APPW2025

Oranizers :Makoto Tsuda (Kyushu University) and Hidemasa Furue (Hyogo Medical University)

Pain is an important sensation for sensing nociceptive stimuli from inside and outside the body and for generating and acquiring avoidance behavior from these stimuli. Our understanding of the mechanisms of the sensing of nociceptive stimuli has been greatly advanced by many previous studies on molecules expressed at nociceptors, especially TRPV1. On the other hand, it is increasingly recognized that sleep dysfunction, anxiety, and stress have a great impact on the pain system, expecting that the research on their regulation will lead to the discovery of new pain control mechanisms that cannot be found from conventional viewpoints. Furthermore, recent studies have shown that the pain system also critically contributes to the control of the function of peripheral organs, the immune system, and cancer cells, suggesting its unexpected broader roles. In this symposium, four speakers will show their latest findings regarding the pain control system and its link to systemic functions, deepen our understanding of new aspects of the pain system, and we will also discuss disease mechanisms and their potential for therapeutic applications.