講演情報
[8p-A22-4]Photophysical characterization of methyl-bipyridyl corrole
〇(M1)Isabelle Cabral1, Pablo Goncalves1, Jaqueline Desordi1, Bernardo Iglesias2 (1.Fed. Univ. of Goias, 2.Fed. Univ. of Santa Catarina)
キーワード：
Photodynamic Therapy、Photophysical properties、Corrole
This study investigates the photophysical behavior of 10-(4-methyl-bipyridyl)-5,15-(pentafluorophenyl)corrole to assess its suitability as a photosensitizer for photodynamic therapy (PDT). The work also provides a theoretical overview of the photophysical mechanisms underlying PDT and of the main spectroscopic methods used to characterize photosensitizing compounds. The corrole was analyzed in toluene by UV-Vis absorption spectroscopy to identify its absorption bands, fluorescence spectroscopy to determine the fluorescence quantum yield, transient absorption spectroscopy (flash photolysis) to examine the kinetics of the triplet state, and near-infrared oxygen phosphorescence measurements. Tetraphenylporphyrin (TPP) was employed as the reference compound in all comparative analyses. The obtained absorption and emission profiles were
consistent with those typically observed for tetrapyrrolic macrocycles. The fluorescence quantum yield (f = 0.14) was approximately 40% higher than that of TPP. In addition, the triplet-state formation quantum yield (T = 0.48) and the singlet oxygen generation quantum yield
(Δ = 0.40) indicated favorable characteristics for use in PDT. Overall, the investigated corrole exhibited a combination of photophysical properties compatible with photodynamic applications, supporting further studies in biological environments and future {in vitro} cytotoxicity evaluations.
consistent with those typically observed for tetrapyrrolic macrocycles. The fluorescence quantum yield (f = 0.14) was approximately 40% higher than that of TPP. In addition, the triplet-state formation quantum yield (T = 0.48) and the singlet oxygen generation quantum yield
(Δ = 0.40) indicated favorable characteristics for use in PDT. Overall, the investigated corrole exhibited a combination of photophysical properties compatible with photodynamic applications, supporting further studies in biological environments and future {in vitro} cytotoxicity evaluations.