The 18th Symposium on Biorelevant Chemistry
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Session Details

Poster Session : 1P-01～1P-109

ポスター発表

Thu. Sep 12, 2024 1:20 PM - 3:00 PM JST
Thu. Sep 12, 2024 4:20 AM - 6:00 AM UTC
Poster Session Hall(Multi-purpose Hall)

[1P-01]Development of activity-based probe to elucidate the activity regulation and localization of 3CL protease in SARS-CoV-2 infected cells.

*Yuki Yamauchi1, Sho Konno2, Noriko Omura1, Narumi Yoshioka2, Alexandra Hingst3, Michael Gütschow3, Christa E Müller3, Akihiro Taguchi2, Atsuhiko Taniguchi2, Atsushi Kawaguchi4, Yoshio Hayashi2,5 (1. Graduate School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 2. School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 3. Pharmaceutical Institute, Pharmaceutical & Medicinal Chemistry, University of Bonn, 4. Institute of Medicine, Transborder Medical Research Center, University of Tsukuba, 5. School of Life Sciences, Tokyo University of Pharmacy and Life Sciences)

[1P-02]Protein engineering of chemigenetic Ca2+ indicator based on eDHFR tag

*Kenryo Sakoi1, Takuya Terai1, Robert Earl Campbell1 (1. Graduate School of Science, The University of Tokyo)

[1P-03]Detection and separation of disulfide-coupled folding intermediates of mid-size proteins

*Nana Sakata1, Yuri Murakami1, Orika Ashida1, Kyona Hiroshima1, Mitsuhiro Miyazawa2, Shigeru Shimamoto1, Yuji Hidaka1 (1. Graduate School of Science and Engineering Research, Kindai University, 2. PrevenTec Inc.)

[1P-04]All-atom molecular dynamics simulations of the mechanical properties of the domains of the fiber protein AtaA

*Jun Sasahara1, Keita Hemmi1, Shogo Yoshimoto1, Katsutoshi Hori1 (1. Graduate School of Engineering, Nagoya University)

[1P-05]Abiotic Photo-driven Radical Acylations Catalyzed by FAD/ThDP-dependent Enzymes

*Yuto Adachi1, Shuto Fujisawa1, Shunsuke Kato1, Takashi Hayashi1 (1. Graduate School of Engineering, Osaka University)

[1P-06]Development of Dicarboxylic Acid-Based Decoy Molecules to Promote Oxidation of Non-Native Substrates by Cytochrome P450BM3

*Megumi Ishigami1, Shinya Ariyasu1, Chie Kasai1, Yuichiro Aiba1, Hiroshi Sugimoto2, Osami Shoji1 (1. Graduate School of Science, Nagoya University, 2. SPring-8, RIKEN)

[1P-07]Development of Fluorescent Probes for Detection of Protein-protein Interaction Using a Reversible Labeling System

*Jiatong Li1, Masafumi Minoshima1, Kazuya Kikuchi1,2 (1. Graduate School of Engineering, Osaka University, 2. Immunology Frontier Research Center, Osaka University)

[1P-08]Establishment of a High-Purity Purification Method for a Dimeric Cancer-Related Enzyme Composed of one Wild-Type and one Single-Residue Mutant Subunit

*Natsumi Matsumoto1, Eika Kan1, Oka Tomomasa1, Tomoaki Ishiba2, Kazasi Kato2, Ayaka Harada2, Kenji Iwasaki2,3 (1. Chemistry Program, Graduate School of Pure and Applied Sciences, University of Tsukuba, 2. Tsukuba Advanced Research Alliance Center, University of Tsukuba, 3. Center for Quantum and information Life Sciences, University of Tsukuba)

[1P-09]Development of a FRET-based viscosity-sensitive fluorescence probe for measuring intracellular local viscosity

*Shuto Kasai1, Eita Sasaki1,2, Marina Shimba2, Takahiro Mori3, Ikuro Abe3, Kenjiro Hanaoka1,2 (1. Graduate School of Pharmaceutical Sciences, Keio University, 2. Faculty of Pharmacy, Keio University, 3. Graduate School of Pharmaceutical Sciences, The University of Tokyo)

[1P-10]Generation of the smallest Monobody-tag for fluorescence imaging

*Tomoki Miyazaki1, Shun Umemoto2, Masaaki Tsuduki2, Natsumi Fukaya1, Chung Nguyen Kim2, Tatsuyuki Yoshii1, Masaru Yoshikawa1, Tomoshige Fujino2, Gosuke Hayashi2, Hiroshi Murakami2,3, Shinya Tsukiji1 (1. Graduate School of Engineering, Nagoya Institute of Technology, 2. Graduate School of Engineering, Nagoya University, 3. Institute of Nano-Life-Systems, Institute of Innovation for Future Society, Nagoya University)

[1P-11]Chemogenetic activity manipulation of epidermal growth factor receptor (EGFR) using SLIPT-PM

*Shuya Ohira1, Kai Tahara1, Masaru Yoshikawa1, Shinya Tsukiji1 (1. Graduate School of Engineering, Nagoya Institute of Technology)

[1P-12]Modification of DNA-binding protein Rep for post-translational modification

*Mizuki Murayama1, Kei Nishida1, Eiry Kobatake1, Masayasu Mie1 (1. School of Life Science and Technology, Tokyo Institute of Technology)

[1P-13]Refolding Large Denatured Proteins by 2D Assembled GroEL Immobilized on Silica Surface

*Tonmoy Ray1, Takayuki Miki1, Hideki Taguchi2, Tatsuya Niwa2, Takuzo Aida1,3 (1. The University of Tokyo, 2. Tokyo Institute of Technology, Suzukakedai , 3. Center for Emmergent Matter Science, RIKEN)

[1P-14]Promotion of oxidative folding by a thiol compound bearing protein recognition units.

