セッション詳細

[P1]Poster Session Core Time (奇数番号)

2025年3月17日(月) 18:00 〜 19:00
国際会議室 301(3F)

[P1-1]Diverse Characteristics of Pulmonary Neuroendocrine Cells
in Airway Inflammation

*Masahiro Nemoto1, Masahiro Kiuchi1, Kaori Tsuji1, Tsuguko Tomita1, Kiyoshi Hirahara1 (1. Department of Immunology, Chiba University, Graduate School of Medicine (Japan))

[P1-3]Thioredoxin-interacting protein is essential for memory T cell formation via the regulation of the redox metabolism

*Kota Kokubo1, Kiyoshi Hirahara1, Masahiro Kiuchi1, Kaori Tsuji1, Yuri Sonobe1, Rie Shinmi1, Takahisa Hishiya1, Chiaki Iwamura1, Atsushi Onodera1, Toshinori Nakayama1 (1. Department of Immunology, Graduate School of Medicine, Chiba University (Japan))

[P1-5]プラズマ細胞の誘導部位におけるKLF2の発現が骨髄への遊走の運命を決定する
Plasma cell KLF2 expression at the induction site directs migration to the bone marrow

*Takuya Koike1,2,3,4, Wataru Ise3,4,5, Takeshi Inoue1,3, Tomohiro Kurosaki2,3,4 (1. UTOPIA , The University of Tokyo (Japan), 2. IMS, RIKEN (Japan), 3. IFReC, Osaka University (Japan), 4. CiDER, Osaka University (Japan), 5. CAMaD, Osaka University (Japan))

[P1-7]Single-cell analysis reveals age-related differences in the T cell response to COVID-19 mRNA vaccines

*Ayana Sunami1,2, Norihide Jo2,3, Yoko Hamazaki1,2,4 (1. Laboratory of Immunobiology, Graduate School of Medicine, Kyoto University (Japan), 2. Department of Life Science Frontiers, Center for iPS Cell Research and Application (CiRA), Kyoto University (Japan), 3. Alliance Laboratory for Advanced Medical Research, Graduate School of Medicine, Kyoto University (Japan), 4. Kyoto University Immunomonitoring Center (KIC) (Japan))

[P1-9]肺胞マクロファージを介したレジデントメモリーCD8+T細胞の誘導
Induction of resident memory CD8+T cells by alveolar macrophages

*Takumi Kawasaki1, Moe Ikegawa1 (1. National Research Center for the Control and Preventation of Infectious Diseases Nagasaki University (Japan))

[P1-11]セマフォリン6Dは扁桃体の神経回路形成を介して情動、代謝、炎症応答を担う
Semaphorin 6D tunes amygdalar circuits for coordinate emotional, metabolic, and inflammatory outputs

*Mayuko Izumi1, Yoshimitsu Nakanishi1, Sujin Kang2, Atsushi Kumanogoh1 (1. Department of Respiratory Medicine and Clinical Immunology, Graduate School of medicine, Osaka University (Japan), 2. Laboratory of Immune Regulation, WPI-IFReC, Osaka University (Japan))

[P1-13]A study on human immune assessment methods focused on multi-omics approaches to genetic diversity and functionality

*Akari Suzuki1, Matteo Guerrini1, Anunya Opasawatchai1, Kazuhiko Yamamoto1 (1. Center for integrative medical science, RIKEN (Japan))

[P1-15]Single cell suppression profiling of human regulatory T cells

*David G Priest1, Jonas N Sondergaard2, James B Wing1,2 (1. Human Immunology (Single Cell Immunology) Laboratory, Immunology Frontier Research Center, The University of Osaka (Japan), 2. Human Single Cell Immunology Team, CIDER, Osaka University (Japan))

[P1-17]Development of a subunit booster vaccine enhancing protective effect of BCG vaccine

*Kazuhiro Matsuo1, Satoru Mizuno1, Hiroto Takeuchi1, Kensuke Takada1 (1. Institute for Vaccine Research and Development, Hokkaido University (Japan))

[P1-19]FBXO11 constitutes a major negative regulator of MHC class II

*Yusuke Kasuga1,3, Ryota Ouda1, Masashi Watanabe2, Xin Sun1, Riko Izawa1, Miki Kimura1, Atsuki Takeishi1,3, Tsutomu Tanaka1,3, Shigetsugu Hatakeyama2, Koichi Kobayashi1,3 (1. Department of Immunology, Faculty of Medicine, Hokkaido University (Japan), 2. Department of Medical Chemistry, Faculty of Medicine, Hokkaido University (Japan), 3. Hokkaido University Institute for Vaccine Research and Development (Japan))

[P1-21]Utilization of a Novel Mast Cell Line, “Cell-line of Serosa-Infiltrated Mast Cell for Versatile Analysis#1 (cSIMVA1),” for Vaccine Modality Validation

