講演情報
[II-OR19-02]Effects of Home-Based Exercise Rehabilitation Training on Cardiopulmonary Function in Children with PAH: A Prospective Pilot Study
○Dan Wang, Yunbin Xiao, Lin Chen, Zhou Yang (Department of Cardiology, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan children's hospital))
キーワード：
Pulmonary arterial hypertension、home-based exercise rehabilitation、Targeted drug therapy
Objective: to evaluate the efficacy of a home-based exercise rehabilitation program combined with targeted drug therapy on improving cardiopulmonary function in clinically stable pediatric PAH patients.Methods: Pediatric patients with PAH receiving targeted drug therapy were prospectively enrolled in this self-controlled study. A home-based walking-centric exercise regimen was implemented, with exercise intensity at 60% of the predicted maximum heart rate and SpO maintained at>90%. Exercise parameters were monitored using wearable devices. Assessments included blood biochemistry, echocardiography, WHO functional class, a 6MWT, CPET, and QoL evaluation, conducted at baseline and after three months. Results: Twenty patients ( mean age 8.67±3.89 years) were enrolled, including 14 with idiopathic PAH and 6 with post-operative PAH. Following rehabilitation, significant improvements were noted: 6MWT distance increased from 369.75±3107.41 m to 425.75±385.33 m (P = 0.012), and NT-proBNP decreased from a median of 163.5 to 98.5 ng/L (P = 0.017). Echocardiography showed reduced PASP (88.88±316.71 to 67.25 ±318.96 mmHg, P = 0.017) and enhanced RV function (increased fractional area change and TAPSE). QoL scores improved by 21.5% (P = 0.028). VOpeak (18.4 to 21.9 mL/kg/min, P = 0.015). No adverse events occurred.Conclusion: Targeted drug therapy combined with home-based exercise rehabilitation significantly enhances RV functional reserve, exercise capacity, and QoL in pediatric PAH patients. Further studies are required to validate long-term benefits.