講演情報
[IL4]Native-State Structural Biology of the Vulnerable Brain
Yi-Wei Chang
(Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania)
◆略歴
Dr. Yi-Wei Chang is an Associate Professor of Biochemistry and Biophysics and Associate Director of the Institute of Structural Biology at the University of Pennsylvania. His laboratory specializes the use of cryo-electron tomography (cryo-ET) to visualize macromolecular machines directly inside cells at molecular resolution. By capturing biological structures in their native cellular environment, his work reveals how complex assemblies drive fundamental processes such as neurodegenerative diseases and host-pathogen interactions.
Dr. Chang’s research has uncovered key molecular machines that power secretion and invasion in apicomplexan parasites, providing structural insight into diseases such as malaria, toxoplasmosis, and cryptosporidiosis. His group also develops new technological and computational advances that expand cryo-ET into increasingly complex systems, including human brain tissue. Through integrative cellular structural biology, his lab bridges fundamental mechanism and translational opportunity, uncovering structural principles that inform the next generation of therapeutic strategies.
(Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania)
◆略歴
Dr. Yi-Wei Chang is an Associate Professor of Biochemistry and Biophysics and Associate Director of the Institute of Structural Biology at the University of Pennsylvania. His laboratory specializes the use of cryo-electron tomography (cryo-ET) to visualize macromolecular machines directly inside cells at molecular resolution. By capturing biological structures in their native cellular environment, his work reveals how complex assemblies drive fundamental processes such as neurodegenerative diseases and host-pathogen interactions.
Dr. Chang’s research has uncovered key molecular machines that power secretion and invasion in apicomplexan parasites, providing structural insight into diseases such as malaria, toxoplasmosis, and cryptosporidiosis. His group also develops new technological and computational advances that expand cryo-ET into increasingly complex systems, including human brain tissue. Through integrative cellular structural biology, his lab bridges fundamental mechanism and translational opportunity, uncovering structural principles that inform the next generation of therapeutic strategies.
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