*Koki Suzuki1, Ryoya Nojiri1, Tomohide Saio2, Masaki Okumura3, Takahiro Muraoka1,4 (1. Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2. Institute of Advanced Medical Sciences, Tokushima University, 3. Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, 4. Kanagawa Institute of Industrial Science and Technology)

[1P-15]Binding properties and inhibitory effects on cancer invasion of anti-clic1 monoclonal antibody

*Kazuki Imai1,2, Samrat Mukherjee2,3, Masumi Iijima4, Ayana Yamagishi1,2,3, Chikashi Nakamura1,2,3 (1. Faculty of Engineering, Tokyo University of Agriculture and Technology, 2. Cellular and Molecular Biotechnology Research Institute, National Institute of Advanced Industrial and Science Technology, 3. Graduate School of Engineering, Tokyo University of Agriculture and Technology, 4. Faculty of Applied Biosciences, Tokyo University of Agriculture)

[1P-16]Development of functional DNA-encoded library based on in-protein synthesis of photopharmacological ligands using bioorthogonal chemistry

*Yuka Segawa1, Souta Fujiwara2, Kazuya Matsuo3, Tomonori Waku3, Akio Kobori3 (1. Graduate School of Science and Technology, Kyoto Institute of Technology, 2. School of Science and Technology, Kyoto Institute of Technology, 3. Faculty of Molecular Chemistry and Engineering, Kyoto Institute of Technology)

[1P-17]Development of oxidative protein folding promotors functioning under high concentrations and understanding of their mechanisms

*Mai Kitamura1, Takahiro Muraoka1,2 (1. Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2. KISTEC)

[1P-18]Development of covalent monobody-tag based on proximity-induced reactivity

*CHUNG KIM NGUYEN1, Tomoki MIYAZAKI3, Shinya TSUKIJI3, Tomoshige FUJINO1, Gosuke HAYASHI1, Hiroshi MURAKAMI1,2 (1. Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University, 2. Institute of Nano-Life-Systems, Institutes of Innovation for Future Society, Nagoya University, 3. Department of Life Science and Applied Chemistry, Graduate School of Engineering, Nagoya Institute of Technology)

[1P-19]Methylation of a fiber protein on the bacterial cell surface

*Shori Inoue1, Shogo Yoshimoto1, Katsutoshi Hori1 (1. Department of Biomolecular Engineering, Graduate School of Engineering, Nagoya University)

[1P-20]Controlling the motion of pH-responsive piston protein assemblies by external stimuli

*Souta Masumura1, Koki Date1, Thuc Toan Pham1, Xin Li1, Kosuke Kikuchi1, Takafumi Ueno1 (1. School of Life Science and Technology , Tokyo Institute of Technology)

[1P-21]Development of selective small-molecule inhibitors for the Jasmonate-related master transcription factor MYC

*Ruiqi Liu1, Koshiki Mino2, Akiko Idei 2, Minoru Yoshida2, Minoru Ueda1,3, Yousuke Takaoka1 (1. Graduate School of Science, Tohoku University, 2. RIKEN Center for Sustainable Resource Science, 3. Graduate School of Life Sciences, Tohoku University)

[1P-22]Control of GLUT4 Dynamics Using Synthetic Molecules

*Takuma Mitarai1, Junya Adachi1, Kumpei Yano2, Yoshiyuki Manabe2, Yuichiro Hori1 (1. Graduate School of Science, Kyushu University, 2. Graduate School of Science, Osaka University)

[1P-23]Development of an activatable reporter enzyme which responds to antigen binding

*Rikuki Kiji1, Ryosuke Kojima2, Ziyi Wang2, Ryo Tachibana1, Naoki Seike1, Yasuteru Urano1,2 (1. Graduate School of Pharmaceutical Sciences, The University of Tokyo, 2. Graduate School of Medicine, The University of Tokyo)

[1P-24]Phenotypic Inhibitor Screening based on metabolic activity of fatty acid oxidation

*Ruikang Yin1, Kzuya Inoue, Saki Inoue1, Xiwen Xiao1, shyohei Uchinomiya1, Akio Ojida1 (1. Pharmaceutical science, Kyushu University)

[1P-25]Development of a stoichiometric and irreversible DNA-Protein linking tool for the convenient fabrication of biosensing elements

Erika Komiya1, *Mizuki Nakashima2, Daimei Miura1, Kaori Tsukakoshi1, Wakako Tsugawa1, Koji Sode3, Ikebukuro Kazunori1, Ryutaro Asano1 (1. Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2. Faculty of Engineering, Tokyo University of Agriculture and Technology, 3. The University of North Carolina at Chapel Hill and North Carolina State University)

[1P-26]Proximity-based site-specific modification of antibody fragment by novel fusion proteins of cross-linking enzyme

*Koki Murozono1, Riko Nishioka1, Kazuki Uchida1, Yoshiro Kawaguchi1, Michio Kimura1, Noriho Kamiya1,2 (1. Graduate School of Engineering, Kyushu University, 2. Center for Future Chemistry, Kyushu University)

