Presentation Information
[1P-061]Development of 2′-Formamidonucleoside Analogues for Suppressing Seed-Based Off-Target Effects of siRNAs
*Ting Shi1, Kohei Nomura1, Seongjin An2, Yoshiaki Kobayashi3, Jiro Kondo4, Hirotaka Murase1, Kosuke Nakamoto1, Fumitaka Hashiya1, Yasuaki Kimura1, Naoko Abe1, Kumiko Ui-Tei2,3, Hiroshi Abe1,5,6,7 (1. Department of Chemistry, Graduate School of Science, Nagoya University, 2. Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, 3. Department of Biological Sciences, Graduate School of Science, The University of Tokyo, 4. Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 5. Research Center for Materials Science, Nagoya University, 6. CREST, Japan Science and Technology Agency (JST), 7. nstitute for Glyco-core Research (iGCORE), Nagoya University)
Keywords:
small interfering RNA,nucleic acid therapeutics,off-target,nucleic acid analogues,seed region