講演情報
[SL1]Circulating DNA: coming in all sizes and forms
○Yuk Ming Dennis Lo (The Chinese University of Hong Kong, Hong Kong, China)
Cell-free DNA in plasma has made possible the development of non-invasive prenatal testing (NIPT) and cancer liquid biopsies. My group is interested in the molecular characterisation of such molecules. Such molecules have been found to consist of short fragments of DNA. The fragmentation process resulting in such short fragments has been found to be non-random. The study of such fragmentation is now called fragmentomics. Very recently, through the use of single molecule sequencing, we have found that there is a previously undiscovered population of 'super long' cell-free DNA in plasma. The discovery of such molecules has opened up new possibilities for plasma-based molecular analysis.