The Annual Meeting of the Japanese Biochemical Society

[1S02m-01]Post-transcriptional dysregulation shapes the aging proteome: mechanisms and consequences

^○Masaki Takasugi, Naoko Ohtani(Department of Pathophysiology, Osaka Metropolitan University Graduate School of Medicine)

[1S02m-02]Dysfunction of dopamine in the entorhinal cortex induces associative memory impairment in Alzheimer's disease mouse models

^○Kei M. Igarashi(Department of Anatomy & Neurobiology, School of Medicine, University of California, Irvine)

[1S02m-03]Elucidation of the heterogeneity system of mesenchymal stromal cells that support skeletal muscle homeostasis

^○Akiyoshi Uezumi(Division of Cell Heterogeneity, Medical Institute of Bioregulation, Kyushu University)

[1S02m-04]Tracing Inflammation and Molecular Changes in the Aging Kidney

^○Motoko Yanagita(Department of Nephrology, Graduate School of Medicine, Kyoto University)

[1S02m-05]The roles and mechanisms of cellular senescence

^○Eiji Hara(Research Institute for Microbial Diseases, The University of Osaka)

[1S03m-01]The novel function of lipid flux on RORγt-mediated Th17 cell pathogenicity

^○Yusuke Endo(KAZUSA DNA RESEARCH INSTITUTE)

[1S03m-02]On the biochemical dialog between immune cells mediating anti-cancer responses

^○Sidonia Fagarasan^1,2(1.Laboratory for Mucosal Immunity, RIKEN Center for Integrative Medical Sciences, 2.Division of Integrated High-Order Regulatory Systems, Center for Cancer Immunotherapy and Immunobiology, Kyoto University)

[1S03m-03]Immune Evasion Through Mitochondrial Transfer: A "Mitochondrial Hijack" Mechanism

^○Yosuke Togashi^1,2(1.Department of Tumor Microenvironment, Faculty of Medicine, Dentistry and Pharmaceutical Sciences (Medicine), Okayama University, 2.OKAYAMA UNIVERSITY HOSPITAL, Department of Allergy and Respiratory Medicine)

[1S03m-04]Metabolic Exhaustion in Tumor-Infiltrating T Cells: Role of Active Aldehydes in Glycolysis and FAO Balance

^○Kenji Chamoto(Department of Immuno-Oncology PDT, Kyoto University Graduate School of Medicine)

[1S03m-05]Systemic metabolism regulates T cell ferroptosis and functionality

^○Di Yu^1,2(1.The University of Queensland Frazer Institute, The University of Queensland and Translational Research Institute, 2.Ian Frazer Centre for Children's Immunotherapy Research, Child Health Research Centre, The University of Queensland)

[1S04m-00]Introduction

^○Hiromi Hirata(Aoyama Gakuin University)

[1S04m-01]Evolution of egg envelope formation in teleosts based on potential polymerization mechanisms.

^○Kaori Sano¹, Mai Yabe², Kana Watanabe², Shinji Kanda³(1.Faculty of Science, Josai University, 2.Graduate School of Pharmaceutical Sciences, Josai University, 3.Atmosphere and Ocean Research Institute, The University of Tokyo)

[1S04m-02]Modular structure of gametogenesis driving the diversification of reproductive modes

^○Mariko Kikuchi¹, Yu Ikeda², Shuji Shigenobu³, Minoru Tanaka¹(1.Department of Biological Science, Graduate School of Science, Nagoya University, 2.Department of Biological Science, School of Science, Nagoya University, 3.Trans-Omics Facility, National Institute of Basic Biology)

[1S04m-03]Transplantation of germline stem cells from semelparous salmon into iteroparous rainbow trout alters their function to that of the recipient

^○Goro Yoshizaki(Tokyo University of Marine Science and Technology)

[1S04m-04]Ultra-short-lived fish reveals unexpected mechanisms of healthy longevity

^○Tohru Ishitani(RIMD, The University of Osaka)

