The Annual Meeting of the Japanese Biochemical Society

[1PL01]Insights into the Future from Analysis of the Past Genetic Research and its Impact on the future of Personalized Medicine

^○James Douglas Engel(G. Carl Huber Professor, Department of Cell and Developmental Biology, University of Michigan Medical School)

[3PL01]Targeting the Nrf2 Signaling Pathway for Cancer Prevention

^○Thomas W Kensler(University of Pittsburgh and Johns Hopkins University)

[2M01]Recent progress in phospholipid research

^○Takao Shimizu(National Center for Global Health and Medicine/The University of Tokyo)

[2M02]PGRMC1: A novel CO-responsive regulator of cancer

^○Makoto Suematsu(Department of Biochemistry, Keio University School of Medicine)

[2M03]Novel functions of nuclear transport factors

^○Yoshihiro Yoneda(National Institutes of Biomedical Innovation, Health and Nutrition)

[3M01]My Proteasome Study

^○Keiji Tanaka(Tokyo Metropolitan Institute of Medical Science)

[3M02]Discovery of drug target molecules based on natural products chemical biology

^○Minoru Yoshida(RIKEN)

[3M03]Lesson from my research for last 60 years

^○Susumu Nishimura(Laboratory Animal Resource Center, Univ. of Tsukuba)

[1AL01]Wnt シグナルによる細胞機能制御とその異常による病態

^○Akira Kikuchi(Department of Molecular Biology and Biochemistry, Graduate School of Medicine, Osaka University)

[2AL-1]中心小体複製の分子機構の研究

^○Daiju Kitagawa(国立遺伝学研究所分子遺伝研究系)

[2AL-2]両方向性の浸透圧ストレス応答を統御する ASK3 の研究

^○Isao Naguro(東京大学大学院薬学系研究科)

[2AL-3]生体漠変形タンパク質による細胞膜の張力を介したアクチン重合制御機構

^○Kazuya Tsujita(神戸大学バイオシグナル総合研究センター)

[2AL-4]ホスホリバーゼCδの生理機能解析

^○Yoshikazu Nakamura(東京薬科大学生命科学部)

[2AL-5]エンハンサーの破綻が引き起こす血液疾患の解析

^○Mikiko Suzuki(東北大学大学院医学系研究科)

[1S01-1]TRP channels in oxygen sensing and adaptation

^○Yasuo Mori(Kyoto Univ. Grad. Sch. Engineering)

[1S01-2]Differential function of catalase, glutathione peroxidase, and peroxiredoxins in mouse red blood cells

^○Sue Goo Rhee(Yonsei Biomedical Research Institute, Yonsei University College of Medicine)

[1S01-3]Elucidation of Nrf2-centered transcriptional network toward the disease prevention and therapy

^○Ken Itoh(Dept. of Stress Sci., Hirosaki Univ. Grad. Sch. of Med.)

[1S01-4]Cysteinyl-tRNA synthetase is a major source of reactive persulfide and controls mitochondrial biology

^○Takaaki Akaike(Dept. of Environ. Health Sci. Mol. Toxicol., Tohoku Univ. Grad. Sch. Med.)

[1S01-5]Regulation of cardiac oxygen remodeling via electrophilic modification of Drp1

^○Motohiro Nishida(Div. of Cardiocirc. Signal., Okazaki Inst. for Integr. Biosci. (Natl. Inst. for Physiol. Sci.), Natl. Inst. of Nat. Sci.)