[1P-27]In vitro directed evolution of A2A receptor using Ribosome Display

*Genki Fukasawa1, Yuma Matsuoka2, Tomohiro Doura2, Shigeki Kiyonaka2, Tomoaki Matsuura3 (1. School of Life Science and Technology, Tokyo Institute of Technology, 2. Department of Biomolecular Chemistry, Nagoya University, 3. Earth Life Science Institute, Tokyo Institute of Technology)

[1P-28]Functional analysis of membrane receptors expressed on magnetosome by modifying membrane lipid compositions

*Mayuka Kobayashi1, Ryoto Tomoe1, Sayaka Tayama1, Kazushi Fujimoto1, Tsuyoshi Tanka1, Tomoko Yoshino1 (1. Graduatet School of Engineering, Tokyo University of Agriculture and technology)

[1P-29]Photo-crosslinking heterotypic polyubiquitin probes for exploration of ubiquitin functions encoded on the branch structure

*Taiki Uno1, Usano Toyoda1, Takafumi Furuhata1, Takuya Tomita2, Yusuke Sato3,4, Kei Okatsu5, Shuya Fukai5, Yasushi Saeki2, Akimitsu Okamoto1 (1. Graduate school of Engineering, The University of Tokyo, 2. The Institute of Medical Science, The University of Tokyo, 3. Graduate School of Engineering, Tottori University, 4. GSC center, Tottori University, 5. Gradaute School of Engineering, Kyoto University)

[1P-30]Structure and function of a novel hexanuclear iron-sulfur cluster in the protein GciS from Megavirinae Giant Virus.

*Hodaka Tani1, Masaki Nojiri1 (1. Graduate School of Science, Osaka University)

[1P-31]Development of a method for obtaining Cas9 mutants capable of inducing homologous recombination

*Daisuke Matsumoto1,2, Komari Kubota2, Shahram Ahmadi1, Kiyomi Nigorikawa1,2, Wataru Nomura1,2 (1. Graduate School of Biomedical and Health Sciences, Hiroshima University, 2. School of Pharmaceutical Sciences)

[1P-32]Design of Cyborg Proteins by Loop Region Replacement With Oligo(ethylene glycol)

*Wijak Yospanya1,2, Akari Matsumura3, Yukihiro Imasato1, Tomoyuki Itou4, Yusuke Aoki1, Hikaru Nakazawa4, Takashi Matsui3, Takeshi Yokoyama3, Mihoko Ui5, Mitsuo Umetsu4, Satoru Nagatoishi6,7, Kouhei Tsumoto6,7,8, Yoshikazu Tanaka3, Kazushi Kinbara1,9 (1. School of Life Science and Technology, Tokyo Institute of Technology, 2. AIMR, Tohoku University, 3. Graduate School of Life Science, Tohoku University, 4. Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University, 5. IMRAM, Tohoku University, 6. Medical Device Development and Regulation Research Center, School of Engineering, The University of Tokyo, 7. Department of Bioengineering, Graduate School of Engineering, The University of Tokyo, 8. Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, 9. Living Systems Materialogy Research Group, IRFI, Tokyo Institute of Technology)

[1P-33]Assembly design of two-component cytoskeleton-like protein tubes.

*Masahiro Noji1,2,3, Yukihiko Sugita4,5,6, Yosuke Yamazaki7,8, Makito Miyazaki6,7,8,9,10, Yuta Suzuki3,6,9 (1. Research Fellow of JSPS, 2. Graduate School of Human and Environmental Studies, Kyoto University, 3. Institute for Integrated Cell-Material Sciences, Kyoto University, 4. Institute for Life and Medical Sciences, Kyoto University, 5. Graduate School of Biostudies, Kyoto University, 6. Hakubi Project, Kyoto University, 7. Graduate School of Science, Kyoto University, 8. RIKEN Center for Biosystems Dynamics Research, 9. PRESTO Researcher, JST, 10. Graduate School of Medicine, Science and Technology, Shinshu University)

[1P-34]Development of EpiTAC to degrade epigenetics related proteins

*Soshu Yasuda1, Kunihiko Morihiro1, Akimitsu Okamoto1 (1. Department of chemistry and biotechnology, school of engineering)

[1P-35]A ClpP-activating mechanism of the antibiotic acyldepsipeptide 1 (ADEP1) and ADEP1 structure-activity relationships

*Fumihiro Ishikawa1, Kanji Takahashi2, Naoto Shobayashi1, Syusuke Akinaga1, Michio Homma3, Takayuki Uchihashi2, Genzoh Tanabe1 (1. Faculty of Pharmacy, Kindai University, 2. Department of Physics, 3. Graduate School of Engineering)

[1P-36]Generation of nitrene under physiological conditions for protein modification

*Haruki Toyoshima1, Akitomo Kasahara2, Kenzo Yamatsugu2 (1. Faculty of Pharmaceutical Sciences, Chiba University, 2. Graduate School of Pharmaceutical Sciences, Chiba University)

[1P-37]Pseudo-Luciferase Activity of the SARS-CoV-2 Spike Protein for Cypridina Luciferin

