講演情報
[III-TLR-7]Fusion of Real and Virtual: A Novel Supporting System for Congenital Heart Disease Surgery using 3D Replicas and Computer Simulations
○Isao Shiraishi1,2, Kenichi Kurosaki1,2, Shigemitsu Iwai1,2, Takaya Hoashi2, Kisaburo Sakamoto2, Shinichiro Oda2, Shingo Kasahara2, Hiroyuki Yamagishi2, Takumi Washio2,3, Toshiaki Hisada2,3 (1.National Cerebral and Cardiovascular Center, 2.Research and Development Group of Japan Agency for Medical Research and Development (AMED), 3.The University of Tokyo Graduate School of Frontier Sciences)
キーワード：
simulation、digital twin、computational flow dynamics
A precise understanding of the three-dimensional (3D) anatomical structure is essential for the successful surgical treatment of complicated congenital heart disease (CHD). We have developed precise, highly flexible polyurethane replicas of CHD using stereolithography 3D printing followed by vacuum casting. As a result, the heart replicas have been approved as medical devices and are covered by Japan's national insurance scheme. The effectiveness of the support system was further enhanced by adding a functional analysis capability. Specifically, we developed a novel computer simulation system for pediatric CHD called 'ped-UT Heart', in which blood pressure, blood flow velocity, wall motion, valve motion, energy loss, oxygen concentration, and electrophysiology are simulated using a patient-specific finite element heart model. This enables different surgical procedures to be compared prior to surgery. We are now conducting a multicenter clinical trial to demonstrate its usefulness and efficacy. In summary, a fusion system combining physical and virtual simulation (super-flexible 3D heart replicas and ped UT-Heart, respectively) could be an ideal medical device for supporting surgery on intractable, complicated CHD. (This research and development was accomplished in collaboration with CrossMedical Co., Ltd., UT-Heart Inc., and Q'sfix Corp. The authors would like to thank Jinse Shimo for his computational analyses of the patients. We would also like to acknowledge the invaluable assistance of Professor Masaaki Yamagishi in developing the Super Flexible 3D Heart Models.)
