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Mon. Mar 17, 2025

Tue. Mar 18, 2025

Wed. Mar 19, 2025

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Elucidating the neural and molecular mechanisms of neural circuit reorganization after brain injury

Our symposium highlights cutting-edge research on recovery mechanisms and novel therapies for CNS damage. Vicent Cheung presents the theory of motor modularity, focusing on muscle synergies as coordination modules underlying motor control. Encoded by spinal interneurons, these modules exhibit plasticity and serve as markers and targets for personalized rehabilitation. Kazuhiko Seki examines CNS adaptation to musculoskeletal changes using a tendon transfer model in non-human primates, revealing a multi-phase neural adaptation process. Masaki Ueno discusses the neural substrates and molecular mechanisms crucial for reorganization and recovery following brain injury, identifying fundamental therapeutic targets for CNS rehabilitation. Michiaki Suzuki introduces chemogenetic activation of spinal convergent pathways as a novel therapeutic strategy.

Rehabilitation Renaissance

APPW2025

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[3S11a-3]Elucidating the neural and molecular mechanisms of neural circuit reorganization after brain injury

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