*Yuqing WU1,2, Haruki SASA1,2, NAREN TONGLEGA1,2, Zhongwei Zhang1,2, Mariko KITAJIMA3, Hayato ISHIKAWA3, Hiroshi KIYONO1,2,4, Yosuke KURASHIMA1,2,4 (1. Department of Innovative Medicine, Graduate School of Medicine, Institute for Advanced Academic Research/ Research Institute of Disaster Medicine, Chiba University, Chiba, Japan. (Japan), 2. Chiba University Synergy Institute for Futuristic Mucosal Vaccine Research and Development (cSIMVa), Department of Human Mucosal Vaccinology, Chiba University Hospital, Chiba, Japan. (Japan), 3. Laboratory of Middle Molecular Chemistry, Graduate School of Pharmaceutical Sciences, Chiba University (Japan), 4. Division of Comparative Pathology and Medicine, Chiba University-University of California San Diego Center for Mucosal Immunology, Allergy and Vaccine (cMAV), School of Medicine, San Diego, CA, USA. (United States of America))

[P1-23]MHC class II limits microbiota-dependent activation of colonic CD8 T cells in a CD4 T cell- and LAG-3-dependent manner

*Tomoya Sengiku1, Masato Kubo2,3, Shohei Hori1, Ruka Setoguhi1 (1. Graduate School of Pharmaceutical Sciences, The University of Tokyo (Japan), 2. Research Institute for Biomedical Science, Tokyo University of Science (Japan), 3. Research Center for Integrative Medical Science (IMS), RIKEN Yokohama Institute (Japan))

[P1-25]Confidential

*Akane Kurosugi1, Chiaki Iwamura1, Kiyoshi Hirahara1 (1. Department of Immunology, Graduate School of Medicine, Chiba University (Japan))

[P1-27]Confidential

*Burcu Temizoz1,2,3,4, Takayuki Shibahara5,2, Shiori Egashira2, Koji Hosomi6, Jonguk Park7, Naz Surucu13, Albin Bjork18,19, Erdal Sag14, Takehiko Doi15, Rabia Miray Kisla Ekinci17, Sibel Balci17, Marjan A. Versnel19, Jun Kunisawa6, Masahiro Yamamoto8, Kouji Kobiyama1,2,3,4, Peter D. Katsikis19, Cevayir Coban9,3,4, Mayda Gursel16, Seza Ozen14, Sumiyuki Nishida5, Atsushi Kumanogoh5,11,12,10, Ken J. Ishii1,2,3,4 (1. Division of Vaccine Science, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan (Japan), 2. Laboratory of Mockup Vaccine, Center for Vaccine and Adjuvant Research, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Osaka, Japan (Japan), 3. International Vaccine Design Center (VDesC), The Institute of Medical Science (IMSUT), The University of Tokyo, Tokyo, Japan (Japan), 4. The University of Tokyo Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA), The University of Tokyo, Tokyo, Japan (Japan), 5. Department of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan (Japan), 6. Laboratory of Vaccine Materials, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Osaka, Japan (Japan), 7. Laboratory of Bioinformatics, Artificial Intelligence Center for Health and Biomedical Research, National Institutes of Biomedical Innovation, Health and Nutrition, Ibaraki, Osaka, Japan (Japan), 8. Department of Immunoparasitology, Division of Infectious Disease, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan (Japan), 9. Division of Malaria Immunology, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan (Japan), 10. Department of Immunopathology, WPI, Immunology Frontier Research Center (IFReC), Osaka University, Suita, Osaka, Japan (Japan), 11. Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives (OTRI), Osaka University, Suita, Osaka, Japan (Japan), 12. Center for Infectious Diseases for Education and Research (CiDER), Osaka University, Suita, Osaka, Japan (Japan), 13. Department of Biological Sciences, Middle East Technical University (METU), Ankara, Turkey (Turkey), 14. Department of Pediatric Rheumatology, Hacettepe University, Ankara, Turkey (Turkey), 15. Department of Pediatrics, Graduate School of Biomedical and Health Science, Hiroshima University, Hiroshima, Japan (Japan), 16. Izmir Biomedicine and Genome Center, Izmir, Turkey (Turkey), 17. Department of Pediatric Rheumatology, Cukurova University, Adana, Turkey (Turkey), 18. Division of Rheumatology, Department of Medicine, Karolinska Institute, Karolinska University Hospital Solna, Stockholm, Sweden (Sweden), 19. Department of Immunology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands (Netherlands))

[P1-29]血中好中球から辿る、ウイルス感染個体の生死を分けるメカニズム
Profiling of neutrophils predicts the survival fate upon lethal viral infection

*Riho Saito1, Tomohiko Okazaki2, Hiroki Sugishita3, Yukiko Gotoh1 (1. Graduate school of pharmaceutical sciences, University of Tokyo (Japan), 2. Institute for Genetic Medicine, Hokkaido University (Japan), 3. International Research Center for Neurointelligence (IRCN), The University of Tokyo (Japan))

[P1-31]Tumor associated macrophage suppresses anti-tumor immunity by inducing Th1-Treg differentiation

*Ayumi Kuratani1, Masahiro Yamamoto1,2,3,4 (1. Department of Immunoparasitology, RIMD, Osaka University (Japan), 2. Laboratory of Immunoparasitology, IFReC, Osaka University (Japan), 3. CiDER, Osaka University (Japan), 4. CAMaD, Osaka University (Japan))

[P1-33]Distinct Immune Cell Alterations Induced by SARS-CoV-2 Vaccination and Infection

*Anunya Opasawatchai1, Masahiro Nakano2, Akari Suzuki1, Kazuyoshi Ishigaki2, Kazuhiko Yamamoto1 (1. Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences (Japan), 2. Laboratory for Human Immunogenetics,RIKEN Center for Integrative Medical Sciences (Japan))

