[P013] Structural biology, prediction of function and drug design

11:45 AM - 12:30 PM JST(2:45 AM - 3:30 AM UTC)

[1P-069] Modulating RAF Conformational Dynamics: Inactive States as Novel Drug Targets

^○Wakako F. Sakisaka¹, Yohei M. Koyama², Matsumoto Shigeyuki ³, Honda Kou ⁴, Kawamura Takashi⁵, Okamura Megumi¹, Yoshikawa Yoko¹, Okimoto Noriaki ², Kumasaka Takashi⁵, Tamura Atsuo ⁴, Taiji Makoto², Shima Fumi ¹ (1.Grad. Sch. Sci. Tec. Innov., Kobe Univ., 2.RIKEN, 3.Grad. Sch. Med., Kyoto Univ , 4.Grad. Sch. Sci., Kobe Univ. , 5.Diffr. Scatt. Div., JASRI)

キーテクノロジー：MDシミュレーション

Keywords:

RASシグナル阻害剤,RAS-RAF結合阻害,アロステリック構造変化,構造ダイナミクス,分子標的がん治療

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