APPW2025

Oranizers :Takahiro Nemoto (Nippon Medical School) and Shiro Tochitani (Suzuka University of Medical Science)

The Developmental Origins of Health and Disease (DOHaD) theory proposes that an unfavorable environment during the early developmental stage increases the risk of various noncommunicable diseases. In the epidemiological study of the Dutch famine, it was reported that not only the children whose mothers experienced famine during pregnancy had small body sizes and a higher incidence of noncommunicable diseases, but also their grandchildren had low birth weights. Thus, it raises concerns that the health of their descendants may be compromised. However, the mechanisms underlying the formation of disease risk by which the fetal environment and transgenerational disease susceptibility have still remained unclear. Therefore, in this symposium, we would like to understand morphologically, physiologically, and pharmacologically how an unfavorable environment during early development forms the risk of noncommunicable diseases and how it affects the next generation, and to discuss methodologies for interrupting intergenerational transmission to ensure a healthy future for our descendants.