[P1-35]Elucidating the molecular pathways of immune activation mediated by mRNA vaccine

*Taku Kureha1, Ryunosuke Muro2, Wang Suqi1, Takeshi Nitta2, Hiroshi Takayanagi1 (1. The University of Tokyo (Japan), 2. Tokyo University of Science (Japan))

[P1-37]Modulating reactogenicity and immunogenicity in mRNA-LNP vaccines through lipid component optimization

*Haruki Hirata1,2,3, Yoshino Kawaguchi2, Mari Kimura2,4, Hiroki Tanaka1,5, Toshiro Hirai1,2,3,6, Hidetaka Akita1,5, Taro Shimizu1,2,6, Yasuo Yoshioka1,2,3,4,6,7,8 (1. Center for Advanced Modalities and DDS, Osaka University (Japan), 2. Research Institute for Microbial Diseases, Osaka University (Japan), 3. Graduate School of Pharmaceutical Sciences, Osaka University (Japan), 4. The Research Foundation for Microbial Diseases of Osaka University (Japan), 5. Graduate School of Pharmaceutical Sciences, Tohoku University (Japan), 6. Institute for Open and Transdisciplinary Research Initiatives, Osaka University (Japan), 7. Center for Infectious Disease Education and Research, Osaka University (Japan), 8. Global Center for Medical Engineering and Informatics, Osaka University (Japan))

[P1-39]弱毒ワクシニアウイルスDIsのmpoxに対する有効性の解析
Efficacy of an attenuated vaccinia virus DIs against mpox in animal models

*Kenichi Otaki1, Fumihiro Yasui2, Hirohito Ishigaki1, Naoko Kitagawa1, Michinori Kohara2, Koji Ishii3, Yasushi Itoh1 (1. Division of Pathogenesis and Disease Regulation, Department of Pathology, Shiga University of Medical Science (Japan), 2. Department of Microbiology and Cell Biology, Tokyo Metropolitan Institute of Medical Science (Japan), 3. Department of Quality Assurance and Radiological Protection, National Institute of Infectious Diseases (Japan))

[P1-41]Confidential

*Yohei Uchida1, Rika Nakahashi1,2, Shingo Umemoto1,3, Hiroshi Kiyono1,2,4,5,6,7 (1. Department of Human Mucosal Vaccinology, Chiba University Hospital (Japan), 2. Synergy Institute for Futuristic Mucosal Vaccine Research and Development (cSIMVa), Chiba University (Japan), 3. Department of Otorhinolaryngology and Head & Neck Surgery, Faculty of Medicine, Oita University (Japan), 4. Future Medicine Education and Research Organization, Chiba University (Japan), 5. Department of Medicine, UC San Diego School of Medicine (United States of America), 6. CU-UCSD Center for Mucosal Immunology, Allergy and Vaccines (cMAV), UC San Diego School of Medicine (United States of America), 7. Division of Infectious Disease Vaccine R&D, Research Institute of Disaster Medicine, Chiba University (Japan))

[P1-43]AAV関連技術を活用した次世代ワクチンの開発
Development of nucleic acid vaccine with AAV empty capsids and exosomes

*Yuji Tsunekawa1, Ken Sugo1, Ysunari Matsuzaka1, Hiromi KInoh1, Hiroshi Ueki2, Seiya Yamayoshi2, Takashi Okada1 (1. Institute of Medical Science, The University of Tokyo DMMG (Japan), 2. Institute of Medical Science, The University of Tokyo DV (Japan))

[P1-45]Sublingual immunization with inactivated enterovirus A71 induced pathogen-specific mucosal and systemic protective antibody responses.

*Meito Shibuya1,2, Risa Takahashi1, Tomonori Machita1, Tomoyuki Yamanoue1, Satoshi Koike3, Kyousuke Kobayashi3, Seiya Yamayoshi5,4, Hiroshi Kiyono1,7, Kohtaro Fujihashi1,6,8,9 (1. Department of Human Mucosal Vaccinology, Chiba University Hospital, and Chiba University Synergy Institute for Futuristic Mucosal Vaccine Research and Development (cSIMVa), Chiba University, Chiba (Japan), 2. Vaccine R&D Laboratory, Vaccine Business Division, Shionogi & Co., Ltd., Osaka (Japan), 3. Neurovirology Project, Department of Diseases & Infection, Tokyo Metropolitan Institute of Medical Science, Tokyo (Japan), 4. Div. Virology and Intern. Res. Ctr Infect. Dis., Inst. Med. Sci., and Univ. Tokyo Pandemic Prep., Infect. Adv. Res. Ctr (UTOPIA), The University of Tokyo, Tokyo (Japan), 5. The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute, Tokyo (Japan), 6. Division of Infectious Disease Vaccine R&D, Research Institute of Disaster Medicine, Chiba University, Chiba (Japan), 7. Chiba University-University of California San Diego Center for Mucosal Immunology, Allergy and Vaccine (CU-UCSD cMAV), Department of Medicine, School of Medicine, San Diego, CA (United States of America), 8. Division of Mucosal Vaccines, International Vaccine Design Center, The Institute of Medical Science, The University of Tokyo, Tokyo (Japan), 9. Department of Pediatric Dentistry, The University of Alabama at Birmingham, Birmingham AL (United States of America))

[P1-47]Establishment of aerosol M. tuberculosis challenge system in mice for evaluation of protective immunity

*Satoru Mizuno1, Kensuke Takada1, Hiroto Takeuchi1, Kazuhiro Matsuo1 (1. Institute for Vaccine Research and Development, Hokkaido University (Japan))

[P1-49]How Does Stress Affect Vaccine Effectiveness?

