide Jo1,3, Yoko Hamazaki1,4,5 (1.Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University, 2.Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, 3.Alliance Laboratory for Advanced Medical Research, Graduate School of Medicine, Kyoto University, 4.Laboratory of Immunobiology, Graduate School of Medicine, Kyoto University, 5.Kyoto University Immunomonitoring Center (KIC))

[WS08-09-P]The mechanism for maintenance of memory CD8 T Cells after COVID-19 mRNA vaccination

Takuto Nogimori1, Mayu Kumamoto1,2, Yuji Masuta1, Tomoka Matsuura3, Satoko Ohfuji3, Tetsuo Kase3, Kyoko Kondo4, Yu Nakagama5, Yasutoshi Kido5, Victor Appay6, Wakaba Fukushima3, Takuya Yamamoto1,2,7 (1.Laboratory of Precision Immunology, Center for Intractable Diseases and ImmunoGenomics, National Institutes of Biomedical Innovation, Health, and Nutrition, Osaka 567-0085, Japan, 2.Laboratory of Aging and Immune Regulation, Graduate School of Pharmaceutical Sciences, Osaka University, Osaka 565-0871, Japan, 3.Department of Public Health, Graduate School of Medicine, Osaka Metropolitan University, Osaka, 545-8585, Japan, 4.Management Bureau, Osaka Metropolitan University Hospital, Osaka, 545-8585, Japan, 5.Department of Virology and Parasitology, Graduate School of Medicine, Osaka Metropolitan University, Osaka, 545-8585, Japan, 6.Université de Bordeaux, CNRS UMR 5164, INSERM ERL 1303, ImmunoConcEpT, 33000 Bordeaux, France, 7.Department of Virology and Immunology, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan)

[WS08-10-O/P]HLA-C-restricted nucleocapsid-specific CTLs show potent antiviral activity and long-lived memory phenotype

Chihiro Motozono1, Mako Toyoda1, Hiroshi Hamana2, Hiroyuki Kishi2, Takamasa Ueno1 (1.Kumamoto University, Joint Research Center for Human Retrovirus infection, 2.University of Toyama, Department of Immunology, Faculty of Medicine, Academic Assembly)

[WS08-11-P]Self-assembling peptide CK2 contributes to the induction of antigen-specific cytotoxic T lymphocyte as a carrier of adjuvant and antigen

Koubun Yasuda1, Miya Fujimoto2, Etsushi Kuroda1 (1.Department of Immunology, School of Medicine, Hyogo Medical University, 2.Menicon Co., Ltd)

[WS08-12-P]An mRNA vaccine encoding the SARS-CoV-2 Omicron XBB.1.5 receptor-binding domain protects mice from the JN.1 variant

Ryuta Uraki1,2,3, Maki Kiso3, Mutsumi Ito2, Seiya Yamayoshi1,2,3, Peter Halfmann4, Shilpi Jain5,6,7, Mehul S. Suthar5,6,7,8, Nao Jounai9, Kazuki Miyaji9, Fumihiko Takeshita9, Yoshihiro Kawaoka1,2,3,4 (1.National Center for Global Health and Medicine, 2.Division of Virology, Institute of Medical Science, The University of Tokyo, 3.The University of Tokyo Pandemic Preparedness, Infection and Advanced Research Center (The UTOPIA Center), 4.Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, 5.Department of Pediatrics, Emory University School of Medicine, 6.Emory Vaccine Center, 7.Emory National Primate Research Center, 8.Department of Microbiology and Immunology, Emory University, 9.Vaccine Research Laboratories, R&D Division, Daiichi Sankyo Co., Ltd.)

[WS08-13-P]Hyaluronic acid nanogel to develop a new safe vaccine

Yuko Nariai1, Toru Katsumata2, Takashi Nakai1,2, Tsuyoshi Shimoboji2, Takeshi Urano1 (1.Vaccine and Therapeutic Antibodies for Emerging Infectious Diseases,Shimane University, 2.Asahi Kasei Corporation, Life Innovation Business Division, Healthcare Materials Division, New Product Development Office)

[WS08-14-P]Full-length nanopore sequencing of circular RNA landscape in peripheral blood cells following sequential BNT162b2 mRNA vaccination

Yu-Chen Liu1,2 (1.Laboratory for Human Immunology (Single Cell Genomics), WPI Immunology Frontier Research Center, Osaka University, 2.Center for Infectious Disease Education and Research (CiDER), Osaka University, Osaka, Japan.)

