The 17th Symposium on Biorelevant Chemistry
Sep 8 - Sep 10, 2023Tokyo University of Science
The 17th Symposium on Biorelevant Chemistry
Sep 8 - Sep 10, 2023Tokyo University of Science
[1OA-01]Photo-driven artificial metalloenzyme: Switching photochemical properties of a synthetic metal complex in a protein scaffold
*Yasunori Okamoto1, Shinichi Sato1,2, Takuya Mabuchi1,3(1. Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, 2. Graduate School of Life Sciences, Tohoku University, 3. Institute of Fluid Science, Tohoku University)
Keywords:
artificial metalloenzyme,photocatalysis,protein labeling
[Ru(bpy)2(dppz)]2+をriboflavin binding protein(RFBP)の内部空間に導入し、光駆動型人工金属酵素を構築した。[Ru(bpy)2(dppz)]2+単体では一電子移動反応、人工金属酵素ではエネルギー移動反応を優先的に進行させる。この反応タイプの切り替えをアミノ酸残基選択的なタンパク質のラベル化に適用した。