*Ryuta Uraki1,2,3, Yoshihiro Kawaoka1,2,3,4 (1. UTOPIA, The University of Tokyo (Japan), 2. Division of Virology, Institute of Medical Science, The University of Tokyo (Japan), 3. The Research Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute (Japan), 4. Department of Pathobiological Sciences, School of Veterinary Medicine, University of Wisconsin-Madison (United States of America))

[P1-51]Confidential

*Hiromi Mori1 (1. Department of Human Mucosal Vaccinology, Chiba University Hospital (Japan))

[P1-53]Evaluation of Intradermal Injection System (Immucise) for the Live Attenuated Vaccine, centrin-deficient Leishmania major (LmCen-/-), against Leishmaniasis

*Farzaneh Valanezhad1,2,3, Jalal Alshaweesh4, Shara Bakytbek1,2,3, Sakiko Shimizu5, Ryo Tanaka5, Yoichiro Iwase5, Risa Nakamura1,2,3, Greg Matlashewski6, Sreenivas Gannavaram7, Hira Nakhasi7, Abhay Satoskar8, Shinjiro Hamano1,2,3 (1. Institute of Tropical Medicine, Nagasaki University (Japan), 2. Graduate School of Biomedical Sciences. Nagasaki University, Nagasaki (Japan), 3. The Vaccine Research and Development Center, DEJIMA Infectious Disease Research Alliance (DIDA), Nagasaki University, Nagasaki (Japan), 4. The University of Tokyo Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA), The University of Tokyo (Japan), 5. TERUMO Corporation, Medical Care Solutions Company, Pharmaceutical Solutions Division, R&D (Japan), 6. Department of Microbiology and Immunology, McGill University, Montreal, QC (Canada), 7. Division of Emerging and Transfusion Transmitted Diseases, CBER, FDA, Silver Spring, MD, 20993 (United States of America), 8. Department of Pathology, The Ohio State University, Columbus, Ohio (United States of America))

[P1-55]Validation of AI-predicted Dengue virus-specific HLA class I epitopes for vaccine development.

*SHARA BAKYTBEK1,2,3, Farzaneh Valanezhad1,2,3, Ayako Hyuga1,2,3, Shin-Ichi Inoue2,4, Yui Katsuyuki5, Shusaku Mizukami3,6, Risa Nakamura1,2,3, Kazuhide Onoguchi7, Sebastian Kapell8,9, Kouichi Morita3,10, Shinjiro Hamano1,2,3 (1. Department of Parasitology, Institute of Tropical Medicine (NEKKEN), The Joint Usage/Research Center on Tropical Disease, Nagasaki University, Nagasaki (Japan), 2. Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki (Japan), 3. The Vaccine Research and Development Center, DEJIMA Infectious Disease Research Alliance (DIDA), Nagasaki University, Nagasaki (Japan), 4. Department of Molecular Microbiology and Immunology, Division of Immunology, Nagasaki University, Nagasaki (Japan), 5. SHIONOGI Global Infectious Diseases Division Institute of Tropical Medicine, Nagasaki University, Nagasaki (Japan), 6. Department of Immune Regulations, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki (Japan), 7. AI Drug Development Division, NEC Corporation, Tokyo (Japan), 8. Department of Vaccine Informatics, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki (Japan), 9. NEC OncoImmunity AS, Ullernchausseen 64/66, 0379, Oslo (Norway), 10. Department of Virology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Nagasaki (Japan))

[P1-57]安全で効果的なワクチンを志向した脾臓B細胞標的mRNA搭載脂質ナノ粒子
Splenic B cell-targeting mRNA-loaded lipid nanoparticles for safe and effective vaccine delivery

*Yuichi Suzuki1, Yusuke Sato1, Hideyoshi Harashima1 (1. Faculty of Pharmaceutical Sciences, The University of Hokkaido (Japan))

[P1-59]Elucidation of the pathogenic mechanism(s) of SARS-CoV-2 infection by using aged C57BL/6J mice.

*Hiroshi Ueki1,2,3, Maki Kiso1, Shun Iida4, Tadaki Suzuki4, Yoshihiro Kawaoka1,2,3,5 (1. Division of Virology, Institute of Medical Science, University of Tokyo (Japan), 2. The University of Tokyo, Pandemic Preparedness, Infection and Advanced Research Center (Japan), 3. Center for Global Viral Diseases, National Center for Global Health and Medicine Research Institute (Japan), 4. Department of Pathology, National Institute of Infectious Diseases (Japan), 5. Department of Pathobiological Sciences, University of Wisconsin-Madison (United States of America))

[P1-61]SARS-CoV-2 infection primes cross-protective memory IgA in a MyD88- and MAVS-dependent manner

Moe KOBAYASHI1, Nene KOBAYASHI1, Kyoka DEGUCHI1, Seira OMORI1, *Takeshi ICHINOHE1 (1. Institute of Medical Science, The University of Tokyo (Japan))

[P1-63]Development of conditional replication system using Lassa virus glycoprotein-encoding retroviral vector in BSL2

