The Annual Meeting of the Japanese Biochemical Society

[2PL1]Tofacitinib (CP-690,550): A First-In-Class Janus Kinase (JAK) Inhibitor for the Treatment of Rheumatoid Arthritis

^○Flanagan Mark E.(Pfizer Worldwide Medicinal Chemistry)

[3PL1]Cell- and tissue interactions during animal development

^○Takahashi Yoshiko(Department of Zoology, Biological Science, Graduate School of Science, Kyoto University)

[4PL1]Control of immune responses by regulatory T cells

^○Sakaguchi Shimon(Laboratory of Experimental Immunology, WPI Immunology Frontier Research Center, Osaka University)

[Introduction]Introduction

[Opening_Remarks]Opening Remarks

^○David Stewart

[2S11p-1]Using the functional identity of human genomes

^○Ronald McKay(The Lieber Institute for Brain Development, Baltimore, MD.)

[2S11p-2]Reprogramming cell fate and function

^○Deng Hongkui(Stem cell research Center, Peking University)

[2S11p-4]Investigation of Psychiatric/Neurological disorders using iPS cell technologies and transgenic non-human primates.

^○Okano Hideyuki(Dep. of Physiol., Sch. of Med. ., Keio Univ)

[2S11p-5]22 years after: STAT Proteins as Mediators of Peri-Genetics integrating Signal Transduction, Chromosome Remodeling and Transcription

^○Xin-Yuan Fu(Cancer Science Institute and Dept of Biochemistry, National University of Singapore)

[1S02-1]Disease-specific iPSC for medical research in incurable diseases of children

^○Yamamoto Toshiyuki¹, Shimojima Keiko^1,2(1.TIIMS, Tkyo Women's Med Univ., 2.PRESTO, JST)

[1S02-2]Recapitulation of heart diseases using iPS cells

^○Yoshida Yoshinori(Center for iPS cell Research and Application, Kyoto University)

[1S02-3]iPSC technology for the Story of Neural Regeneration and Degeneration

^○Inoue Haruhisa^1,2(1.CiRA, Kyoto Univ., 2.JST CREST)

[1S02-4]Regeneration of T cells via iPSC technology

^○Kaneko Shin(Shin Kaneko Lab., Dept. Cell Growth and Differentiation, CiRA, Kyoto Univ.)

[1S02-5]Studying for the iPS cells derived from intractable diseases

^○Era Takumi, Soga Minami, Hamasaki Makoto(Dept. of Cell Modulation, IMEG, Kumamoto Univ.)

[1S03-0]【Beginning】

[1S03-1]Role of lipid mediators in skin inflammatory diseases

^○Kabashima Kenji(Department of Dermatology, Kyoto University, Japan)

[1S03-2]Phospholipase A2-driven lipid network in immunity

^○Taketomi Yoshitaka¹, Murakami Makoto^1,2(1.Lipid Metab. Proj., Tokyo Metr. Inst. Med. Sci., 2.CREST, JST)

[1S03-3]Constitutive lymphocyte trafficking into lymph nodes is regulated by the autotaxin/lysophosphatidic acid axis.

^○Miyasaka Masayuki¹, Umemoto Eiji², Takeda Akira², Hata Erina², Sasaki Naoko²(1.IPBS, IAI, Osaka University, 2.Immune Regulation, Osaka Univ. Grad. Sch. Med.)

[1S03-4]Immune responses against glycolipids through C-type lectin receptors

^○Yamasaki Sho(Div. of Mol. Immunol. Med. Inst. of Bioreg., Kyushu Univ.)

[1S03-5]Genetic and lipidomic approach for the anti-inflammatory properties of n-3 polyunsaturated fatty acid

^○Arita Makoto^1,2,3(1.Lab. for Metabolomics, IMS, RIKEN, 2.Grad. Sch. of Med. Life Sci., Yokohama City Univ., 3.PRESTO, JST)

[1S04-1]Tight junction protein claudin-1 and hepatitis C virus infection

^○Fukasawa Masayoshi(Dept. of Biochem. & Cell Biol., Natl. Inst. of Infect. Dis.)

[1S04-2]Lipid domain and viral infection

^○Kobayashi Toshihide(Lipid Biol Lab, RIKEN)

[1S04-3]Membrane microdomain ortho-signaling therapy

^○Inokuchi Jin-ichi(Div. of Glycopathol., Inst. of Mol. Biomembrane and Glycobiology, Tohoku Phar,. Univ.)

[1S04-4]Ongoing activation of sphingosine 1-phosphate receptors mediates maturation of exosomal multivesicular endosomes

kajimoto Taketoshi, Okada Taro, Miya Satoshi, Zhang Lifang,^○Nakamura Shun-ichi(Div. of Biochem. Kobe Univ. Grad. School of Med.)

[1S04-5]Regulation of cholesterol biosynthesis and trafficking through membrane contact site and acidic environment in Golgi apparatus

^○Maeda Yusuke^1,2, Kinoshita Taroh^1,2, Okuzaki Daisuke³(1.Dept. of Immunoreg., RIMD., Osaka Univ., 2.Immunoglyco., iFReC., Osaka Univ., 3.DDCID., RIMD., Osaka Univ.)

[1S04-6]Role of mitochondrial ubiquitin ligase MITOL in MAM regulation and diseases

^○Yanagi Shigeru, Tokuyama Takeshi, Takeda Keisuke, Inatome Ryoko, Nagashima Shun(Lab. of Mol. Biochem., Sch. of Life Sci., Tokyo Univ. of Pharm. and Life Sci.)

