APPW2025

Oranizers :Koh Nakayama (Dept. of Pharmacology, Sch. of Medicine, Asahikawa Medical University) and Shuhei Tomita (Dept of Pharmacology, Osaka Metropolitan University Graduate School of Medicine )

Hypoxic condition is formed in our body when oxygen demand exceeds its supply. It is found elsewhere in our body, and extreme hypoxic condition is formed in diseases such as cancer or ischemia. Our body induces hypoxic response under such conditions to prevent damages. However, hypoxic condition also promotes malignancy of cancers. Hypoxia-Inducible Factor, HIF is a central transcription factor which regulates hypoxic response, however, there are still unknown molecular mechanism regulating the adaptation process to hypoxia. Further, role of hypoxic response in pathophysiological events have also become clearer these days, whereas means to treat hypoxic diseases are still limited. In this symposium, experts in cancer, cardiology, neurons, and metabolism will gather and introduce their own specialties such as tumor model, knockout mice model or imaging. We aim to understand the hypoxic response system, and obtain new ideas for drugs targeting hypoxic responses.