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Mon. Mar 17, 2025

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Exploring the molecular mechanisms to modulate temperature sensitivity of TRPM2

There are now 11 thermosensitive TRP channels since the cloning of the first thermosensitive TRP channel TRPV1, a capsaicin receptor in 1997. The structures of all the 11 thermosensitive TRP channels are clarified at an atomic level mainly with a Cryo-EM technique. The 2021 Nobel Prize in Physiology or Medicine was given to Prof. David Julius in University of California at San Francisco for the discovery of temperature receptors, TRPV1 and TRPM8. Thermosensitive TRP channels are expressed in all the cells and tissues in our body, and involved in various physiological functions. However, it is still not understood how temperature opens thermosensitive TRP channels. Here we have several experts of the thermosensitive TRP channel research and want to discuss the future of the thermosensitive TRP channel research upon listening to their recent works.

Cutting Edge of the Thermosensitive TRP Channel Research

APPW2025

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[2S10a-1]Exploring the molecular mechanisms to modulate temperature sensitivity of TRPM2

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