*Ryo Nishihara1,2, Hisham M Dokainish3,4, Yoshiki Kihara1,5, Yuji Sugita4,6,7, Ryoji Kurita1,5 (1. Health and Medical Research Institute, National Institute of Advanced Industrial Science and Technology, 2. PRESTO, Japan Science and Technology Agency (JST), 3. Faculty of Pharmaceutical Sciences, Hokkaido University, 4. Theoretical Molecular Science Laboratory, RIKEN Cluster for Pioneering Research, 5. Faculty of Pure and Applied Sciences, University of Tsukuba, 6. Laboratory for Biomolecular Function Simulation, RIKEN Center for Biosystems Dynamics Research, 7. Computational Biophysics Research Team, RIKEN Center for Computational Science)

[1P-38]Development of an artificial nucleic acid-based triplex capable of dimerization on artificial cell membranes

*Kaifu Liu1, Keiji Murayama1, Hiroyoki Asanuma1 (1. Graduate School of Engineering, Nagoya University)

[1P-39]Synthesis of SNA involving photocrosslinkable novel modified base and photo-regulation of SNA/RNA duplex

*Ayaka Ikeda1, Fuminori Sato1, Keiji Murayama1, Hiroyuki Asanuma1 (1. Graduate School of Engineering, Nagoya University)

[1P-40]Enzymatic metabolic reactions compartmentalized in liposome with a skeletal DNA nanostructure

*Futa Komatsubara1,2, Eiji Nakata1, Peng Lin1, Takashi Morii1,3 (1. Institute of Advanced Energy, Kyoto University, 2. Graduate School of Energy Science, Kyoto University, 3. Faculty of Health Science, Kyoto Koka Women's University)

[1P-41]Chemically-synthesized DNA barcodes to enable expansion of reaction conditions and increase in synthetic cycles ensuring high purity and high yield in DNA-Encoded Library

*Masumi Shirakawa1, Ryosuke Ueki1, Jumpei Morimoto1, Shinsuke Sando1 (1. Graduate School of Engineering, The University of Tokyo)

[1P-42]Liquid-liquid phase separation of G-quadruplexes with structured loop region

*Naoki Kosaka1, Minori Nakata1, Mitsuki Tsuruta1, Keiko Kawauchi1, Daisuke Miyoshi1 (1. Konan University)

[1P-43]Control of DNA assembly using two pairs of short dsDNA as building blocks

*Tetsunao Makino1, Makiko Tanaka1 (1. Graduate Department of Engineering Science, The University of Electro-Communications)

[1P-44]Development of G4-PROTAC ligands for degradation of G-quadruplex binding proteins

*Rena Nohara1, Yuuma Tanaya1, Kazuo Nagasawa1, Tera Masayuki1 (1. Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology)

[1P-45]Detection of miRNAs using 19F-labeled oligodeoxynucleotides by 19F NMR

*Yuki Hida1, Tatsuya Nishihara1, Kazuhito Tanabe1 (1. Graduate school of Science and Engineering, Aoyama Gakuin University)

[1P-46]Investigation of solution conditions for DNA detection by potentiometry

*Masanori Igari1, Hiroyuki Furusawa1,2 (1. Graduate School of Organic Materials Science, Yamagata University, 2. IPGE, Yamagata University)

[1P-47]DNA droplet formation ability and ssDNA-binding property of an azolato-bridged dinuclear platinum complex

*Takuma Yamada1, Ryu Tashiro2, Masako Uemura1,2, Katsuhiko Minoura3, Seiji Komeda1,2 (1. Graduate School of Pharmaceutical Sciences, Suzuka University of Medical Science, 2. Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, 3. Faculty of Pharmacy, Osaka Medical and Pharmaceutical University)

[1P-48]Analysis of RNA editing substrate recognition characteristics of ADAR2 using artificial substrate RNA

*Naoki Shimazu1, Shun Shimauchi1, Yuki Ogata1, Masatora Fukuda1,2 (1. Graduate School of Science, Fukuoka University , 2. Department of Chemistry, Faculty of Science, Fukuoka University)

[1P-49]Development of artificial DNA composed of alkynyl C-nucleotides that mimics the base pair size of natural A/T and G/C

*Komichi Yamamoto1, Junya Chiba1, Yuki Ohishi1, Masahiko Inouye1 (1. Graduate School of Pharmaceutical Sciences, University of Toyama)

[1P-50]Development of split aptamers for recognition and sensing of RNase H

*Yuuki Narita1 (1. Graduate School of Science and Technology, Kyoto Institute of Technology)

[1P-51]Transcription activity profiling at single-cell resolution via dual metabolic labeling for RNA sequencing

*Ryo Ryo Baba1,2, Fumiko Kawasaki1, Jumpei Morimoto3, Shinsuke Sando3, Yukihide Tomari1 (1. IQB, University of Tokyo, 2. Graduate School of Frontier Sciences, University of Tokyo, 3. Department of Chemistry & Biotechnology, Department of Bioengineering, School of Engineering, University of Tokyo)

[1P-52]Enhancement of Haploinsufficiency-related Gene Expression via RNA hacking Targeting 3'UTR

*Yua Itsuki1, Yousuke Katsuda1,2, Sato Shin-ich1,2, Yusuke Kitamura1, Ihara Toshihiro1 (1. Faculty of Advance Science and Technology, Kumamoto University, 2. StapleBio Inc.)

[1P-53]Controlling slip phenomena in DNA Polymerase by applying RNA hacking technology

*Miko Kato1, Yousuke Katsuda1,2, Yusuke Kitamura1, Shin-ichi Sato1,2, Toshihiro Ihara1 (1. Faculty of Advance Science and Technology, Kumamoto University, 2. StapleBio inc.)

