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Mon. Mar 17, 2025

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Whole-brain functional omics approach in <em>C. elegans</em>: single-cell gene expression, circuit mapping, activity imaging and manipulation

Recent years have seen remarkable development in methods for measuring and manipulating cell dynamics and activity using light. The development of biological two-photon microscopy techniques and probes, as well as cell activity manipulation methods using optogenetics, are revealing a variety of biological phenomena. In neuroscience, it is now possible to measure 10,000 single neurons by imaging them widely and rapidly, and in immunology, cellular dynamics can be observed in individual organs. Furthermore, research is being conducted to demonstrate the measurement results of these cells by manipulating channels and G protein-coupled receptors with light using optogenetic and chemogenetic techniques, or by manipulating specific receptors using chemogenetic techniques. Therefore, this proposal focuses on the development of these technologies and their biological applications, and aims to discover ecological phenomena from a new angle by integrating them.

CuttingEdge technology of Photobiology revealing life phenomena

APPW2025

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[[OD]3S09m-3]Whole-brain functional omics approach in C. elegans: single-cell gene expression, circuit mapping, activity imaging and manipulation

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