*Yoshinao Kubo1, Manya Bakatumana Hans1, Osamu Kotani2, Hironori Sato2, Koya Ariyoshi1 (1. Institute of Tropical Medicine, Nagasaki University (Japan), 2. National Institute of Infectious Diseases (Japan))

[P1-65]クリミア-コンゴ出血熱ウイルス核タンパク質によるmiRNA機能の変調
Disturbance of miRNA biogenesis by nucleocapsid protein of Crimean-Congo hemorrhagic fever virus

Minato Hirano1, *Kentaro YOSHII1, Hirotaka Takahashi2 (1. National Research Center for the Control and Prevention of Infectious Diseases,Nagasaki university (Japan), 2. Proteo-Science Center, Ehime University (Japan))

[P1-67]Exploring viral antigenic evolution with an AI-driven predictive framework

*Shusuke Kawakubo1, Hiroaki Unno1, Adam Strange1, Spyros Lytras1, Jumpei Ito1, Kei Sato1 (1. Institute of Medical Science, The University of Tokyo (Japan))

[P1-69]The relationship between RNA virus infection and host nonsense-mediated mRNA decay

*Ryo Komorizono1, Yuki Furuse1 (1. UTOPIA, The University of Tokyo (Japan))

[P1-71]Establishment of evaluation system antiviral agents against for Mpox virus (MPXV)

*Akihiko Sato1,2,3, Shinji Kusakabe1,3, Kei Konishi1,3, Takao Shishido3, Michihito Sasaki1,2, Yasuko Orba1,2,4, Hirofumi Sawa1,2,4 (1. International institute for Zoonosis Control,Hokkaido University (Japan), 2. Institute for Vaccine Research and Development, Hokkaido University (Japan), 3. Shionogi & Co. Ltd. (Japan), 4. One Health Research Center, Hokkaido University (Japan))

[P1-75]Assessing the impact of antigenic diversity of Rabies virus glycoproteins in the Americas: Implications for vaccine design

*Cassia Sousa Moraes1, Gabriel Gonzalez2, Koshiro Tabata1, Shinji Saito1, Hirofumi Sawa1, Yukari Itakura1 (1. Division of Biological Response Analysis, IVReD, Hokkaido University (Japan), 2. Division of Research Support, IVReD, Hokkaido University (Japan))

[P1-77]Regulatory mechanism for host-cell contact-dependent T3SS gene expression in Vibrio parahaemolyticus

*Sarunporn Tandhavanant1,2, Hiroyuki Terashima1,3, Hirotaka Hiyoshi1, Dhira Saraswati Anggramukti4, Nopadol Precha2,5, Tetsuya Iida4, Shigeaki Matsuda4, Narisara Chantratita2, Toshio Kodama1 (1. Institute of Tropical Medicine, Nagasaki University (Japan), 2. Faculty of Tropical Medicine, Mahidol University (Thailand), 3. College of Pharmacy, Kinjo Gakuin University (Japan), 4. Research Institute for Microbial Diseases, Osaka University (Japan), 5. School of Public Health, Walailak University (Thailand))

[P1-79]トランスポゾンの活性化による共生・病原性細菌の初期進化過程の実験室進化
Laboratory evolution of early symbiont and pathogen evolution by transposon activation

*Yuki Kanai1, Norikazu Ichihashi1, Atsushi Shibai2, Naomi Yokoi2, Saburo Tsuru1, Chikara Furusawa1,2 (1. The University of Tokyo (Japan), 2. RIKEN (Japan))

[P1-81]Six members of multigene families in Plasmodium knowlesi are associated with rosette formation

*Chukwuma Stephen Ezenwanne1,2,3, Huai Chuang3, Taeko Naruse1,2,3, Yuko Katakai4, Satoru Kawai5, Bruce Russell3,6, Miako Sakaguchi7, Osamu Kaneko1,2,3 (1. Graduate School of Biomedical Science, Nagasaki University, Nagasaki, Japan (Japan), 2. School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki (Japan), 3. Department of Protozoology, Institute of Tropical Medicine, Nagasaki University, Nagasaki (Japan), 4. The Corporation for Production and Research of Laboratory Primates, Ibaraki (Japan), 5. Department of Tropical Medicine and Parasitology, Dokkyo Medical University, Tochigi (Japan), 6. Department of Microbiology and Immunology, University of Otago (New Zealand), 7. Central Laboratory, Institute of Tropical Medicine, Nagasaki University, Nagasaki (Japan))

[P1-83]Characterising Influenza epidemiology and dynamycis at the swine-human interface in Cambodia: The PigFluCam+ project

*Arata Hidano1,6, Hannah R Holt1, Sothyra Tum2, Monidarin Chou3, Ty Chhay4, William Leung1, PigFluCam+ Consortium1,2,3,4,5, Yvonne Su5, Gavin JD Smith5, James W Rudge1 (1. London School of Hygiene and Tropical Medicine (UK), 2. National Animal Health and Production Research Institute (Cambodia), 3. University of Health Sciences (Cambodia), 4. Livestock Development for Community Livelihood (Cambodia), 5. Duke-NUS Medical School (Singapore), 6. Nagasaki University (Japan))

[P1-85]プラットフォーム試験における非同時対照データ利用時の時間的傾向バイアスを調整するハイブリッド対照法
A hybrid control approach to adjust for time trends bias due to non-concurrent control data in a platform trial.