[1P-54]Evaluation of helical amplification system of SNA tethering fluorescent dyes

*Itsumi Sugiyama1, Hiroyuki Asanuma1, Hiromu Kashida1 (1. Graduate School of Engineering, Nagoya University)

[1P-55]Eukaryotic Cell-Free Riboswitches based on Highly Modular and Efficient Self-Cleavage Aptazymes

*Masahiro Fujikawa1, Kazuki Onishi1, Hajime Takahashi1, Atsushi Ogawa1 (1. Proteo-Science Center, Ehime University)

[1P-56]Construction of eukaryotic riboswitches that regulate IRES-mediated translation through a kinetic trapping mechanism

*Hajime Takahashi1, Masahiro Fujikawa1, Atsushi Ogawa1 (1. Proteo-Science Center, Ehime University)

[1P-57]Metal-mediated Control of DNA Nanotube Assembly based on Destabilization of Hydroxyuracil–Adenine Base Pairs

*Yusuke Takezawa1, Yuto Onishi1, Keita Mori1, Mitsuhiko Shionoya1,2 (1. Graduate School of Science, The University of Tokyo, 2. Research Institute for Science and Technology, Tokyo University of Science)

[1P-58]Novel sequencing method of peptide nucleic acid bearing artificial bases

*Kazuma Inagaki1, Yuichiro Aiba2, Osami Shoji2, Hiroyuki Asanuma1, Hiromu Kashida1 (1. Graduate School of Engineering, Nagoya University, 2. Graduate School of Science, Nagoya University)

[1P-59]Sequence analysis of acyclic artificial nucleic acid SNA by utilizing duplex formation

*Nozomi Hibino1, Hiroyuki Asanuma1, Hiromu Kashida1 (1. Graduate School of Engineering, Nagoya Univ.)

[1P-60]RNA encapsulation and photo-responsive release in caged coacervates

*Akinari Bando1, Kazunori Watanabe1, Mari Takahara1, Seiichi Fujiwara1, Yuuki Kanazaki2, Mizuki Kitamatsu2, Takashi Ohtsuki1 (1. Okayama University, 2. Kindai University)

[1P-61]Easy-handling detection of lead ions in the environment using lead ion-binding peptide-immobilized beads

*Shuhei Yoshida1, Koki Yoshida1, Takaaki Tsuruoka1, Kenji Usui1 (1. Graduate school of Frontiers of Innovative Research in Science and Technology (FIRST), Konan University)

[1P-62]NMR analysis of dimeric structures of amyloid β hydrophobic fragments by confinement in a self-assembled spherical coordination cage

*Yuta Onodera1, Takahiro Nakama1, Maho Yagi2, Daishi Fujita3, Koichi Kato2, Makoto Fujita1,2,4 (1. Graduate School of Engineering, The University of Tokyo, 2. Institute for Molecular Science, 3. iCeMS, Kyoto University, 4. Institutes for Advanced Study, The University of Tokyo)

[1P-63]Development of doubly-crosslinked peptides with improved proteolytic resistance and intracellular uptake

*Tetsuya Yasukagawa1, Junya Chiba1, Yuki Ohishi1, Satoru Yokoyama1, Yue Zhou1, Masahiko Inouye1 (1. Graduate School of Pharmaceutical Sciences, Univercity of Toyama)

[1P-64]Rational Construction of a Macrocyclic Hexadecapeptide with D-Amino Acids

*Hirotake Teruoka1, Michito Yoshizawa1, Tomohisa Sawada1,2 (1. Lab. for Chem. & Life Sci., Tokyo Tech, 2. JST-PRESTO)

[1P-65]Methods to reduce cytotoxicity caused by oligoarginine conjugation

*Kazuma Arakawa1, Maiko Kato1, Yasumichi Inoue1, Hidetoshi Hayashi1, Yosuke Hisamatsu1, Naoki Umezawa1 (1. Graduate school of Pharmaceutical Sciences, Nagoya City University)

[1P-66]Osmotic pressure-responsice droplet formation of de novo YK peptide-fused sfGFP in living cells

*Masatoshi Shimizu1, Takuzo Aida1, Takayuki Miki1 (1. The University of Tokyo)

[1P-67]Efficient Synthesis of Peptide Thioesters via Introduction of Substituents into Amino-acids and Evaluation of Thioester Formation Mechanism

*Genki Nakamura1, Koki Nakatsu1, Gosuke Hayashi1, Hiroshi Murakami1,2 (1. Graduate School of Engineering, Nagoya University, 2. Institute of Nano-Life-Systems, Nagoya University)

[1P-68]Selection of peptides that bind to target proteins using an engineered split intein

*Kana Nobusawa1, Yutaro Watanabe1, Tsuyoshi Takahashi1 (1. Gunma University)

[1P-69]Selection of proteins that bind to a peptide sequence using an engineered split intein

*Momoka Shimizu1, Kana Nobusawa1, Tsuyoshi Takahashi1 (1. Graduate School of Science and Technology, Gunma University)

[1P-70]Development of a luminescent probe for detecting the activity of the deglycosylating enzyme ENGase using split intein and luciferase

*Midori Aikyo1, Satoshi Takahashi2, Nozomi Ishii2, Ichiro Matsuo2, Yukiko Yoshida3, Tadashi Suzuki4, Tsuyoshi Takahashi2 (1. Department of Science and Technology, Gunma University, 2. Graduate School of Science and Technology, Gunma University, 3. Tokyo Metropolitan Institute of Medical Science, 4. RIKEN)

