[H931-4pm] 17. Biofunctional Chemistry, Biotechnology

3:10 PM - 3:30 PM JST(6:10 AM - 6:30 AM UTC)Japanese

[H931-4pm-07] The Impact of Linker Structure and the Number of Fluorine-containing Functional Groups of Nucleic Acids on Cellular Uptake and siRNA Knockdown Efficacy

○Masako Takatsu¹, Kunihiko Morihiro¹, Yu Ota^1,2, Kosuke Aikawa¹, Takashi Okazoe^1,2, Akimitsu Okamoto¹ (1. The Univ. of Tokyo, 2. AGC Inc.)

Keywords:

Nucleic acid therapeutics,Conjugated-DNA/RNA,Drug delivery,Fluorine,Cellular uptake