[2B-04] Development of novel higher-order structures based on the control of molecular assembly behavior associated with polyion complex formation using oligonucleotides | The 15th Symposium on Biorelevant Chemistry

The 15th Symposium on Biorelevant Chemistry

Sep 8 - Sep 10, 2021Held Online

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The 15th Symposium on Biorelevant Chemistry

Sep 8 - Sep 10, 2021Held Online

[2B-04]Development of novel higher-order structures based on the control of molecular assembly behavior associated with polyion complex formation using oligonucleotides

*Hiroshi Kamizawa¹, Tomoki Maruyama¹, Yiwei Liu¹, Teruki Nii^1,2, Kanjiro Miyata³, Takeshi Mori^1,2, Yoshiki Katayama^1,2,4, Akihiro Kishimura^1,2,4(1. Graduate School of Systems Life Sciences, Kyushu University, 2. Department of Applied Chemistry, Faculty of Engineering, Kyushu Univ., 3. Department of Materials Engineering, Graduate School of Engineering, The University of Tokyo., 4. International Research Center for Molecular Systems, Kyushu University)

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Keywords:

Polyion complexes,Self assembly,Oligonucleotides

ポリイオン同士を混合することで静電相互作用に基づきポリイオンコンプレックス (PIC) が形成される。特徴ある形状を持つポリイオンを用いる場合、その特徴を反映したPIC集合体を得ることができる。本研究では、剛直円筒状構造で平滑末端を有する二本鎖オリゴ核酸を用い、集合化挙動を制御できると考えられるポリイオンを同時に混合することで、オリゴ核酸を集積化した新規高次構造体を構築した。

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