[1P-71]Construction of Nanopore peputide library and Analysis Methods for Nanopore Formation

*Moe Kobayashi1, Takuto Kariya1, Fumihiro Kayamori1, Peng Zugui2, Izuru Kawamura3, Ryuji Kawano2, Kenji Usui1 (1. Innovative Research and Technology (FIRST), Konan University, 2. Department of Biotechnology, Tokyo University of Agriculture and Technology, 3. Graduate School of Engineering Science, Yokohama National University)

[1P-72]Modification of gold nanorods with peptides containing a cell recognition site and evaluation of anti-cancer drug loading performance by the hydrophobic environment

*Conoha Yamaoka1, Takahito Imai1, Masahiro Asano1, Ki-nya Tomizaki1 (1. Ryukoku University)

[1P-73]Photothermal Effects of Gold Nanorods Modified with Hepatocellular Carcinoma Targeting Peptides

*Shoya Fujimoto1, Takahito Imai1, Masahiro Asano1, Masayuki Yamasaki1, Kin-ya Tomizaki1 (1. Ryukoku University)

[1P-74]Chemoenzymatic synthesis of resilin-like polypeptides by dityrosine crosslinking

*Kayo Terada1, Shogo Takemura1, Yui Tsuji1, Kousuke Tsuchiya2, Keiji Numata1,3 (1. Grad. Sch. of Eng., Kyoto Univ., 2. Grad. Sch. of Eng., Univ. of Tokyo, 3. RIKEN)

[1P-75]Synthesis and characterization of cancer selective peptides using mitochondria transfer signal peptide derivative.

*Soshin Saita1, Masayuki Yamasaki1, Kin-ya Tomizaki1 (1. Ryukoku University)

[1P-76]Assessment of antimicrobial peptide action on lipid bilayers by electrochemiluminescence

*Ibuki Takahashi1, Hiroya Abe2,1, Kaoru Hiramoto3, Kosuke Ino1, Ayumi Hirano2, Hitoshi Shiku1 (1. Graduate School of Engineering, Tohoku University, 2. Frontier Research Institute for Interdisciplinary Sciences Tohoku University, 3. Research Institute of Electrical Communication)

[1P-77]Photocatalytic hydrogen evolution system using red blood cell ghosts for catalytic reactors

*Taiga Sakamoto1, Tomomi Koshiyama1 (1. Graduate School of Life Sciences, Ritsumeikan University)

[1P-78]Enhancing Cell Aggregation and Migration via Double-Click Crosslinking with Azide-Modified Hyaluronic Acid

*Fumiya Sato1, Hernandez Paniagua Liliana Alejandra1, Hitoshi Takemae2, Natsuko Inagaki3, Taichi Ito3, Masayuki Tera1 (1. Graduate School of Engineering, Tokyo University of Agriculture and Technology, 2. Graduate School of Agriculture, Tokyo University of Agriculture and Technology, 3. Graduate School of Engineering, The University of Tokyo)

[1P-79]Development of nanostructured lipid carrier for 19F NMR probe

*Shiho Sugiura1, Tomoya Yamamoto1,2, Kazuya Kikuchi1,2 (1. Graduate school of Engineering, Osaka University, 2. Immunology Frontier Research Center, Osaka University)

[1P-80]Research on the application of photosensitizers that photocleavage DNA in an oxygen-independent way

*Yuri Shokaku1, Tomohiko Yamazaki2, Kohsaku Kawakami2, Atsuya Momotake1 (1. Degree Programs in Pure and Applied Sciences, Graduate School of Science and Technology, University of Tsukuba, 2. Research Center for Macromolecules and Biomaterials, NIMS)

[1P-81]Surface charge-controlled antigenic protein-modified peptide assemblies and their application to vaccine adjuvants

*Yuki Nabae1, Ayato Higuchi1, Rie Wakabayashi1, Noriho Kamiya1,2, Masahiro Goto1,2 (1. Graduate School of Engineering, Kyushu University, 2. Center for Future Chemistry, Kyushu University)

[1P-82]Intracellular Delivery of mRNA with a Chemical and Physical Stimuli-Responsive Zn(II)-Dipicolylamine-Attached Polythiophene

*Akira Matsumoto1, Yui Sasaki1,2,3, Kazuhiko Tsuchiya1, Tsuyoshi Minami1 (1. Institute of Industrial Science, The University of Tokyo, 2. Research Center for Advanced Science and Technology, The University of Tokyo, 3. JST PRESTO)

[1P-83]Control of Plasma Membrane Potential by Photo-Induced Charge Separation Molecule-Loaded Nanodiscs.

*Hayato Takagi1, Rion Yamada2, Eri Sakuda2, Tomohiro Numata3, Tatsuya Murakami1,4 (1. Graduate School of Engineering, Toyama Prefectural University, 2. Graduate School of Engineering, Nagasaki University , 3. Graduate School of Medicine, Akita University, 4. iCeMS, Kyoto University)

[1P-84]Analysis of localization of nectriatide derivative, a potentiator of amphotericin B, in Saccharomyces cerevisiae using Raman microspectroscopy

*Ryosuke Miyake1, Masahiro Ando2,4, Keisuke Kobayashi3, Hiroshi Tomoda3, Taichi Ohshiro3, Haruko Takeyama1,2,4,5 (1. Graduate school of Advanced Science and Engineering, Waseda University, 2. Res. Org. Nano Life Innov., Waseda Univ., 3. Grad. Sch. Pharm. Sci., Kitasato Univ., 4. CBBD-OIL, AIST-Waseda Univ., 5. Inst. Adv. Res. Biosyst. Dyn., Waseda Res. Inst. Sci. Eng., Waseda Univ.)

