General information

Announcements(1)

Program

Sessions

Search presentations

Download PDF for print

Timetable

Mon. Mar 17, 2025

Tue. Mar 18, 2025

Wed. Mar 19, 2025

web_header_en.png

web_icon.png

Profile management

Announcements

Bookmark

Program Type

Login required to view

Password required to view

Presentation Information

Session Details

To browse or post comments, you must log in.

You cannot post comments as it is outside the comment posting period.

This comment has been deleted. You cannot reply to this comment.

PDX Model Construction: Past Research and Future Prospects

JPS : Academic Planning Committee for Annual Meeting

In the field of drug discovery, there is a growing demand to improve the extrapolation of non-clinical data to clinical studies. This is necessary because there are often high dropout rates during clinical development, leading to a significant waste of R&D resources. Particularly in the field of oncology, the use of human tissues such as organoids and patient-derived tumor transplantation models has become increasingly crucial. Utilizing human tissues allows for the reduction of species differences and the acquisition of data with superior functional relevance.Furthermore, advancements in molecular biology and cell biology have provided insights into the immune cancer cycle, encompassing tumor growth, metastasis, invasion, and tumor cell death. Consequently, methods for drug discovery in oncology have evolved. It has also been reported that cancer stromal cells, including paraneoplastic macrophages and cancer-associated fibroblasts, play a vital role in cancer growth. Understanding the interaction between cancer cells and the surrounding stromal cells is of particular importance.In this symposium, the latest scientific advancements and technologies will be discussed, including evaluation systems that focus on the tumor microenvironment using human tissues.

Corporate Planning Symposium: Translational Research Using Human Cancer Tissues in Drug Discovery

APPW2025

Presentation Information

[1S04m-2]PDX Model Construction: Past Research and Future Prospects

Login required to view

Comment