*Yui Kimura1,2, Kohei Uemura2, Junki Mizusawa3, Taro Shibata3, Kousuke Kashiwabara1 (1. Clinical Research Promotion Center, The University of Tokyo Hospital (Japan), 2. Department of Biostatistics & Bioinformatics, Interfaculty Initiative in Information Studies, The University of Tokyo (Japan), 3. Center for Research Administration & Support, National Cancer Center (Japan))

[P1-87]A Protein Language Model for Exploring Viral Fitness Landscapes

*Ito Ito Jumpei1, Adam Strange1, Wei Liu1, Gustav Joas1, Spyros Lytras1, Kei Sato1 (1. The Institute of Medical Science, The University of Tokyo (Japan))

[P1-89]Disruption of CCDC188 leads to male infertility with defects in the sperm head-neck connection in mice

*Yumiao Qiu1,2, Keisuke Shimada1, Kaito Yamamoto1, Masahito Ikawa1,2,3,4 (1. Research Institute for Microbial Diseases, Osaka university (Japan), 2. Graduate School of Medicine, Osaka university (Japan), 3. The Institute of Medical Science, The University of Tokyo (Japan), 4. Center for Infectious Disease Education and Research, Osaka university (Japan))

[P1-91]Development of a device-free CRISPR diagnostic platform for emerging pandemics

*Rika Hirano1, Kazuto Yoshimi1, Koji Asano1, Kohei Takeshita2, Ken J. Ishii1, Kei Sato1, Tomoji Mashimo1 (1. Institute of Medical Science, The University of Tokyo (Japan), 2. RIKEN Spring-8 Center (Japan))

[P1-93]Genetics of immune response in monocytes from Japanese healthy donors

*Matteo Guerrini1, Hiroaki Hatano2,3, Akari Suzuki1, Yasuhiro Murakawa4, Kazuyoshi Ishigaki2,3, Kazuhiko Yamamoto1 (1. Laboratory for Autoimmune Diseases, RIKEN Center for Integrative Medical Sciences (Japan), 2. Laboratory for Human Immunogenetics, RIKEN Center for Integrative Medical Sciences (Japan), 3. Department of Microbiology and Immunology, Keio University School of Medicine (Japan), 4. RIKEN-IFOM Joint Laboratory for Cancer Genomics, RIKEN Center for Integrative Medical Sciences (Japan))

[P1-95]BMI層別化により2型糖尿病の遺伝的予測精度が最適化されることを示したバイオバンク横断的研究
Body mass index stratification optimizes polygenic prediction of type 2 diabetes in cross-biobank analyses

*Takafumi Ojima1,2,3,4, Shinichi Namba1,2,3, Ken Suzuki1,2, Kenichi Yamamoto2, Kyuto Sonehara1,2,3, Akira Narita4, Yoichiro Kamatani1, Gen Tamiya3,4, Masayuki Yamamoto4, Toshimasa Yamauchi1, Takashi Kadowaki5, Yukinori Okada1,2,3 (1. The University of Tokyo (Japan), 2. Osaka University (Japan), 3. RIKEN (Japan), 4. Tohoku University (Japan), 5. Toranomon Hosipital (Japan))

[P1-97]Integrative Single-Cell Analysis and Spatial Mapping of B Cell Repertoires in Gastric Cancer for Antigen Discovery in Immune Responses

*Yichen Jiang1, Ayumu Tsubosaka1, Miwako Kakiuchi1, Daisuke Komura1, Hiroto Katoh1, Shumpei Ishikawa1 (1. Department of Preventive Medicine, The University of Tokyo (Japan))

[P1-99]Pre-implantation genetic testing by polygenic risk scores selects different embryos across score construction methods with randomness

*Shinichi Namba1,2,3, Masato Akiyama4, Haruka Hamanoue5, Kazuto Kato2, Minae Kawashima6, Itaru Kushima7, Koichi Matsuda1, Masahiro Nakatochi7, Soichi Ogishima8, Kyuto Sonehara1,2,3, Ken Suzuki1,2, Atsushi Takata9, Gen Tamiya8,10, Chizu Tanikawa1, Kenichi Yamamoto2, Natsuko Yamamoto2, Norio Ozaki7, Yukinori Okada1,2,3 (1. The University of Tokyo (Japan), 2. Osaka University (Japan), 3. RIKEN Center for Integrative Medical Sciences (Japan), 4. Kyushu University (Japan), 5. Yokohama City University Hospital (Japan), 6. ROIS-DS (Japan), 7. Nagoya University (Japan), 8. Tohoku University (Japan), 9. RIKEN Center for Brain Science (Japan), 10. RIKEN Center for Advanced Intelligence Project (Japan))

[P1-101]Single-cell eQTL mapping identifies cell state-dependent genetic regulation of transcriptional profiles in immune cells from 234 Japanese including COVID-19 patients and healthy subjects

