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Mon. Mar 17, 2025

Tue. Mar 18, 2025

Wed. Mar 19, 2025

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Role and origins of peripheral HMGB1 in the pathogenesis of intractable pain

Human pain is classified into 3 types of pain, i.e. nociceptive, neuropathic and nociplastic pain, whereas combination of different types of pain could contribute to the development of intractable pain. In the pain pathway from the peripheral tissue or organs through the spinal cord to the brain, a variety of humoral factors derived from neuronal and non-neuronal cells including glia and inflammatory cells promote or modulate transmission of pain information. On the other hand, a variety of pain can alter the neuronal excitability in different brain areas, which may lead to mental dysfunction. In this symposium, 4 ingenious speakers will provide overview of state-of-the-art evidences concerning central and peripheral mechanisms underlying different types of pain. Speakers #1 and #4 will describe the novel findings regarding peripheral humoral factors involved in the development or modulation of intractable pain, and speakers #2 and #3 will show the updated evidences for the altered neuronal functions or humoral factor generation in specific higher brain areas caused by pain or peripheral inflammation. The organizers and speakers, in collaboration with the audience, will thoroughly discuss appropriate research directions for in-depth understanding of pain mechanisms.

Multi-angled analyses of central and peripheral mechanisms underlying different types of pain

APPW2025

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[3S11m-4]Role and origins of peripheral HMGB1 in the pathogenesis of intractable pain

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