講演情報
[III-TLR-3]Lipid Metabolism Dynamics in Postnatal Heart Regeneration and Stress Response
○Wataru Kimura (Shinshu University)
キーワード：
regeneration、cell cycle、lipid metabolism
Objective: Adult mammals lack the ability to regenerate injured myocardium, making ischemic heart disease a leading cause of death worldwide. In contrast, fetal and early neonatal mammals retain cardiac regeneration capacity only for a short period after birth. To enable cardiomyocyte cell cycle re-entry and promote regeneration in the adult heart, we aim to elucidate the molecular mechanisms underlying the metabolic shifts in the postnatal heart. Methods: We conducted cross-species multi-omics analysis to identify regulatory pathways governing postnatal metabolic transitions in mammalian hearts. We then tested candidate factors using genetic and pharmacological interventions, primarily in mice. Results: We identified AMPK signaling and nucleotide metabolism as key pathways driving postnatal cardiomyocyte cell cycle arrest. In addition, we show that shifts in lipid metabolism are associated with regenerative and stress response capacities in the postnatal heart. Conclusion: Our findings advance understanding of metabolic maturation in mammalian cardiomyocytes and provide a foundation for future studies to define molecular links between metabolic remodeling and regenerative competence in the postnatal heart.