[WS08-15-P]Correlation analysis between repertoire and gene expression in SARS CoV-2 antigen-specific immune cells

Kosuke Miyauchi, Akiko Sugimoto, Takashi Watanabe (RIKEN IMS)

[WS08-16-O/P]Predictive Biomarkers of COVID-19 Prognosis Identified in Bangladesh Patients and Validated in Japanese Cohorts

Kazuko Uno1, Abu Hasan2, Rummana Rahim2, Toshio Tanaka3, Mizanur Rahman2, Kazuyuki Yoshizaki4 (1.IFN & Host-defense Research Laboratory, Louis Pasteur Center for Medical Research, 2.Evercare Hospital Dhaka, 3.Kinki Central Hospital, 4.Department of Organic Fine Chemicals, Institute of Scientific and Industry Research, Osaka University)

[WS08-17-P]Multi-omics Analysis of Autoantibody-Mediated Suppression of Type I Interferon Signaling in Myeloid Cells in Severe COVID-19 Patients

Masahiro Kiuchi1, Chiaki Iwamura1,2, Kaori Tsuji1, Atsushi Sasaki1, Takahisa Hishiya1, Rui Hirasawa1, Kota Kokubo1, Atushi Onodera1, Motoko Kimura2,3, Shinichiro Motohashi4, Kiyoshi Hirahara1,2,5 (1.Department of Immunology, Graduate School of Medicine, Chiba University, 2.Synergy Institute for Futuristic Mucosal Vaccine Research and Development, Chiba University, 3.Department of Experimental Immunology, Graduate School of Medicine, Chiba University, 4.Department of Medical Immunology, Graduate School of Medicine, Chiba University, 5.AMED-CREST)

[WS08-18-O/P]T cell repertoire and transcriptome profiling of CD8+ T cells in the peripheral blood of dengue virus infection during acute, early, and late recovery phases

Eleonor F Avenido-Cervantes1,2, Akiko Baba1, Jiun-Yu Jian3, Archival M Cervantes2, Blanca R Jarilla-Nagataki2, Mario Antonio L Jiz II2, Arthur Dessi E Roman4, Yu-Chen James Liu5, Daisuke Okuzaki5, Shusaku Mizukami3, Katsuyuki Yui3, kenji Hirayama1 (1.School of Tropical medicine and Global Health and NEKKEN, Nagasaki University, 2.Immunology Department, Research Institute for Tropical Medicine, Philippines, 3.Department of Immune regulation, Institute of Tropical Medicine (NEKKEN), Nagasaki University, 4.Clinical Research Division, Research Institute for Tropical Medicine, Philippines, 5.Human Immunology (Single Cell Genomics), Immunology Frontier Research Center: IFReC, Osaka University)

[WS08-19-P]Kupffer cell-B cell interaction promotes host defense against gut bacterial infection in the liver

Risako Kanemitsu1, Yu Miyamoto2,3, Masaru Ishii1,2,3 (1.Department of Immunology and Cell Biology, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan, 2.Department of Immunology and Cell Biology, Graduate School of Medicine, Osaka University, Osaka, Japan, 3.WPI-Immunology Frontier Research Center, Osaka University, Osaka, Japan)

[WS08-20-P]Exploring Immune Maturation and Allergy Suppression Through Natural Environment Exposure

Ayumi Okuzumi1, Kazuyo Moro1,2,3 (1.Laboratory for Innate Immune Systems, Graduate School of Medicine, Osaka University, 2.Laboratory for Innate Immune Systems, RIKEN-IMS, 3.Laboratory for Innate Immune Systems, iFReC, Osaka University)

[WS08-21-P]Viral Infections Assosiated to Patients with Hematologic Malignancies (HMs) and Hematopoietic Cell Transplant (HCT) Recipents

Rosinta Hotmaida Pebrianti Purba1, Lintong Hottua Simbolon1, Helen Try Juniasti2,1 (1.Department of Socioeconomics and Health Research, The Pranala Institute, Indonesia, 2.Department of Public Health, Cendrawsih University, Indonesia)