講演情報
[OE7-3]ゲノムワイド関連解析データを用いた乾癬の遺伝的相関解析
○小河 浩太郎1,2, Tsoi Lam3, 田中 宏明4, 金井 仁弘5, Stuart Philip3, Nair Rajan3, 田中 良哉4, 望月 秀樹2, Elder James3, 岡田 随象1,6,7,8 (1.大阪大学大学院医学系研究科 遺伝統計学, 2.大阪大学大学院医学系研究科 神経内科学, 3.University of Michigan Medical School, Ann Arbor, MI, USA., 4.産業医科大学 第一内科, 5.Broad Institute of MIT and Harvard, USA, 6.東京大学大学院医学系研究科 遺伝情報学, 7.理化学研究所生命医科学研究センター システム遺伝学, 8.大阪大学免疫学フロンティア研究センター 免疫遺伝学)
Epidemiological studies have reported comorbidity of psoriasis with many immune-related diseases, coronary artery disease, and metabolic traits. However, cross-trait relationship of genetic backgrounds between these traits and psoriasis has been elusive. Here, we collected the large-scale European-ancestry genome-wide association studies summary statistics of psoriasis and 21 traits and diseases, which have been reported to have close relationship to psoriasis in epidemiological studies. Then we conducted cross-trait genetic correlation analysis using LD score regression.
Pairwise genetic correlation analysis identified that coronary artery disease, immune-related diseases (Crohn's disease, ulcerative colitis, and schizophrenia), and metabolic traits (type 2 diabetes, body mass index, triglyceride, and HDL-cholesterol) were significantly associated with psoriasis. Cell-type specific analysis identified that CD4+CD25-IL17+PMA Ionomycin simulated Th17 primary cells are most significantly associated with psoriasis. Our study revealed such cell-type specificity by disentangling genetic links among psoriasis and relevant cell types without prior biologicalknowledge. Phenotype-cell type network analysis identified connections between allergic and autoimmune diseases and immune-related cell types, providing additional cell types contributing to psoriasis genetics.
Pairwise genetic correlation analysis identified that coronary artery disease, immune-related diseases (Crohn's disease, ulcerative colitis, and schizophrenia), and metabolic traits (type 2 diabetes, body mass index, triglyceride, and HDL-cholesterol) were significantly associated with psoriasis. Cell-type specific analysis identified that CD4+CD25-IL17+PMA Ionomycin simulated Th17 primary cells are most significantly associated with psoriasis. Our study revealed such cell-type specificity by disentangling genetic links among psoriasis and relevant cell types without prior biologicalknowledge. Phenotype-cell type network analysis identified connections between allergic and autoimmune diseases and immune-related cell types, providing additional cell types contributing to psoriasis genetics.