APPW2025

Oranizers :Shin-ya Kawaguchi (Graduate School of Science, Kyoto University) and Haruyuki Kamiya (Graduate School of Medicine, Hokkaido University)

Neural circuits in the brain are highly sophisticated biological hardware enabling ultra-fast parallel computation of concurrent sensory-to-motor transformation with reference to their internal memories. For understanding mechanisms underlying fast and efficient computation in the nervous system, microscopic analysis of the structure and the function of synapses and axons, as functional elements of neuronal components, is essential. In this symposium, we aim to overview and search trends of subcellular neurobiology research elucidating unknown physiological functions of synapses and axons, by challenging experimental difficulties arising from the analysis of small structures. Functional analysis of organelles in axons using novel microscopy techniques, the mechanisms of action of novel cannabinoid receptors on the presynaptic terminals, co-transmission mechanisms of dual neurotransmitters from the presynaptic terminals, the possibility of local control of the propagation of axonal spike, will be introduced. Future directions for offering cutting-edge strategies for innovation in subcellular neurobiological research will be discussed.