APPW2025

Oranizers :Yoshiaki Suzuki (Department of Molecular and Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya City University) and Gerald Zamponi (Department of Clinical Neurosciences, Hotchkiss Brain Institute, Alberta Children's Hospital Research Institute, University of Calgary)

Ca2+ ions serve as a second messenger that is essential for life processes; however, excessive Ca2+ levels contribute to various diseases. In this symposium we will introduce (1) the mechanism of pain initiation via the Cav3.2-USP5 complex in DRG neurons and the development of therapeutic drugs targeting it (Zamponi), (2) TRPA1-mediated astrocytic Ca2+ signaling as an intrinsic protective response to vascular cognitive impairment (Shirakawa), (3) the role of RyR1 Ca2+-induced Ca2+ release (CICR) activity discovered from unique RyR1 mutant mice and its relationship to skeletal muscle diseases (Murayama), (4) the sex-specific mechanism of pulmonary arterial hypertension caused by calcium-sensing receptors discovered from comprehensive analysis (Yamamura), and (5) the mechanism by which Ca2+ channel molecular complexes contribute to vascular remodeling (Suzuki). This symposium is expected to share the achievements of the presenters in the field of Ca2+ signaling with an audience from a wide range of research fields, leading to the development of next-generation Ca2+ signaling research that is not limited to the organ being studied.