講演情報
[IO-5]Ce-BNC induced metal charge transfer mimicking Bioenzyme activity for chronic wound healing
*XIAO MIN XIA1,2, Xue Li1,2, Jie Liu1,2 (1. The Affiliated Hospital of Qingdao University, 2. Qingdao University)
[Objective]
Few studies have focused on the application of cerium single atoms in enzyme catalysis. Here, we develop a Ce-BNC that can serve as an efficient single-atom biooxidase analog.
[Method]
To reveal its structure-function relationship, the structural evolution of the peroxidase activity, superoxide dismutase, and catalase activity of monatomic nanozyme Ce-BNC was systematically studied. Furthermore, density functional theory (DFT) calculations revealed the coordination unsaturated active cerium sites and catalytic mechanism of Ce-BNC
[Results and Discussion]
We confirmed that the high catalytic activity of Ce-BNC is attributed to the active sites of coordinated unsaturated Ce-N4. In addition, the possible catalytic mechanism was revealed by DFT calculation.
[References]
1) Kraushofer F, Parkinson GS.Chem Rev 2022;122(18):14911-14939. doi:10.1021/acs.chemrev.2c00259
2) Mock SA, Sharp SE, Stoner TR,J Colloid Interface Sci 2016;466:261-267. doi:10.1016/j.jcis.2015.12.026
3) Huang H, Geng W, Wu X, et al. Angew Chem Int Ed Engl 2024;63(1):e202310811. doi:10.1002/anie.202310811
Fig.1 Surface analysis of Ce-BNC.
Fig.2 The antibacterial ability of the Ce-BNC.
Few studies have focused on the application of cerium single atoms in enzyme catalysis. Here, we develop a Ce-BNC that can serve as an efficient single-atom biooxidase analog.
[Method]
To reveal its structure-function relationship, the structural evolution of the peroxidase activity, superoxide dismutase, and catalase activity of monatomic nanozyme Ce-BNC was systematically studied. Furthermore, density functional theory (DFT) calculations revealed the coordination unsaturated active cerium sites and catalytic mechanism of Ce-BNC
[Results and Discussion]
We confirmed that the high catalytic activity of Ce-BNC is attributed to the active sites of coordinated unsaturated Ce-N4. In addition, the possible catalytic mechanism was revealed by DFT calculation.
[References]
1) Kraushofer F, Parkinson GS.Chem Rev 2022;122(18):14911-14939. doi:10.1021/acs.chemrev.2c00259
2) Mock SA, Sharp SE, Stoner TR,J Colloid Interface Sci 2016;466:261-267. doi:10.1016/j.jcis.2015.12.026
3) Huang H, Geng W, Wu X, et al. Angew Chem Int Ed Engl 2024;63(1):e202310811. doi:10.1002/anie.202310811
Fig.1 Surface analysis of Ce-BNC.
Fig.2 The antibacterial ability of the Ce-BNC.