*Ryuya Edahiro1,2, Go Sato1,2, Yuya Shirai1,2, Tatsuhiko Naito1,2, Kyuto Sonehara1,2,3, Yoshihiko Tomofuji1,2,3, Kenichi Yamamoto1, Shinichi Namba1,2,3, Noah Sasa1, Genta Nagao3,4, Ho Namkoong4, Koichi Fukunaga4, Takayoshi Morita1, Yasuhirko Kato1, Haruhiko Hirata1, Yoshito Takeda1, Daisuke Okuzaki5, Atsushi Kumanogoh1,5, Yukinori Okada1,2,3,5 (1. Osaka University Graduate School of Medicine (Japan), 2. RIKEN Center for Integrative Medical Sciences (Japan), 3. Graduate School of Medicine, the University of Tokyo (Japan), 4. Keio University School of Medicine (Japan), 5. Immunology Frontier Research Center (WPI-IFReC), Osaka University (Japan))

[P1-103]Combination therapy of anti-PD-1 antibody and replication-competent recombinant herpes simplex virus G47Δ in a mouse lung cancer model

*YOSHINORI SAKATA1, MIWAKO IWAI1, TOMOKI TODO1 (1. Division of Innovative Cancer Therapy, The Institute of Medical Science, The University of Tokyo (Japan))

[P1-105]Imaging expression dynamics of mRNA vaccines

*Hotaka Kobayashi1,2,3 (1. IQB, The University of Tokyo (Japan), 2. IAMS, Tokushima University (Japan), 3. PRESTO, JST (Japan))

[P1-107]化学修飾mRNAを合成する技術の開発
Development of Technology for Synthesizing Chemically Modified mRNA

*Koji Hashimoto1 (1. Graduate School of Arts and Sciences, The University of Tokyo (Japan))

[P1-109]細胞外の生体分子を検知し、それに応じて治療用タンパク質を産生する次世代mRNA医薬の開発
Extracellular biomolecule-responsive mRNA drugs for conditional therapeutic protein production

*Hideyuki Nakanishi1,2, Keiji Itaka1,2 (1. Center for Infectious Disease Education and Research (CiDER), Osaka University (Japan), 2. Department of Biofunction Research, Laboratory for Biomaterials and Bioengineering, Institute of Integrated Research, Institute of Science Tokyo (Japan))

[P1-111]感染症による重症化因子の解明を目指したマルチオミクス
Multi-omics approach to elucidate risk factors for severity of infectious diseases

*Suzumi M Tokuoka1, Fumie Hamano1, Ayako Kobayashi1, Yoshiya Oda1 (1. The University of Tokyo (Japan))

[P1-113]Enhancement of Photo-Activatable Transcription Factor in Mammalian Cells

*Shinji C. Nagasaki1, Itaru Imayoshi1,2,3 (1. Laboratory of Deconstruction of Stem Cells, Institute for Life and Medical Sciences (LiMe), Kyoto University (Japan), 2. Laboratory of Brain Development and Regeneration, Graduate School of Biostudies, Kyoto University (Japan), 3. Center for Living Systems Information Science, Graduate School of Biostudies, Kyoto University (Japan))

[P1-115]Proteomic Landscape of Immune Cell Subsets at Scale

*Koshi Imami1, Akari Suzuki1, Takahiro Nishino1,2, Hiroaki Hatano1, Yoshihiko Tomofuji1,6, Jun Seita1, Kazuyoshi Ishigaki1,2, Yukinori Okada1,3,4,5,6, Kazuhiko Yamamoto1 (1. Center for Integrative Medical Sciences, RIKEN (Japan), 2. Department of Microbiology and Immunology, Keio University School of Medicine (Japan), 3. Department of Statistical Genetics, Osaka University Graduate School of Medicine (Japan), 4. Integrated Frontier Research for Medical Science Division, Institute for Open and Transdisciplinary Research Initiatives, Osaka University (Japan), 5. Center for Infectious Disease Education and Research (CiDER), Osaka University (Japan), 6. Department of Genome Informatics, Graduate School of Medicine, The University of Tokyo (Japan))

[P1-117]The characteristics of in vivo senescent somatic cells in aging and cancer

*David Wang1, Makoto Nakanishi1 (1. Institute of Medical Science, The University of Tokyo (Japan))

[P1-119]創薬基盤としての寄生虫ヌクレオソームの構造と性質
Structure and properties of parasite nucleosomes as a drug discovery platform

*Shoko Sato1, Mariko Dacher1, Yoshimasa Takizawa1, Hitoshi Kurumizaka1 (1. Institute for Quantitative Biosciences, The University of Tokyo (Japan))

[P1-121]インフルエンザウイルスのクライオ電子顕微鏡観察
Cryo-EM observations of influenza viruses

*Shunsuke Kita1, Souta Kobayashi1, Toshiki Sekiya2, Naoki Nomura2, Chimuka Handabile2, Masashi Shingai2, Hiroshi Kida2, Katsumi Maenaka1 (1. Hokkaido University, Faculty of Pharmaceutical Sciences (Japan), 2. Hokkaido University, Inter. Inst. Zoonosis Control (Japan))

[P1-123]カニクイザル卵胞刺激ホルモンの作出及びカニクイザルの人工繁殖への適用
Production of recombinant cynomolgus follicle stimulating hormone and its application for artificial breeding of the monkey.

*Toshifumi Morimura1, Hideaki Tsuchiya1, Chizuru Iwatani1, Nao Maeda1, Yuko Abiko1, Eiichi Okamura1, Masatsugu Ema1 (1. Research Center for Animal Life Science, Shiga University of Medical Sceince (Japan))

[P1-125]HepaSH細胞:再現性の高い細胞資源としてのヒト初代肝細胞の標準化
HepaSH cells; Standardization of primary human hepatocytes as a highly reproducible cell source.