[1P-85]Development of a simple and rapid preparation of Zn-chlorophyll derivatives

*Yasuho Takashima1, China Okamoto2, Atsuya Momotake2, Masataka Nakasato3, Yasuhiko Yamamoto2, Masami Kobayashi1 (1. Department of Materials Science, University of Tsukuba, 2. Department of Chemistry, University of Tsukuba, 3. Chlorophyll Research Institute)

[1P-86]Three-dimensional imaging analysis of platelet-adherent
circulating tumor cells

*Takeshi Yoshioka1, Sayaka Goto1, Takatsugu Okegawa2, Mayumi Deki2, Tsuyoshi Tanaka1, Tomoko Yoshino1 (1. Faculty of Engineering, Tokyo University of Agriculture and Technology Graduate School , 2. Faculty of Medicine, Kyorin University)

[1P-87]Preparation of the photosensitizer dye-immobilized glass plate: effect on the cultured mesenchymal stem cell

*Masayuki Hara1, Hideki Mori1 (1. Dept. Biol. Chem. Grad. Sch. Sci. Osaka Metropolitan University)

[1P-88]Enhancement effect of alternating current electric fields on bacterial swarming motility

*Yukiya Kobayashi1, Yuki Ayusawa1, Mizuki Yamaguchi1, Sumihiro Koyama2, Yoichi Ishikawa2, Eri Nasuno1, Norihiro Kato1 (1. Graduate School of Regional Development and Creativity, Utsunomiya University, 2. ABLE Corporation)

[1P-89]Development of electron-transfer-triggered visible-light-responsive photolabile protecting groups

*Naoya Ieda1,2, Akira Nakamura2, Miyu Tachi2, Natsumi Tomita2, Yuji Hotta3, Kei Ohkubo4, Mitsuyasu Kawaguchi2, Hidehiko Nakagawa2 (1. Graduate School of Pharmaceutical Sciences, Hokkaido University, 2. Graduate School of Pharmaceutical Sciences, Nagoya City University, 3. Graduate School of Medical Sciences, Nagoya City University, 4. Institute for Open and Transdisciplinary Research Initiatives & Institute for Advanced Co-Creation Studies, Osaka University)

[1P-90]Development of bispecific antibodies to reduce side effects and induce tumor-specific activation

Yuki KATO1, *Takeru KANAZU1, Izumi KUMAGAI1, Ryutaro ASANO1 (1. Department of Biotechnology and Life Science, Graduate School of Engineering, Tokyo University of Agriculture and Technology)

[1P-91]Development of a Host Molecule that Captures Isoprenoids by Coordination Bonds

*Kohtaro Sugawara1, Takashi Nakamura2 (1. Degree Programs in Pure and Applied Sciences, University of Tsukuba, 2. Institute of Pure and Applied Sciences, University of Tsukuba)

[1P-92]Development of fluorescence probes for sensing protein synthesis in mitochondria

*Shun Sumitani1, Eita Sasaki1, Hisashi Ohno1, Kenjiro Hanaoka1 (1. Graduate School of Pharmaceutical Sciences, Keio University)

[1P-93]Roles of Hydrogen Bonds and Water Molecules in the Molecular Recognition by a Phosphate Receptor

*Hayato Takayanagi1, Masaki Nakahata2, Yoshiki Ishii3, Go Watanabe3,4, Takashi Nakamura5 (1. Degree Programs in Pure and Applied Sciences, University of Tsukuba, 2. Graduate School of Science, Osaka University, 3. School of Frontier Engineering, Kitasato University, 4. Kanagawa Institute of Industrial Science and Technology, 5. Institute of Pure and Applied Sciences, University of Tsukuba)

[1P-94]Construction and physical property analysis of knitted metal–peptide nanosheets

*Ryuta Hobo1, Michito Yoshizawa1, Tomohisa Sawada1,2 (1. Lab. for Chem. & Life Sci., Tokyo Tech, 2. JST-PRESTO)

[1P-95]Dual-Responsive Near-Infrared Turn-on Fluorescent Probe for Cancer Stem Cell-Specific Visualization

*Koki Miki1, Koji Miki1, Masahiro Oe1, Kanae Suzuki1, Huiying Mu1, Hiroshi Yukawa2, Kouichi Ohe1 (1. Graduate School of Engineering, Kyoto University, 2. Institutes of Innovation for Future Society, Nagoya University)

[1P-96]Fluorogenic probes based on meso-vinyl-BODIPY for discrimination of different thiols

*Sayoko Yamamoto1, Huiying Mu1, Koji Miki1, Kouichi Ohe1 (1. Faculty of Engineering, Kyoto University)

[1P-97]In situ Fe(II) probe synthesis by intramolecular imine trap strategy for precise labile iron detection

*Kanta Kawai1, Mieko Tsuji1, Tasuku Hirayama1 (1. Gifu pharmaceutical university)

[1P-98]Evaluation of fragile erythrocytes by chemiluminescence from the forensic luminol reaction

*Misato Nakata1, Nobuhiro Yukawa2, Tsutomu Shiragami1 (1. Faculty of Engineering, University of Miyazaki , 2. Faculty of Medicine, University of Miyazaki)

