[Symposium 108] Recent Advances and Future Directions in Nuroimaging and Neurophysiological Studies in Schizophrenia

[SY-108-01] Current Findings and Perspectives on Neural Oscillation Deficits in Schizophrenia

*Yoji Hirano¹ (1. Department of Psychiatry, University of Miyazaki (Japan))

キーワード：

Neural Oscillation、Schizophrenia、EEG、multi-site study、translational research

In research on psychiatric disorders, where abnormalities in both lower- and higher-order brain functions are intricately intertwined, objective evaluation of brain function and the establishment of reproducible functional biomarkers that reflect such dysfunctions are indispensable. In this regard, electroencephalography (EEG) and magnetoencephalography (MEG), as physiological brain function tests, are particularly suitable for assessing the dynamic nature of brain activity. They also offer high reproducibility and are regaining attention due to advances in digitalization and innovative analytical techniques. Furthermore, in basic research, the advent of optogenetics has enabled the integration of clinical and preclinical findings on EEG, thereby facilitating bidirectional translational research. In this presentation, I will outline the utilization of EEG data as functional biomarkers in psychiatric disorders—particularly schizophrenia—and describe our ongoing multi-site collaborative study on EEG across different disorders. I will also discuss methods for database construction, its significance, as well as future challenges and perspectives.