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Mon. Mar 17, 2025

Tue. Mar 18, 2025

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Endoplasmic reticulum quality control system and neurodegenerative diseases resulting from its disruption

The cell membrane forms a fundamental part of all living cells and participates in a variety of physiological processes. The cell contains membrane-enclosed subcellular organelles such as the endoplasmic reticulum (ER) and Golgi apparatus, as well as endocytic organelles. The asymmetry between the inner and outer lipid bilayers is involved in cell physiology and cell death. Membrane proteins such as receptors, transporters, and channels exist at the cholesterol- and glycosphingolipids-enriched microdomains so-called lipid rafts, which function as signal transduction and vesicular transport platforms. The stabilization of lipid rafts is regulated by various molecules including galectins. The link between defects of ER proteostasis and pathological conditions, especially in neurodegenerative diseases, has recently attracted much attention. The aim of this symposium is to review membrane homeostasis and its molecular mechanisms, such as the organization of membrane microdomains, the quality control of membrane proteins, and the regulatory factors driving membrane dynamics. We also will discuss their pathophysiological roles and potential as novel therapeutic targets.

New findings in the molecular mechanisms of cell membrane homeostasis for the understanding of the pathophysiology and the exploration of novel drug targets

APPW2025

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[[OD]1S12m-3]Endoplasmic reticulum quality control system and neurodegenerative diseases resulting from its disruption

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