[1LBA] Neuroanatomy, Neurophysiology, Neuronal cell biology Neurological disorders, Neuropathophysiology, brain inflammation

[1LBA-016] Genetic and Pharmacologic Enhancement of SUMO2 conjugation prevents and reverses cognitive impairments and synaptotoxicity in a preclinical model of Alzheimer’s disease.

^○Shinsuke Matsuzaki^1,2,3, Nadeeja Wijesekara^4,9, Elentina Argyrousi⁵, Hironori Takamura⁴, Kanayo Satoh⁴, Agnieszka Staniszewski⁵, Erica Acquarone⁵, Hiroto Yamauchi¹, Taiichi Katayama³, Ottavio Arancio^5,6, Luana Fioriti^5,7, Paul Fraser^4,8 (1.Graduate School of Health Sciences, Morinomiya University of Medical Sciences, 2.Morinomiya Inclusive Medical Sciences Research Institute, 3.United Graduate School of Child Development, Osaka University Osaka, Japan, 4.Tanz Centre for Research in Neurode¬¬generative Diseases University of Toronto, 5.Taub Institute for Research of Alzheimer’s Disease and the Aging Brain, Columbia University, 6.Department of Medicine, Columbia University, 7.Department of Neuroscience, Istituto di Ricerche Farmacologiche Mario Negri, 8.Department of Medical Biophysics, University of Toronto, 9.Ionis Pharmaceuticals, Carlsbad, CA)

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