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Extrasynaptic α3β4-containing nicotinic acetylcholine receptors in the medial habenula–interpeduncular nucleus pathway in mice

Joint Session : The Japanese Society of Toxicology, <br>Sponsored by : Philip Morris Japan

Smoking serves as a primary risk factor for the onset of various diseases and pathological conditions, including cardiovascular and metabolic diseases, and also exerts significant adverse effects on the living environment on the earth. Despite the application of insurance treatments to break the habit and dependence on tobacco, nearly 70% of consumers are unable to quit smoking. To minimize the health and environmental damages caused by smoking, alternative methods such as heated tobacco and electronic cigarettes, which contain fewer harmful substances, have been developed alongside the concept of "harm reduction" and are becoming widespread worldwide. From a public health perspective, heated tobacco is increasingly recognized in various countries, particularly in Europe and North America, as a method to prevent many of the adverse effects of smoking. However, there is still insufficient understanding and difficulty in quantitatively demonstrating the actual impact of heated tobacco on human health. This symposium aims to invite experts in smoking science from industry, government, and academia to discuss understanding, challenges, and future prospects regarding tobacco harm reduction.

Smoking harm reduction towards achieving One Health

APPW2025

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[[OD]2S03a-3]Extrasynaptic α3β4-containing nicotinic acetylcholine receptors in the medial habenula–interpeduncular nucleus pathway in mice

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