General information

Announcements(1)

Program

Sessions

Search presentations

Download PDF for print

Timetable

Mon. Mar 17, 2025

Tue. Mar 18, 2025

Wed. Mar 19, 2025

web_header_en.png

web_icon.png

Profile management

Announcements

Bookmark

Program Type

Login required to view

Password required to view

Presentation Information

Session Details

To browse or post comments, you must log in.

You cannot post comments as it is outside the comment posting period.

This comment has been deleted. You cannot reply to this comment.

Mechanistic insights into maintenance and disruption of membrane phosphatidylserine asymmetry in erythrocytes: A survival strategy during their lifespan

The cell membrane forms a fundamental part of all living cells and participates in a variety of physiological processes. The cell contains membrane-enclosed subcellular organelles such as the endoplasmic reticulum (ER) and Golgi apparatus, as well as endocytic organelles. The asymmetry between the inner and outer lipid bilayers is involved in cell physiology and cell death. Membrane proteins such as receptors, transporters, and channels exist at the cholesterol- and glycosphingolipids-enriched microdomains so-called lipid rafts, which function as signal transduction and vesicular transport platforms. The stabilization of lipid rafts is regulated by various molecules including galectins. The link between defects of ER proteostasis and pathological conditions, especially in neurodegenerative diseases, has recently attracted much attention. The aim of this symposium is to review membrane homeostasis and its molecular mechanisms, such as the organization of membrane microdomains, the quality control of membrane proteins, and the regulatory factors driving membrane dynamics. We also will discuss their pathophysiological roles and potential as novel therapeutic targets.

New findings in the molecular mechanisms of cell membrane homeostasis for the understanding of the pathophysiology and the exploration of novel drug targets

APPW2025

Presentation Information

[[OD]1S12m-4]Mechanistic insights into maintenance and disruption of membrane phosphatidylserine asymmetry in erythrocytes: A survival strategy during their lifespan

Login required to view

Comment