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Mon. Mar 17, 2025

Tue. Mar 18, 2025

Wed. Mar 19, 2025

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Analysis of the Role of Orexin Receptor Signaling in Animal Behaviors by Methods for Manipulating GPCR-mediated Pathways in Freely Moving Mice

Recent breakthroughs in research technologies for G protein-coupled receptors (GPCRs) in various fields, such as cryo-electron microscopy, single-molecule imaging, and optogenetics, have provided opportunities to reveal several pharmacological actions of small molecules. These actions include classical orthosteric effects, allosteric modulation, and biased actions that preferentially elicit specific signals. Advancing research in GPCR drug discovery will require summarizing recent findings from each field and achieving a cross-disciplinary understanding from single molecules and receptor structures to animal behavior. Therefore, inviting experts from diverse fields; medicinal chemistry, structural biology, biophysics, and neuropharmacology, to this symposium would lead to a “concert" of a GPCR research community consisting of a heterogeneous audience with a multilayered understanding of GPCRs.

Advancing Drug Discovery Through Multilayered Crosstalk of GPCRs

APPW2025

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[[OD]3S15a-4]Analysis of the Role of Orexin Receptor Signaling in Animal Behaviors by Methods for Manipulating GPCR-mediated Pathways in Freely Moving Mice

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