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Mon. Mar 17, 2025

Tue. Mar 18, 2025

Wed. Mar 19, 2025

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Neural mechanisms underlying spontaneous recovery from temporary depressive state

Many stress-related disorders, including major depressive disorder and post-traumatic stress disorder (PTSD), are not adequately treated with currently available antidepressants and anxiolytics due to the complexity of their pathophysiology. Recently, considerable research and development efforts are being made to develop novel therapeutic agents based on mechanisms different from conventional monoaminergic antidepressants and benzodiazepine anxiolytics, as evidenced by clinical reports demonstrating the efficacy of the NMDA receptor antagonist ketamine in treatment-resistant depression and PTSD. In addition, studies on the mechanisms of stress resilience (resistance to and recovery from stress) have been actively conducted. This symposium aims to introduce and discuss novel therapeutic targets identified mainly through mouse studies focusing on the pathophysiology of stress-related disorders, the neural mechanisms of stress resilience, those underlying the effects of exercise on emotion, and the mechanisms of action of drug candidates.

Discovery of novel therapeutic targets for stress-related disorders

APPW2025

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[3S14a-3]Neural mechanisms underlying spontaneous recovery from temporary depressive state

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