General information

Announcements(1)

Program

Sessions

Search presentations

Download PDF for print

Timetable

Mon. Mar 17, 2025

Tue. Mar 18, 2025

Wed. Mar 19, 2025

web_header_en.png

web_icon.png

Profile management

Announcements

Bookmark

Program Type

Login required to view

Password required to view

Presentation Information

Session Details

To browse or post comments, you must log in.

You cannot post comments as it is outside the comment posting period.

This comment has been deleted. You cannot reply to this comment.

Morphological aspects of ER and membrane contacts

Calcium-activated chloride-channels (CaCCs) are highly expressed in the smooth muscle cells of a range of vital organs and tissues where they provide a depolarising force evoked by a rise in intracellular calcium. In the GI or urogenital tract the channel is primarily active in pacemaking cells that indirectly control the activity of the surrounding smooth muscle. In pericytes, cell that surround capillaries, CaCCs either promote pericyte contraction or lead to spontaneous transient depolarisations that are transmitted to the neighbouring smooth muscle cells. CaCCs are suggested therapeutic targets for a range of disorders, including hypertension, vascular dementia, lower urinary tract symptoms and functional GI disorders. Here, we will present recent advances in the identification of selective small molecule modulators of CaCCs that open up new avenues for the elucidation of coupling between the sarcoplasmic/endoplamic reticulum (SR/ER) and CaCCs in smooth muscles. We will highlight anatomical aspect of SR/ER-CaCC coupling, including the dynamic control of physical interactions between the SR/ER and the plasmalemmal formations in physiology and disease. Current knowledge of the conversion of SR/ER calcium release into smooth muscle excitation will also be covered, focusing on CaCCs to develop a future research as well as therapeutic strategy.

Conversion of SR/ER Ca2+ release into smooth muscle excitation by Ca2+-activated Cl- channels

APPW2025

Presentation Information

[2S08a-4]Morphological aspects of ER and membrane contacts

Login required to view

Comment