APPW2025

Oranizers :Hiroyuki Konishi (Department of Functional Anatomy and Neuroscience, Nagoya University Graduate School of Medicine) and Jun Hatakeyama (Department of Brain Morphogenesis, Institute of Molecular Embryology and Genetics, Kumamoto University)

The cerebrospinal fluid (CSF) produced by the choroid plexus is thought to provide nutrients to the neurons and glial cells, as well as collect and clear waste products from these cells. The concept of CSF flow has been changed dramatically over the past decade by the discovery of the glymphatic system and dural lymphatic vessels. In addition, our understanding of the meninges, which surrounds CSF, has been changing from a physical structure that surrounds the brain to a functional structure that affects brain functions. In this symposium, we will discuss the involvements of cerebrospinal fluid and meninges in life events such as brain development, aging, and pathology, based on unpublished data from both morphological and molecular aspects. Although research on CSF and meninges is considered as a trend, especially in the past few years with many publications in top journals, Japanese researchers are very few. In addition, most non-specialists may not catch up with the concepts possibly because of their novelty. Research on CSF and meninges is timely and prospective, we hope to spread understanding in this conference.