[1S01-6]The phase zero reaction: Capture of electrophiles by reactive sulfur species

^○Yoshito Kumagai(Environmental Biology Laboratory, Faculty of Medicine, University of Tsukuba)

[1S02-1]Basics and recent topics of genome editing technology

^○Takashi Yamamoto(Department of Mathematical and Life Sciences, Hiroshima University, Higashi-Hiroshima, Japan)

[1S02-2]Crystal structures of CRISPR-Cas9 and CRISPR-Cpf1

^○Hiroshi Nishimasu^1,2, Takashi Yamano¹, Hisato Hirano¹, Ryuichiro Ishitani¹, Osamu Nureki¹(1.Dept. of Biol. Sci., Grad. Sch. of Sci., Univ. of Tokyo, 2.JST, PRESTO)

[1S02-3]Optical control of the genome

^○Moritoshi Sato(Graduate School of Arts and Science, The University of Tokyo)

[1S02-4]CRISPR/Cas9 mediated genome editing in ES cells and its application for study of reproduction

^○Masahito Ikawa(Res. Inst. Mictobial. Dis., Osaka Univ.)

[1S02-5]Case Report about production of genome edited mouse by CRISPR/Cas9 system.

^○Seiya Mizuno^1,2, Satoru Takahashi^1,3, Fumihiro Sugiyama^1,2(1.Laboratory Animal Resource Center, University of Tsukuba, 2.Department of Laboratory Animal Science, Faculty of Medicine, University of Tsukuba, 3.Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba)

[1S02-6]Efficient Human Genome Editing by CRISPR Tool Box

^○Akitsu Hotta^1,2(1.Dep. of Life Sci. Frontiers, CiRA, Kyoto Univ., 2.iCeMS, Kyoto Univ.)

[1S02-7]Functional analysis of human colon carcinogenesis and cancer stem cells using genome editing

^○Toshiro Sato, Yuki Ohta, Mami Matano, Masayuki Fujii, Mariko Shimokawa(Dep. Gastro., Keio Univ. Sch. of Med.)

[1S03-1]Development of New Chemical Probes to Analyze the Protein - Bioactive Ligand Interactions

^○Masaki Kita^1,2(1.Dept. of Chem., Grad. Sch. of Pure & Appl. Sci., Univ. of Tsukuba, 2.PRESTO, JST)

[1S03-2]Chemical biology of plant bioactive compounds

^○Minoru Ueda(Dep. Chemistry, Faculty of Science, Tohoku Univ.)

[1S03-3]Usefulness of silkworm infection model for development of novel antibiotics

^○Kazuhisa Sekimizu(Teikyo Univ. Ins. of Med. Mycol.)

[1S03-4]High throughput screening of the drug seeds by the chemical array method

^○Hiroyuki Osada(Chemical Biology, RIKEN CSRS)

[1S03-5]Drug development for exon skipping and exon inclusion therapies to cure genetic diseases.

^○Masatoshi Hagiwara¹, Kei Iida²(1.Departmet of Anatomy and Developmental Biology Graduate School of Medicine Kyoto University, 2.Medical Research Support Center Graduate School of Medicine Kyoto University)

[はじめに]Introduction

[1S04-1]Characterizing GPCR ligands using TGF-alpha shedding assay and G protein-deficient cells and their application to drug development in academia

^○Asuka Inoue^1,2, Junken Aoki^1,3(1.Lab. of Mol. Cell. Biochem., Grad. Sch. of Pharm. Sci., Tohoku Univ., 2.PRESTO, JST, 3.AMED-CREST, AMED)

[1S04-2]Characterization of disease-related enzymatic functions with use of small molecular fluorescent substrate probes

^○Toru Komatsu^1,4, Kouichi Yanagi¹, Kenjiro Hanaoka¹, Tetsuo Nagano³, Yasuteru Urano^2,5(1.Grad. Sch. Pharm. Sci., The Univ. Tokyo, 2.Grad. Sch. Med., The Univ. Tokyo, 3.DDI, The Univ. Tokyo, 4.JST PRESTO, 5.AMED-CREST)

[1S04-3]Application of cell-free technology for drug discovery

^○Hiroyuki Takeda, Hirotaka Takahashi, Keiichiro Nemoto, Atsushi Uematsu, Shunsuke Nomura, Tatsuya Sawasaki(PROS, Ehime Univ.)