[1S04-7]【総合討論】

[1S05-1]C-Mannosylation of Tryptophan Residues in the Endoplasmic Reticulum

^○Bakker Hans, Shcherbakova Aleksandra, Buettner Falk FR, Tiemann Birgit(Dept. of Cellular Chemistry, Hannover Medical School, Germany)

[1S05-2]Degradation of aberrant dolichol-linked oligosaccharides by a putative pyrophosphatase

^○Harada Yoichiro, Suzuki Tadashi(Glycometabolome Team, Systems Glycobiology Research Group, RIKEN-Max Planck Joint Research Center, Global Research Cluster, RIKEN)

[1S05-3]Crystal structures of oligosaccharyltransferase provide insights into the sequon recognition and activation of N-linked protein glycosylation

^○Kohda Daisuke(Div. of Struct. Biol., Med. Inst. of Bioreg., Kyushu Univ.)

[1S05-4]Structural insights into glycoprotein processing mechanisms in ER quality control system

^○Satoh Tadashi^1,2, Kato Koichi^1,3(1.Grad. Sch. Pharm. Sci., Nagoya City Univ., 2.JST, PRESTO, 3.Okazaki Inst. Integ. Biosci.)

[1S05-5]O-GlcNAcylation in the endoplasmic reticulum

^○Okajima Tetsuya, Ogawa Mitsutaka, Furukawa koichi(Nagoya Univ. Sch. of Med.)

[1S05-6]Unexpectedly specific role of Meigo, an endoplasmic reticulum protein in neural development

^○Chihara Takahiro^1,2, Sekine Sayaka¹, Moriya Hiroyuki¹, Miura Masayuki^1,2(1.Dept of Genetics, Grad Sch of Pharm Sci, The Univ. of Tokyo, Tokyo, Japan, 2.CREST, JST)

[1S05-7]【Discussion/Closing remarks】

[1S06-1]Molecular complex coordinating peroxisome morphogenesis in mammalian cells

^○Fujiki Yukio, Itoyama Akinori, Abe Yuichi, Honsho Masanori(Dept. of Biology, Faculty of Sciences, Kyushu University Graduate School)

[1S06-2]Phospholipid trafficking between mitochondria and the endoplasmic reticulum

^○Tamura Yasushi¹, Endo Toshiya²(1.RCMS, Nagoya Univ., 2.Fac. of Life Sci.)

[1S06-3]Shuttling of Rab7 regulates Parkin-mediated mitophagy

^○Koji Yamano^{1, 2} , Richard J. Youle¹(1.Biochemistry Section, Surgical Neurology Branch, NINDS, National Institutes of Health, USA, 2.Present address: Protein Metabolism Project, Tokyo Metropolitan Institute of Medical Science)

[1S06-4]Signalling pathways regulating mitochondrial protein import

^○Meisinger Chris(Inst. of Biochemistry, University of Freiburg, Germany)

[1S06-5]Functional analysis of stress signaling in mitochondria

^○Ichijo Hidenori, Sekine Shiori(Lab. Cell Signal., Grad. Sch. Pharm. Sci., The Univ. of Tokyo)

[1S06-6]Surveillance of Mitochondrial Homeostasis by the PINK1-Parkin System

^○Tanaka Keiji(Tokyo Metro Ins Med Sci)

[1S07-0]【Beginning】

[1S07-1]Evaluation of drug-induced QT-prolongation in human iPS-derived cardiomyocytes

^○Kurokawa Junko¹, Ashihara Takashi³, Kanda Yasunari²(1.Dept Bio-info Pharmacol, MRI, Tokyo Med Dent Univ, 2.Div Pharmacol, NIHS, 3.Dept Cardiovasc Med, Shiga Univ Med Sci)

[1S07-2]Role of substrate rigidity on function in human iPS cell-derived cardiomyocytes

^○Kanda Yasunari¹, Sekino Yuko¹, Furukawa Tetsushi², Kurokawa Junko²(1.Div Pharmacol, NIHS, 2.Dept Bio-informational Pharmacol, MRI, Tokyo Med Dent Univ)

[1S07-3]cAMP signal as target of anti-arrhythmic therapy

^○Ishikawa Yoshihiro(Cardiovascular Research Institute, Ykohama City University School of Medicine)

[1S07-4]The role of activator of G-protein signaling 8 (AGS8), a receptor-independent regulatory protein for heterotrimeric G-proteins, in the hypoxia-induced apoptosis of cardiomyocytes

^○Sato Motohiko, Hayashi Hisaki, Mamun Abdullah Al, Suzuki Hiroko, Sakima Miho, Iwase Satoshi, Inukai Yoko, Nishimura Naoki, Sato Maki(Dept. of Physiology, Aichi Med. Univ.)

[1S07-5]Histone deacetylase 6 in cardiac disease

^○Sanbe Atsushi(Dept. Pharmacothera., Schl Pharm., Iwate Medical Univ.)

[1S07-6]Prokineticin receptor in heart and kidney deveploment and diseases

^○Nebigil Canan G.(University of Strasbourg, CNRS, UMR7242)

[1S07-7]The physiological and pathological roles of cardiac fibroblasts

^○Kurose Hitoshi, Nakaya Michio(Dep. Pharmacol. Toxicol., Grad. of Pharm. Sic, Kyushu University)

[1S11-1]Methods for the analysis of biological functions using split luciferase complementation

^○Ozawa Takeaki(Dep. of Chem., Sch. of Sci., The Univ. of Tokyo)

[1S11-2]Visualization of virus-host interaction dynamics

^○Nanbo Asuka, Ohba Yusuke(Dept. Cell Physiol., Grad. Sch. Med., Hokkaido Univ.)