[1S04m-05]Color information generated by a single type of opsin in the zebrafish pineal organ

^○Seiji Wada(Aoyama Gakuin University)

[1S04m-06]Uncovering a novel photobiological mechanism through pituitary research in medaka

^○Ayaka Fukuda¹, Keita Sato², Shinji Kanda³(1.National Institute for Basic Biology, National Institutes of Natural Sciences, 2.Faculty of Medicine, Dentistry, and Pharmaceutical Science, Okayama University, 3.Atmosphere and Ocean Research Institute, The University of Tokyo)

[1S04m-07]Closing Remarks

[1S05m-01]Toward High-Sensitivity, Whole-Transcript Spatial Transcriptomics

^○Akiko Oguchi^1,2, Raku Son^1,2, Yasuhiro Murakawa^1,2(1.Laboratory for Gene Structure and Regulation, RIKEN Center for Integrative Medical Sciences, 2.Institute for the Advanced Study of Human Biology (WPI-ASHBi), Kyoto University)

[1S05m-02]Precision Cardiovascular Medicine with Single-cell Analysis

^○Seitaro Nomura(The University of Tokyo)

[1S05m-03]Sequence grammar and dynamics of subcellular translation revealed by APEX-Ribo-Seq

^○Shintaro Iwasaki^1,2(1.Pioneering Research Institute, RIKEN, 2.Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo)

[1S05m-04]Proteomic characterization of the functional impact of co-/post-translational modifications

^○Koshi Imami(RIKEN Center for Integrative Medical Sciences)

[1S05m-05]Biophysical Proteomics

^○Mikhail Savitski(EMBL)

[1S06m-01]Molecular mechanism of bulk phospholipid transfer for autophagosome formation

^○Nobuo N. Noda^1,2(1.Institute for Genetic Medicine, Hokkaido University, 2.Institute of Microbial Chemistry)

[1S06m-02]How the lipid transfer protein Atg2 associates with the ER during autophagosome biogenesis

^○Hitoshi Nakatogawa(Cell Biology Center, Institute of Integrated Research, Institute of Science Tokyo)

[1S06m-03]A phosphorylation-driven functional switch in p62 bodies coordinates autophagic clearance of ubiquitinated proteins

^○Masaaki Komatsu(Juntendo University Graduate School of Medicine)

[1S06m-04]Restoration of autophagy defects reverses neuronal dysfunction

^○Noboru Mizushima, Tomoya Eguchi(The University of Tokyo)

[1S06m-05]Autophagy networks in the regulation of ER contact sites

^○Ivan Dikic^1,2(1.Institute of Biochemistry II, Goethe University, 2.Max Planck Institute for Biophysics)

[1S07m-00]Overview talk

^○Motohiko Kadoki(Harvard Medical School / Massachusetts General Hospital / Broad Institute of MIT and Harvard)

[1S07m-01]Hints for Revival: Reflections on Thesis Defense, Choosing a Postdoctoral Lab, the Path to Research Independence, and Competitive Research Funding

^○Yoji Andrew Minamishima(Department of Biochemistry, Gunma University Graduate School of Medicine)

[1S07m-02]To further develop what I learned while studying abroad

^○Akinobu Matsumoto(Graduate School of Science, Nagoya University)

[1S07m-03]Difference of Research Culture between Japan and the US through the angle of Systems Immunology Research

^○Motohiko Kadoki^1,2,3, Daniel G. Graham^1,2,3, Ramnik J. Xavier^1,2,3(1.Harvard Medical School, 2.Massachusetts General Hospital, 3.Broad Institute of MIT and Harvard)

[1S07m-04]The pathophysiological roles of amino acid transporter SLC7A5 in breast cancer

^○Yasuhiro Saito(Institute for Advanced Biosciences, Keio University)

