講演情報
[III-P03-2-01]Case Series of Probiotic Sepsis Associated with Probiotic Use in Children Following Cardiac Surgery
○Xiaofeng Wang, Xu Wang, Shilin Wang, Zhiyuan Zhu (Department of PICU, FuWai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China)
キーワード：
Probiotic Sepsis、Probiotic Use、Cardiac Surgery
Background: This study aims to investigate the probiotic sepsis in children following cardiac surgery.Methods: This study was conducted retrospectively at our single center. We included patients from 2019 to 2024. Results: Among all 57 positive blood cultures, 6 cases were probiotics. Case 1, aged 6 years, underwent TCPC and tested positive for Bacillus licheniformis without probiotics use. She was treated with imipenem + vancomycin and had no infection-related complications. Case 2, aged 8 months, underwent PA banding and tested positive for Bacillus subtilis with probiotics use. He was treated with linezolid + cefoperazone/sulbactam and had complications of embolic stroke. Case 3, aged 8 months, underwent RV-PA connection surgery and tested positive for Bacillus subtilis without probiotics use. He was treated with meropenem and had no complications. Case 4, aged 1.5 years, underwent DSO and tested positive for Bacillus subtilis with probiotics use. He was treated with meropenem + vancomycin and had no complications. Case 5, aged 9 months, underwent PA banding and tested positive (blood + central venous catheter) for Bacillus subtilis without probiotics use. She was treated with piperacillin/tazobactam and had no complications. Case 6, aged 13 years, underwent tricuspid valve replacement and tested positive for Lactobacillus rhamnosus with probiotics use. She was treated with meropenem and died of septic.Conclusions: Probiotic sepsis is not uncommon in children after cardiac surgery. The use of probiotics cannot be considered risk-free.