[1P-99]Cancer diagnosis based on in vivo multiplexed analysis of aminopeptidase activities using hyperpolarized MRI molecular probes

*Hiroyuki Yatabe1, Yutaro Saito1, Yoichi Takakusagi2,3, Keita Saito2, Kazutoshi Yamamoto4, Murali Krishna4, Shinsuke Sando1 (1. The University of Tokyo, 2. National Institutes for Quantum Science and Technology, 3. Graduate School of Science, Chiba University, 4. National Institutes of Health, USA)

[1P-100]Super-resolution Infrared Absorption Spectroscopic Imaging of Amyloid Fibrils for Elucidating Protein Aggregation Processes

*Yuta Hamada1, Toshiaki Hirose1, Tatsuo Dougakiuchi2, Gen Takebe2, Yoichi Kawada2, Yoshimasa Kawata1, Atsushi Ono1 (1. Graduate School of Engineering, Shizuoka Univ., 2. Hamamatsu Photonics K.K.)

[1P-101]Prediction of Nitrogen Fixation Activity in Soybean Nodules Using Raman Spectroscopy

*Shunnosuke Suwa1,2, Koki Kashiwagi1, Masahiro Ando2,3, Takuma Kyotani1, Kento Hasegawa1,2, Habibi Safiullahr4, Naoko Otsu4, Haruko Takeyama1,2,3,5 (1. Graduate School of Advanced Science and Engineering, Waseda University, 2. Waseda University Computational Bio Big-Data Open Innovation Laboratory, 3. Research organization for Nano and Life Innovation, 4. Graduate School of Agriculture, Tokyo University of Agriculture and Technology, 5. Institute for Advanced Research of Biosystem Dynamics, Waseda Research Institute for Science and Engineering, Waseda University)

[1P-102]Development of a stress detection biosensor using pseudoknot aptamer.

*Aoi Morita1, Rina Uchida4, Rino Uejima4, Yasushi Mitsunaga2, Shinsuke Torisawa2, Yasuhisa Kobayasi2, Tsunemasa Saiki3, Eiichiro Takamura4, Hiroaki Sakamoto4 (1. Faculty of Engineering, University of Fukui, 2. Kindai University, 3. Hyogo Prefectural Institute of Technology, 4. Graduate School of Engineering, University of Fukui)

[1P-103]Smart diagnosis and monitoring of early-stage oral cancer based on image analysis

*Airi Yanagihara1, Yui Watanabe4, Maho Koda4, Momoka Nakai4, Han-Sheng Chuang2, Tatsuhito Hasegawa4, Chisato Sakamoto3, Eiichiro Takamura4, Hiroaki Sakamoto4 (1. Faculty of Engineering ,University of Fukui , 2. National Cheng Kung University, 3. National Institute of Technology ,Fukui College, 4. Graduate School of Engineering ,University of Fukui)

[1P-104]Multiplex biomolecular analysis based on the fluorescence imaging of DNA aptamer-labeled beads

*Reoto Mio1, Tatsuya Nishihara1, Kazuhito Tanabe1 (1. Graduate School of Science and Engineering, Aoyama Gakuin University)

[1P-105]Porous Membrane Electrode Device for Quantitative Evaluation of Alkaline Phosphatase Activity in a Human Intestinal Model

*Wakana Tani1, Yoshinobu Utagawa1, Hiroya Abe1,2, Kosuke Ino1, Hitoshi Shiku1 (1. Graduate School of Engineering, Tohoku University, 2. Frontier Research Institute for Interdisciplinary Sciences, Tohoku University)

[1P-106]EIS Measurement of Insulin Using a Cysteine-Modified Artificial Insulin Receptor

*Kazuma Nohara1, Hiroya Sato2, Eiji Arita2, Yoshiaki Yaguchi2, Takeshi Ikeda1, Takenori Ishida1, Ryuichi Hirota1, Akio Kuroda1, Hisakage Funabashi1 (1. Hiroshima University, 2. Terumo Corporation)

[1P-107]Development of a fluorescent substrate which deposits on cells in response to human orthogonal xylosidase.

*Akihiro Kuroda1, Akihiro Koga1, Miyazaki Yuji1, Ryosuke Kaneko2, Teruki Nii2, Akihiro Kishimura2,3, Takeshi Mori2, Yoshiki Katayama2,3 (1. Graduate School of Systems Life Sciences, Kyushu University, 2. Graduate School of Engineering, Kyusyu University, 3. Center for Molecular Systems, Kyushu University)

[1P-108]Ultra-sensitive detection of antigen proteins in microdroplet using "human orthologonal enzymes”

*Ryosei Kaguma1, Ryosuke Kaneko2, Akihiro Koga1, Yuu Fujimura3, Teruki Nii2, Akihiro Kishiura2, Takeshi Mori2, Yoshiki Katayama2 (1. Graduate School of Systems Life Sciences, Kyushu University, 2. Graduate School of Engineering, Kyusyu University, 3. On-chip Biotechnologies Co., Ltd.)

[1P-109]Direct detection of target nucleic acids on a solid surface by spraying DNA-nano-tweezers biosensing molecule.

*Reiji Shigematsu1, Hiroya Hatano1, Takenori Ishida1, Takeshi Ikeda1, Ryuichi Hirota1, Akio Kuroda1, Hisakage Funabashi1 (1. Hiroshima Graduate School of Integrated Sciences for Life)
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