講演情報
[II-OR22-01]Stereotactic Body Radiotherapy: A New Noninvasive Way to Conduct Pulmonary Artery Denervation?
○Yunbin Xiao, Manzhen Liao, Taoyue Yao, Yonghui Xie (Department of Cardiology, The Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan children's hospital))
キーワード：
Pulmonary arterial hypertension、Stereotactic body radiotherapy、Pulmonary artery denervation
OBJECTIVES to investigate the feasibility of stereotactic body radiotherapy (SBRT) for performing pulmonary artery denervation (PADN).METHODS A total of 12 healthy male New Zealand rabbits were digitally marked on their foreheads and randomly divided into control group (n = 6) and SBRT group (n = 6) at a ratio of 1:1 using Computer-generated random numbers. In SBRT group, rabbits were treated with a single dose of 15 Gray (Gy), then bred for a minimum of 3 months. The rabbit models of acute thromboembolic pulmonary arterial hypertension (ATEPAH) were established by injecting autologous blood clots into the femoral vein (FV). Right ventricular (RV) function and hemodynamics were assessed by echocardiography and right heart catheterization (RHC). Pulmonary artery (PA) sympathetic nerves (SNs) were evaluated by pathological staining.RESULTS The SBRT procedure was successfully performed in all six rabbits. Compared to control group, SBRT-PADN reduced pulmonary artery systolic pressure (PASP) and mean pulmonary artery pressure (mPAP) in ATEPAH rabbits. Meanwhile, SBRT-PADN could attenuate PA dilatation in ATEPAH rabbits. Histological examination revealed evident structural damages in SNs of SBRT-PADN animals, including vacuolization, nuclear pyknosis and digestion chambers. No adverse events had been observed, with sparing of PA of the intima and media were detected up to 90 days post procedure.CONCLUSIONS SBRT could destroy SNs around PA locally, which may represent a novel option for performing PADN. Besides, this study proveded its short-term effectiveness and safety.