[1T06] Biology of Diseases 01 | The 97th Annual Meeting of the Japanese Biochemical Society

Session Details

Talk

[1T06]Biology of Diseases 01

Wed. Nov 6, 2024 11:05 AM - 12:35 PM JST
Wed. Nov 6, 2024 2:05 AM - 3:35 AM UTC

Room6(G302)

Organizers: Maki Tsujita（Nagoya City University Graduate School of Medical Sciences）, Ken Saito（Dep. Clin. Eng. Med. Tech. Niigata Univ. Health and Welfare）

11:05 AM - 11:14 AM JST(2:05 AM - 2:14 AM UTC)

[1T06-01]Fatty Acid Desaturase 2 (FADS2) promotes tumorigenesis in cholangiocarcinoma

^○Haruna Fujimori¹, Hasegawa Kohsei¹, Kohta Nakatani², Masatomo Takahashi², Yoshihiro Izumi², Takeshi Bamba², Rie Shibuya-Takahashi¹, Mai Mochizuki¹, Kazunori Yamaguchi³, Jun Yasuda³, Naoki Asano¹, Keiichi Tamai¹ (1.Div. Cancer Stem Cell, Miyagi Cancer Ctr. Res. Inst., 2.Med. Inst. Bioreg., Kyushu Univ., 3.Div. Mol. & Cell. Oncol., Miyagi Cancer Ctr. Res. Inst.)

キーテクノロジー：リピドミクス、PDX

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11:14 AM - 11:23 AM JST(2:14 AM - 2:23 AM UTC)

[1T06-02]Phospholipase, PNPLA6 relates to the regulation of cell membrane lipid in malignant transformation

^○Rina Takamiya^1,2, Yuki Nagasaki², Hiromu Suzuki³, Makoto Murakami^2,4 (1.Dept. of Biochem., Sch.of Med., Hyogo Med. Univ., 2.CDBIM, Grad. Sch. of Med., The Univ. of Tokyo, 3.Dept. of Mol. Biol., Sch. of Med., Sapporo Med. Univ., 4.AMED-CREST)

キーテクノロジー：リピドミクス解析

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11:23 AM - 11:32 AM JST(2:23 AM - 2:32 AM UTC)

[1T06-03]Concurrent inhibition of GSK3 and MEK as a novel strategy to treat pancreatic cancer

^○Masahiro Sonoshita (Institute for Genetic Medicine, Hokkaido University)

キーテクノロジー：Whole-body phenotypic screen

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11:32 AM - 11:41 AM JST(2:32 AM - 2:41 AM UTC)

[1T06-04]Exploring of diagnostic markers for urothelial carcinoma

^○Tsutomu Fujimura, Sachiko Komatsu (Tohoku Medical and Pharmaceutical University)

キーテクノロジー：診断マーカー

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11:41 AM - 11:50 AM JST(2:41 AM - 2:50 AM UTC)

[1T06-05]Detection of Cancer-specific exosomes using the exosome-counting system ExoCounter

^○Yasuaki Kabe (Department of Biochemistry, Kochi Medical Schoool, Kochi University)

キーテクノロジー：エクソソーム絶対計測システム

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11:50 AM - 11:59 AM JST(2:50 AM - 2:59 AM UTC)

[1T06-06]E3 ubiquitin ligase MIB1 regulates PLK1, induces chromosomal instability and is involved in malignant transformation in glioma

^○Keiji Koshiba¹, Jingyu Lu², Yuki Ohta², Takamasa Mizoguchi², Motoyuki Itoh² (1.Faculty of Pharmaceutical Science, Chiba University, 2.Graduate School of Pharmaceutical Sciences, Chiba University)

キーテクノロジー：ゼノグラフト

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11:59 AM - 12:08 PM JST(2:59 AM - 3:08 AM UTC)

[1T06-07]Establishment of a glioblastoma cell line accumulating the rare phospholipid PI(5)P

^○Miko Oikawa¹, Kaoru Tamura², Haruka Abeki¹, Shin Morioka¹, Toshiyoshi Yamamoto¹, Jyunko Sasaki¹, Takehiko Sasaki¹ (1.Department of Biochemical Pathophysiology, Medical Research Institute, Tokyo Medical and Dental University, 2.Department of Functional Neurosurgery, Tokyo Medical and Dental University)

キーテクノロジー：LC-MS/MS

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12:08 PM - 12:17 PM JST(3:08 AM - 3:17 AM UTC)

[1T06-08]Elucidation of the mechanism by which the ubiquitin ligase MKRN1 suppresses ferroptosis

^○Yutaro Yamada, Yusuke Hirata, Takuya Noguchi, Atsushi Matsuzawa (Lab. of Health Chem., Grad. Sch. of Pharmaceut. Sci., Tohoku Univ.)

キーテクノロジー：次世代シーケンス

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12:17 PM - 12:26 PM JST(3:17 AM - 3:26 AM UTC)

[1T06-09]Anti-cancer effect of the novel geldanamycin derivatives targeting NRF2-activated esophageal squamous cell carcinoma

^○Hiroyuki Oshikiri, Keiko Taguchi, Liam Baird, Masayuki Yamamoto (Department of Biochemistry and Molecular Biology, Tohoku Medical Megabank Organization, Tohoku University)

キーテクノロジー：キノン代謝による薬剤の活性化

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12:26 PM - 12:35 PM JST(3:26 AM - 3:35 AM UTC)

[1T06-10]Activation of the WDR1 gene by deregulated E2F1 forms positive feedback loop in tumor suppressive E2F1 activity

^○Mashiro Shirasawa, Kiyoshi Ohtani (Dept. of Biomed. Chem. Grad. Sch. of Sci. and Tech. Kwansei Gakuin Univ.)

キーテクノロジー：遺伝子発現制御

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