講演情報
[IL6]生体分子凝縮体：ゲノム生物学とがん生物学における意義
○鈴木 洋1,2 (1.名古屋大学 大学院医学系研究科 分子腫瘍学, 2.名古屋大学 糖鎖生命コア研究所)
Biomolecular condensates, often induced by liquid-liquid phase separation (LLPS) and intrinsically disordered regions (IDRs) of many proteins, have emerged as an important topic in many fields of biology and medicine. Various cellular processes, including cellular signaling, gene regulation, and autophagy, have been suggested to be associated with LLPS. In the field of gene regulation, some unique properties of super-enhancers, an importance subclass of enhancers essential for cell identity control, have suggested an intriguing link between gene regulation and biomolecular condensates. In addition, multivalent weak cooperative interactions (WCI) mediated by LLPS and IDRs provides new insights into how biological systems are capable of mediating specificity of many biological processes and undergoing evolutionary changes robustly. Furthermore, alterations in biomolecular condensates appear to have multifaceted important roles in cancer biology. In this symposium, we discuss the importance of condensate biology in genome biology and cancer biology by introducing our recent findings regarding super-enhancers, transcriptional condensates, and genome diversity of IDRs in human health and diseases including cancers.