講演情報
[16p-B4-2][JSAP-Optica Joint Symposia Invited Talk] Controlling lyotropic liquid crystalline self-assembly for creating nano carriers for biomedical applications
〇Nhiem Tran1 (1.RMIT University)
キーワード：
nanoparticles、lipid、drug delivery
Lipid nanoparticles (LNP) have been widely used as carriers for drugs and genes, including in mRNA-vaccines for COVD-19. A special class of LNP, lyotropic liquid crystalline LNP, comprise mainly of amphiphilic lipids self-assembling into two- and three-dimensional, inverse hexagonal, and cubic nanostructures. Mesophase structures of self-assembled lyotropic liquid crystalline nanoparticles are important factors that directly influence their ability to encapsulate and release drugs and their biological activities.1, 2 For example, the release rate of hydrophilic compounds was found to be much faster in the cubic phase than in the hexagonal phase, micellar cubic phase, and microemulsion.3 Additionally, it has been shown that the internal nanostructures also affect cellular response such as cell uptake of nanoparticles, hemolysis, and cytotoxicity.4 Importantly, the in vivo behavior of nanoparticles such as biodistribution appears to be regulated by their nanostructures.5 However, it is difficult to predict and precisely control the mesophase behavior of these self-assembled nanomaterials, especially in complex systems with several components.
In this presentation, a structural study of self-assembled lipid mesophase using synchrotron small angle X-ray scattering will be reported. Using the understanding of the lipid self-assembled structures, lipid nanoparticles with different internal nanostructures will be created to study their in vitro interaction with cells and in vivobiodistribution. Furthermore, formulation of “smart” LNP, which switch between structures in response to pH will be reported. Since low pH conditions are observed in tumours and infected sites, an elevated release rate allows for better targeted therapies. Herein, pH responsive LNP containing novel ionisable lipids and their applications as carriers for anticancer and antimicrobial agents are reported.
In this presentation, a structural study of self-assembled lipid mesophase using synchrotron small angle X-ray scattering will be reported. Using the understanding of the lipid self-assembled structures, lipid nanoparticles with different internal nanostructures will be created to study their in vitro interaction with cells and in vivobiodistribution. Furthermore, formulation of “smart” LNP, which switch between structures in response to pH will be reported. Since low pH conditions are observed in tumours and infected sites, an elevated release rate allows for better targeted therapies. Herein, pH responsive LNP containing novel ionisable lipids and their applications as carriers for anticancer and antimicrobial agents are reported.
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