[1S07m-05]Immunogenetics to understand the etiology of autoimmunity

^○Kazuyoshi Ishigaki^1,2,3(1.Department of Microbiology and Immunology, Keio University School of Medicine, 2.Keio University Human Biology-Microbiome-Quantum Research Center (WPI-Bio2Q), 3.Laboratory for Human Immunogenetics, RIKEN Center for Integrative Medical Sciences)

[1S07m-06]Discussion

[1S08m-01]PROTACs and molecular glue protein degraders: Molecular mechanism and drug design

^○Alessio Ciulli(University of Dundee)

[1S08m-02]Non-conventional PROTACs - Turning stress-response pathways into Trash-Anything machines

^○Tim Clausen(Research Institute of Molecular Pathology)

[1S08m-03]Development of IAP-based PROTACs, SNIPERs

^○Mikihiko Naito(The University of Tokyo)

[1S08m-04]Targeted protein degradation in mitochondria

^○Minoru Ishikawa(Graduate School of Life Scineces)

[1S08m-05]Development and application of protein degrader-dependent interaction analysis method

^○Satoshi Yamanaka^1,2, Yuta Yanagihara³, Kohei Nishino⁴, Yuuki Imai³, Hidetaka Kosako⁴, Tatsuya Sawasaki²(1.Division of Proteo-Interactome, Proteo-Science Center, Ehime University, 2.Division of Cell-Free Sciences, Proteo-Science Center, Ehime University, 3.Division of Integrative Pathophysiology, Proteo-Science Center, Ehime University, 4.Division of Cell Signaling, Fujii Memorial Institute of Advanced Medical Sciences, Tokushima University)

[1S09m-00]Introduction

^○Takafumi Suzuki(Tohoku University)

[1S09m-01]Molecular Mechanisms and Physiological Roles of the KEAP1-NRF2 Regulatory System

^○Takafumi Suzuki, Masayuki Yamamoto(Tohoku University)

[1S09m-02]Discovery of CH7450924, an NRF2 Activator Targeting KEAP1-NRF2 Protein-Protein Interaction (PPI), and Its Efficacy in Preclinical Multiple Organ Dysfunction Syndrome Models

^○Yukari Yasui¹, Masaki Hoshino², Shun Mistumata¹, Atsushi Kimbara¹, Takeo Harada¹, Naoshi Horiba¹(1.Research Division, Chugai Pharmaceutical Co., Ltd., 2.Chugai Research Institute for Medical Science, Inc.)

[1S09m-03]Yin-Yang regulatory dynamic of NRF1 through N-glycosylation

^○Yukiko Yoshida(Tokyo Metropolitan Institute of Medical Science)

[1S09m-04]Nrf3 drives cancer immune evasion via MHC-I degradation

^○Tsuyoshi Waku(Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University)

[1S09m-05]Molecular Basis of Transcriptional Regulation by Dimers Involving Small Maf Proteins

^○Fumiki Katsuoka(Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku Univ.)

[1S09m-06]Discussion

^○Fumiki Katsuoka(Advanced Research Center for Innovations in Next-Generation Medicine, Tohoku Univ.)

[1S10m-01]Analysis of the mechanism of organelle sharing between melanocytes and keratinocytes

^○Mitsunori Fukuda(Lab. of Membr. Trafficking Mech., Grad. Sch. of Life Sci., Tohoku Univ.)

[1S10m-02]Efficiency of protein transfer through the protrusion-derived extracellular vesicles

^○Shiro Suetsugu(Nara Institute of Science and Technology)

[1S10m-03]Intracellular remodeling mechanisms and their physiological functions during oocyte-to-embryo transition

^○Ken Sato¹, Ichiro Kawasaki¹, Kenta Sugiura¹, Shunichi Suto¹, Ikuko Maejima¹, Taeko Sasaki², Hidetaka Kosako³, Miyuki Sato²(1.Lab. of Mol. Traffic, IMCR, Gunma Univ., 2.Lab. of Mol. Membrane Biol., IMCR, Gunma Univ., 3.Div. of Cell Signaling, Insti. of Advanced Med. Sci., Tokushima Univ.)