Presentation Information
[1P-092]Transcriptome and genome mutation analysis of non-small cell lung cancer for elucidation of cell diversity in cancer microenvironment after EGFR-TKI treatment
*Miki Yamazaki1,2, Hiroko Matsunaga3, Masahito Hosokawa1,3, Koji Arikawa3, Naoko Suzuki3, Takuo Hayashi4, Haruko Takeyama1,2,3,5 (1. Department of Advanced Science and Engineering, Waseda University, 2. CBBD-OIL, AIST-Waseda University, 3. Research organization for Nano and Life Innovation, Waseda University , 4. Institute for Advanced Research of Biosystem Dynamics, Department of Human Pathology, Graduate School of Medicine, Juntendo University, 5. Waseda Research Institute for Science and Engineering, Waseda University)
Keywords:
Transcriptome,Mutation,Spatial analysis,Cancer microenvironment,EGFR-TKI
がん組織の薬剤応答を理解するには、投与後に変化するゲノム変異及び遺伝子発現を捉える必要がある。本研究では、分子標的薬投与後のヒト肺がん組織において、隣接する微小領域から細胞型の多様性を捉えた。