[1S04-4]A small molecule inhibitor of SOD1-Derlin-1 interaction ameliorates ALS pathology

^○Naomi Tsuburaya, Kengo Homma, Hidenori Ichijo(Cell Signaling, Grad. Sch. of Pharmaceut. Sci., Univ. of Tokyo)

[1S04-5]Drug discovery of next generation erythropoiesis-stimulating agent

^○Hiroshi Kaneko¹, Hideyuki Saya², Masayuki Yamamoto³, Ritsuko Shimizu¹(1.Dpt. of Mol. Hematol., Grad. sch. of Med., Tohoku Univ., 2.Div. of Gene Regulation, Inst. for Advanced Med. Res., Keio University Sch. of Med., 3.Dept. of Med. Biochem., Grad. sch. of Med., Tohoku Univ.)

[1S04-6]Development of novel anti-cancer and anti-inflammatory drugs that regulate chemokine signaling

^○Yuya Terashima(Dept. Mole. Prev. Med., Fac. Med., Univ. of Tokyo)

[1S04-7]Exploration for anti-poliovirus compounds that target host factors and viral replication step

^○Minetaro Arita(Department of Virology II, National Institute of Infectious Diseases)

[まとめ]Conclusion

[1S05-1]Reconstruction of trans-omic network of insulin action from phosphoproteome and metabolome data

^○Shinya Kuroda, Katsuyuki Yugi(Dept. Biological Sciences, Univ. Tokyo.)

[1S05-2]Mutli-omics Analysis of Tumor Microenvironment and Cancer Metabolism

^○Tsuyoshi Osawa¹, Teppei Shimamura², Satoru Miyano³, Tomoyoshi Soga⁴, Tatsuhiko Kodama¹(1.Systems Biol. Med., RCAST, The Univ. of Tokyo, 2.Systems Biol. Med., Nagoya Univ., 3.Human Genome Center, IMS, Univ. of Tokyo, 4.Institute. Adv. Biosci., Keio Univ.)

[1S05-3]Multi-omics Analysis of Colorectal Cancer Metabolism

^○Tomoyoshi Soga^1,2(1.Inst. Adv. Biosci., Keio Univ., 2.AMED-CREST)

[1S05-4]Development of personalized cancer immunotherapy by Trans-OMICS analysis

^○Koji Ueda(Cancer Proteomics Gr., Genome Ctr., JFCR)

[1S05-5]Japanese Multi Omics Reference Panel Ver.2

^○Seizo Koshiba¹, Daisuke Saigusa¹, Ikuko Motoike^1,2, Kaname Kojima¹, Matsuyuki Shirota^1,3, Tomo Saito¹, Fumiki Katsuoka¹, Yosuke Kawai¹, Yumi Yamaguchi¹, Osamu Tanabe¹, Masao Nagasaki¹, Jun Yasuda¹, Kengo Kinoshita^1,2, Masayuki Yamamoto^1,3(1.Tohoku Medical Megabank organization, Tohoku Univ., 2.Grad. Sch. of Info. Sci., 3.Grad. Sch. of Med.)

[はじめに]Introduction

[1S06-1]Immune regulation associated with dead cell clearance by CD169-positive macrophages

^○Masato Tanaka, Kenta Kikuchi, Kenichi Asano(Lab. of Immune Reg., Sch. of Life Sci., TUPLS)

[1S06-2]Phagocytosis of dying cells in neuronal regeneration in the adult brain

^○Kazunobu Sawamoto^1,2(1.Dept. of Develop. and Regen. Biol., Nagoya City Univ. Grad. Sch. of Med. Sci., 2.Div. of Neural Dev. and Regen., Inst. of Phys. Sci.)

[1S06-3]Protein Chemical Labeling Catalyzed by Iron Oxidation State of Heme

^○Shinichi Sato, Kosuke Nakamura, Hiroyuki Nakamura(Laboratory for Chemistry and Life Science, Tokyo Institute of Technology,)