*Yuichiro Higuchi1, Shotaro Uehara1, Nao Yoneda1, Kazuhiro Murai2, Akinori Takemura3, Seiichi Ishida4, Mina Ogawa5, Hiroshi Suemizu1 (1. Liver Engineering Laboratory, Central Institute for Experimental Medicine and Life Science (Japan), 2. Osaka University (Japan), 3. Chiba University (Japan), 4. Sojo University (Japan), 5. Toronto University (Canada))

[P1-127]コモンマーモセットを用いた研究の加速を目的としたモノクローナル抗体の開発
Development of monoclonal antibodies to accelerate research using common marmosets

*Kenya Sato1, Ryoji Ito1, Mamoru Ito1, Erika Sasaki1 (1. Central Institute for Experimental Medicine and Life Science (Japan))

[P1-129]Modified nucleoside triphosphate synthesis for the development of an mRNA vaccine

*Md Ariful Islam1,2, Taslima Rahman Chowdhury1,2, Hideyuki Nakanishi1,3, Keiji Itaka1,3, Satoshi Obika1,2 (1. Center for Advanced Modalities and DDS, Osaka University (Japan), 2. Graduate School of Pharmaceutical Sciences, Osaka University (Japan), 3. Institute of Science Tokyo (Japan))

[P1-131]Light-induced delivery of mRNA to target cells

*Takahiro Nomoto1, Daiki Tokura1 (1. Graduate School of Arts and Sciences, The University of Tokyo (Japan))

[P1-135]Enhanced Image Processing Algorithm with CNN Integration for Tracking Porphyromonas gingivalis Outer Membrane Vesicle Dynamics in Periodontal Pathogenesis

*Seohyun Lee1, Hideaki Ota2, Hideo Higuchi3, Takehiro Yamaguchi4, Ryoma Nakao4 (1. Interfaculty Initiative in Information Studies, The University of Tokyo (Japan), 2. Graduate School of Science, The University of Tokyo (Japan), 3. New Industry Creation Hatchery Center, Tohoku University (Japan), 4. National Institute of Infectious Diseases (Japan))

[P1-137]Predicting antibody-antigen interactions using the novel high-throughput interaction analysis system

Kihoon Kim1, *Ryo Matsunaga1, Takanori Yokoo1, Makoto Nakakido1, Kouhei Tsumoto1 (1. The University of Tokyo (Japan))

[P1-139]Survey of public attitudes towards vaccine development through outreach activities

*Yuji Watanabe1, Akiko Takahashi2, Jin Higashijima3, Hiroshi Mizuuchi1 (1. Chiba University, Synergy Institute for Futuristic Mucosal Vaccine Research and Development (Japan), 2. Artificial Intelligence Medicine, Graduate School of Medicine, Chiba University (Japan), 3. College of Liberal Arts and Sciences, Chiba University (Japan))

[P1-141]Effective Transcatheter Intracoronary Delivery of mRNA-Lipid Nanoparticles Targeting The Heart

*Kazuma Handa1, Masashi Kawamura1, Masao Sasai1, Takashi Matsuzaki2, Akima Harada1, Lisa Fujimura1, Julia Whitehouse1, Anri Fujishiro3, Kunio Hirano3, Kenji Miki4, Shigeru Miyagawa1,4 (1. Department of Cardiovascular Surgery, Osaka University (Japan), 2. Department of DDS Pharmaceutical Development, Osaka University Graduate School of Medicine (Japan), 3. Terumo Corporation, Innovation Center, Kanagawa (Japan), 4. Premium Research Institute for Human Metaverse Medicine (WPI-PRIMe), Osaka University (Japan))

[P1-143]Detection of microorganisms by Nanopore sequencing with environmental samples

*Toshifumi Imagawa1 (1. Graduate School of Biomedical Sciences, Nagasaki University (Japan))

[P1-145]パンデミックワクチン開発に向けた準備:CAMaDの事例
Preparation for Pandemic Vaccine Development: A Case of CAMaD

*Junetsu Igarashi1, Kimiyo Kamamoto-Shono1, Akiko Takechi1, Yoshihiro Takashima1, Hideo Takasu1, Yutaka Saisho1, Noriko Tomita1, Akira Kikuchi2, Yoshiya Hosokawa2, Takayuki Yoshioka1 (1. Center for Advanced Modalities and Drug Delivery Systems (CAMaD) (Japan), 2. Center for Infectious Disease Education and Research (CiDER) (Japan))

[P1-147]Functional characterization of extracellular particles during viral infection by high-resolution single-particle mapping and sorting

*Tomoya Hayashi1,2,3, Shuntaro Shimizu1,2,3, Koji Sakamoto4, Naozumi Hashimoto5, Kouji Kobiyama1,2,3, Hideo Negishi1,2,3, Burcu Temizoz1,2,3, Cevayir Coban1,2,3, Ken J Ishii1,2,3 (1. The Institute of Medical Science, The University of Tokyo (IMSUT) (Japan), 2. International Vaccine Design Center, IMSUT (Japan), 3. The University of Tokyo Pandemic Preparedness, Infection and Advanced Research Center (UTOPIA) (Japan), 4. Department of Respiratory Medicine, Nagoya University Graduate School of Medicine (Japan), 5. Department of Respiratory Medicine, Fujita Health University (Japan))