[P2] Poster Session Core Time (偶数番号)

R&D IIIVirology

[P2-54] 変異株に対する交差反応性向上を目的とした構造情報に基づく受容体結合ドメインを閉じたSARS-CoV-2スパイク蛋白質の設計および評価
Structure-guided design of receptor-binding domain-down SARS-CoV-2 spike protein to enhance cross-reactivity against variants

*Takuya Hemmi^1,2, Saya Moriyama³, Akira Ainai², Hisano Yajima¹, Rin Shirota¹, Tomo Nomai⁴, Shunsuke Kita⁴, Satoru Nagatoishi⁵, Kouhei Tsumoto⁵, Yukihiko Sugita⁶, Takeshi Noda⁶, Katsumi Maenaka⁴, Yoshimasa Takahashi³, Tadaki Suzuki^2,7, Takao Hashiguchi^1,8 (1. Laboratory of Medical virology, Institute for Life and Medical Sciences, Kyoto University (Japan), 2. Department of Infectious Disease Pathology, National Institute of Infectious Diseases, Japan Institute for Health Security (Japan), 3. Research Center for Vaccine Development, National Institute of Infectious Diseases, Japan Institute for Health Security (Japan), 4. Laboratory of Biomolecular Science and Center for Research and Education on Drug Discovery, Faculty of Pharmaceutical Sciences, Hokkaido University (Japan), 5. Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, Tokyo (Japan), 6. Laboratory of Ultrastructural Virology, Institute for Life and Medical Sciences, Kyoto University, Kyoto (Japan), 7. Department of Infectious Disease Pathobiology, Graduate School of Medicine, Chiba University (Japan), 8. Kyoto University Immunomonitoring Center, Kyoto University (Japan))

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