講演情報
[PE2-2]コロナ制圧タスクフォース：日本におけるCOVID-19の宿主遺伝学的解析のための全国コンソーシアム
○南宮 湖1,2, コロナ制圧タスクフォース 研究グループ2 (1.慶應義塾大学 医学部 感染症学教室, 2.コロナ制圧タスクフォース)
To elucidate the host genetic loci affecting severity of SARS-CoV-2 infection, or Coronavirusdisease 2019 (COVID-19), is an emerging issue in the face of the current devastatingpandemic. Here, we report a genome-wide association study (GWAS) of COVID-19 in aJapanese population led by the Japan COVID-19 Task Force, as one of the initial discoveryGWAS studies performed on a non-European population. Enrolling a total of 2,393 casesand 3,289 controls, we not only replicated previously reported COVID-19 risk variants (e.g.,LZTFL1, FOXP4, ABO, and IFNAR2), but also found a variant on 5q35 (rs60200309-A atDOCK2) that was associated with severe COVID-19 in younger (＜65 years of age) patientswith a genome-wide significant p-value of 1.2 × 10-8(odds ratio = 2.01, 95% confidenceinterval = 1.58-2.55). This risk allele was prevalent in East Asians, including Japanese (minorallele frequency [MAF] = 0.097), but rarely found in Europeans. Cross-population Mendelianrandomization analysis made a causal inference of a number of complex human traits onCOVID-19. In particular, obesity had a significant impact on severe COVID-19. The presenceof the population-specific risk allele underscores the need of non-European studies ofCOVID-19 host genetics.